Synthesis of 2‑Cyanomethyl Indane Derivatives via Pd-Catalyzed Alkene Difunctionalization Reactions of Alkyl Nitriles

Synthesis of 2‑Cyanomethyl Indane Derivatives via Pd-Catalyzed Alkene Difunctionalization Reactions of Alkyl Nitriles

The synthesis of indanes bearing substituted cyanomethyl groups at C2 is achieved through Pd-catalyzed coupling reactions between 2-allylphenyl triflate derivatives and alkyl nitriles. Related partially saturated analogues were generated from analogous transformations of alkenyl triflates. The use o...

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Veröffentlicht in:Organic letters 2023-04, Vol.25 (16), p.2767-2770
Hauptverfasser: Perez, Alma R., Bornowski, Evan C., Chen, Lei, Wolfe, John P.
Format: Artikel
Sprache:eng
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Zusammenfassung:The synthesis of indanes bearing substituted cyanomethyl groups at C2 is achieved through Pd-catalyzed coupling reactions between 2-allylphenyl triflate derivatives and alkyl nitriles. Related partially saturated analogues were generated from analogous transformations of alkenyl triflates. The use of a preformed BrettPhosPd­(allyl)­(Cl) complex as a precatalyst was essential for the success of these reactions.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.3c00571