Changes in Vaginal Bacteria and Inflammatory Mediators From Periconception Through the Early Postpartum Period in a Cohort of Kenyan Women Without HIV

Abstract Background Women's increased risk of HIV acquisition during pregnancy and postpartum may be mediated by changes in vaginal microbiota and/or cytokines. Methods A cohort of 80 Kenyan women who were HIV-1 seronegative contributed 409 vaginal samples at 6 pregnancy time points: periconcep...

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Veröffentlicht in:	The Journal of infectious diseases 2023-08, Vol.228 (4), p.487-499
Hauptverfasser:	Sabo, Michelle C, Lokken, Erica M, Srinivasan, Sujatha, Kinuthia, John, Richardson, Barbra A, Fiedler, Tina L, Munch, Matthew, Proll, Sean, Salano, Clayton, John-Stewart, Grace, Jaoko, Walter, Fredricks, David N, McClelland, R Scott
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Chemokines CXCL10 protein Cytokines Female HIV HIV Infections - complications Human immunodeficiency virus Humans Inflammation Inflammation Mediators Interleukin 6 Interleukin 8 Kenya - epidemiology Lactobacillus Ligands Major Microbiota Postpartum Postpartum Period Pregnancy Principal components analysis RNA, Ribosomal, 16S - genetics Vagina Vagina - microbiology Womens health
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