Study of neuropathological changes and dementia in 100 centenarians in The 90+ Study
INTRODUCTION The association between neuropathological changes and dementia among centenarians and nonagenarians remains unclear. METHODS We examined brain tissue from 100 centenarians and 297 nonagenarians from The 90+ Study, a community‐based longitudinal study of aging. We determined the prevalen...
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| Veröffentlicht in: | Alzheimer's & dementia 2023-08, Vol.19 (8), p.3417-3425 |
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| creator | Neuville, Raumin S. Biswas, Roshni Ho, Chu‐Ching Bukhari, Syed Sajjadi, Seyed Ahmad Paganini‐Hill, Annlia Montine, Thomas J. Corrada, María M. Kawas, Claudia H. |
| description | INTRODUCTION
The association between neuropathological changes and dementia among centenarians and nonagenarians remains unclear.
METHODS
We examined brain tissue from 100 centenarians and 297 nonagenarians from The 90+ Study, a community‐based longitudinal study of aging. We determined the prevalence of 10 neuropathological changes and compared their associations with dementia and cognitive performance between centenarians and nonagenarians.
RESULTS
A total of 59% of centenarians and 47% of nonagenarians had at least four neuropathological changes. In centenarians, neuropathological changes were associated with higher odds of dementia and, compared to nonagenarians, the odds were not attenuated. For each additional neuropathological change, the Mini‐Mental State Examination score was lower by 2 points for both groups.
DISCUSSION
Neuropathological changes continue to be strongly related to dementia in centenarians, highlighting the importance of slowing or preventing the development of multiple neuropathological changes in the aging brain to maintain cognitive health.
Highlights
Individual and multiple neuropathological changes are frequent in centenarians.
These neuropathological changes are strongly associated with dementia.
There is no attenuation of this association with age. |
| doi_str_mv | 10.1002/alz.12981 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10427735</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2786098470</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4161-bc3f49baa5159d3cd239dc4495c83d1fd0bd05d25b7e6f189ea50a091fa172d43</originalsourceid><addsrcrecordid>eNp1kc9PwjAUxxujEUQP_gOmR40B2m7d1pMhxF8JiQfx4qV5azuoGS2uTIN_vYMh0YOntq-ffN7L-yJ0TsmAEsKGUH4NKBMZPUBdyjnrc5aKw_09IR10EsIbITHJKD9GnShJBRecd9H0eVXrNfYFdqau_BJWc1_6mVVQYjUHNzMBg9NYm4VxKwvYOtz0xKp5GQeVBRc2tencYEGu8VZ3io4KKIM525099HJ3Ox0_9CdP94_j0aSvYprQfq6iIhY5AKdc6EhpFgmt4lhwlUWaFprkmnDNeJ6apKCZMMAJEEELoCnTcdRDN613WecLozczVVDKZWUXUK2lByv__jg7lzP_ISmJWZpGvDFc7gyVf69NWMmFDcqUJTjj6yBZmiVEZHFKGvSqRVXlQ6hMse9DidzEIJsY5DaGhr34Pdie_Nl7Awxb4NOWZv2_SY4mr63yG2kskhs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2786098470</pqid></control><display><type>article</type><title>Study of neuropathological changes and dementia in 100 centenarians in The 90+ Study</title><source>MEDLINE</source><source>Wiley Blackwell Journals</source><creator>Neuville, Raumin S. ; Biswas, Roshni ; Ho, Chu‐Ching ; Bukhari, Syed ; Sajjadi, Seyed Ahmad ; Paganini‐Hill, Annlia ; Montine, Thomas J. ; Corrada, María M. ; Kawas, Claudia H.</creator><creatorcontrib>Neuville, Raumin S. ; Biswas, Roshni ; Ho, Chu‐Ching ; Bukhari, Syed ; Sajjadi, Seyed Ahmad ; Paganini‐Hill, Annlia ; Montine, Thomas J. ; Corrada, María M. ; Kawas, Claudia H.</creatorcontrib><description>INTRODUCTION
The association between neuropathological changes and dementia among centenarians and nonagenarians remains unclear.
METHODS
We examined brain tissue from 100 centenarians and 297 nonagenarians from The 90+ Study, a community‐based longitudinal study of aging. We determined the prevalence of 10 neuropathological changes and compared their associations with dementia and cognitive performance between centenarians and nonagenarians.
RESULTS
A total of 59% of centenarians and 47% of nonagenarians had at least four neuropathological changes. In centenarians, neuropathological changes were associated with higher odds of dementia and, compared to nonagenarians, the odds were not attenuated. For each additional neuropathological change, the Mini‐Mental State Examination score was lower by 2 points for both groups.
DISCUSSION
Neuropathological changes continue to be strongly related to dementia in centenarians, highlighting the importance of slowing or preventing the development of multiple neuropathological changes in the aging brain to maintain cognitive health.
Highlights
Individual and multiple neuropathological changes are frequent in centenarians.
These neuropathological changes are strongly associated with dementia.
There is no attenuation of this association with age.</description><identifier>ISSN: 1552-5260</identifier><identifier>ISSN: 1552-5279</identifier><identifier>EISSN: 1552-5279</identifier><identifier>DOI: 10.1002/alz.12981</identifier><identifier>PMID: 36795955</identifier><language>eng</language><publisher>United States</publisher><subject>Aged, 80 and over ; Aging ; Brain ; Centenarians ; cognition ; dementia ; Dementia - diagnosis ; Dementia - epidemiology ; Humans ; Longitudinal Studies ; neuropathological changes ; nonagenarians</subject><ispartof>Alzheimer's & dementia, 2023-08, Vol.19 (8), p.3417-3425</ispartof><rights>2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4161-bc3f49baa5159d3cd239dc4495c83d1fd0bd05d25b7e6f189ea50a091fa172d43</citedby><cites>FETCH-LOGICAL-c4161-bc3f49baa5159d3cd239dc4495c83d1fd0bd05d25b7e6f189ea50a091fa172d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Falz.12981$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Falz.12981$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36795955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Neuville, Raumin S.</creatorcontrib><creatorcontrib>Biswas, Roshni</creatorcontrib><creatorcontrib>Ho, Chu‐Ching</creatorcontrib><creatorcontrib>Bukhari, Syed</creatorcontrib><creatorcontrib>Sajjadi, Seyed Ahmad</creatorcontrib><creatorcontrib>Paganini‐Hill, Annlia</creatorcontrib><creatorcontrib>Montine, Thomas J.</creatorcontrib><creatorcontrib>Corrada, María M.</creatorcontrib><creatorcontrib>Kawas, Claudia H.</creatorcontrib><title>Study of neuropathological changes and dementia in 100 centenarians in The 90+ Study</title><title>Alzheimer's & dementia</title><addtitle>Alzheimers Dement</addtitle><description>INTRODUCTION
The association between neuropathological changes and dementia among centenarians and nonagenarians remains unclear.
METHODS
We examined brain tissue from 100 centenarians and 297 nonagenarians from The 90+ Study, a community‐based longitudinal study of aging. We determined the prevalence of 10 neuropathological changes and compared their associations with dementia and cognitive performance between centenarians and nonagenarians.
RESULTS
A total of 59% of centenarians and 47% of nonagenarians had at least four neuropathological changes. In centenarians, neuropathological changes were associated with higher odds of dementia and, compared to nonagenarians, the odds were not attenuated. For each additional neuropathological change, the Mini‐Mental State Examination score was lower by 2 points for both groups.
DISCUSSION
Neuropathological changes continue to be strongly related to dementia in centenarians, highlighting the importance of slowing or preventing the development of multiple neuropathological changes in the aging brain to maintain cognitive health.
Highlights
Individual and multiple neuropathological changes are frequent in centenarians.
These neuropathological changes are strongly associated with dementia.
There is no attenuation of this association with age.</description><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Brain</subject><subject>Centenarians</subject><subject>cognition</subject><subject>dementia</subject><subject>Dementia - diagnosis</subject><subject>Dementia - epidemiology</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>neuropathological changes</subject><subject>nonagenarians</subject><issn>1552-5260</issn><issn>1552-5279</issn><issn>1552-5279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kc9PwjAUxxujEUQP_gOmR40B2m7d1pMhxF8JiQfx4qV5azuoGS2uTIN_vYMh0YOntq-ffN7L-yJ0TsmAEsKGUH4NKBMZPUBdyjnrc5aKw_09IR10EsIbITHJKD9GnShJBRecd9H0eVXrNfYFdqau_BJWc1_6mVVQYjUHNzMBg9NYm4VxKwvYOtz0xKp5GQeVBRc2tencYEGu8VZ3io4KKIM525099HJ3Ox0_9CdP94_j0aSvYprQfq6iIhY5AKdc6EhpFgmt4lhwlUWaFprkmnDNeJ6apKCZMMAJEEELoCnTcdRDN613WecLozczVVDKZWUXUK2lByv__jg7lzP_ISmJWZpGvDFc7gyVf69NWMmFDcqUJTjj6yBZmiVEZHFKGvSqRVXlQ6hMse9DidzEIJsY5DaGhr34Pdie_Nl7Awxb4NOWZv2_SY4mr63yG2kskhs</recordid><startdate>202308</startdate><enddate>202308</enddate><creator>Neuville, Raumin S.</creator><creator>Biswas, Roshni</creator><creator>Ho, Chu‐Ching</creator><creator>Bukhari, Syed</creator><creator>Sajjadi, Seyed Ahmad</creator><creator>Paganini‐Hill, Annlia</creator><creator>Montine, Thomas J.</creator><creator>Corrada, María M.</creator><creator>Kawas, Claudia H.</creator><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202308</creationdate><title>Study of neuropathological changes and dementia in 100 centenarians in The 90+ Study</title><author>Neuville, Raumin S. ; Biswas, Roshni ; Ho, Chu‐Ching ; Bukhari, Syed ; Sajjadi, Seyed Ahmad ; Paganini‐Hill, Annlia ; Montine, Thomas J. ; Corrada, María M. ; Kawas, Claudia H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4161-bc3f49baa5159d3cd239dc4495c83d1fd0bd05d25b7e6f189ea50a091fa172d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Brain</topic><topic>Centenarians</topic><topic>cognition</topic><topic>dementia</topic><topic>Dementia - diagnosis</topic><topic>Dementia - epidemiology</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>neuropathological changes</topic><topic>nonagenarians</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neuville, Raumin S.</creatorcontrib><creatorcontrib>Biswas, Roshni</creatorcontrib><creatorcontrib>Ho, Chu‐Ching</creatorcontrib><creatorcontrib>Bukhari, Syed</creatorcontrib><creatorcontrib>Sajjadi, Seyed Ahmad</creatorcontrib><creatorcontrib>Paganini‐Hill, Annlia</creatorcontrib><creatorcontrib>Montine, Thomas J.</creatorcontrib><creatorcontrib>Corrada, María M.</creatorcontrib><creatorcontrib>Kawas, Claudia H.</creatorcontrib><collection>Open Access: Wiley-Blackwell Open Access Journals</collection><collection>Wiley-Blackwell Open Access Backfiles</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Alzheimer's & dementia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neuville, Raumin S.</au><au>Biswas, Roshni</au><au>Ho, Chu‐Ching</au><au>Bukhari, Syed</au><au>Sajjadi, Seyed Ahmad</au><au>Paganini‐Hill, Annlia</au><au>Montine, Thomas J.</au><au>Corrada, María M.</au><au>Kawas, Claudia H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study of neuropathological changes and dementia in 100 centenarians in The 90+ Study</atitle><jtitle>Alzheimer's & dementia</jtitle><addtitle>Alzheimers Dement</addtitle><date>2023-08</date><risdate>2023</risdate><volume>19</volume><issue>8</issue><spage>3417</spage><epage>3425</epage><pages>3417-3425</pages><issn>1552-5260</issn><issn>1552-5279</issn><eissn>1552-5279</eissn><abstract>INTRODUCTION
The association between neuropathological changes and dementia among centenarians and nonagenarians remains unclear.
METHODS
We examined brain tissue from 100 centenarians and 297 nonagenarians from The 90+ Study, a community‐based longitudinal study of aging. We determined the prevalence of 10 neuropathological changes and compared their associations with dementia and cognitive performance between centenarians and nonagenarians.
RESULTS
A total of 59% of centenarians and 47% of nonagenarians had at least four neuropathological changes. In centenarians, neuropathological changes were associated with higher odds of dementia and, compared to nonagenarians, the odds were not attenuated. For each additional neuropathological change, the Mini‐Mental State Examination score was lower by 2 points for both groups.
DISCUSSION
Neuropathological changes continue to be strongly related to dementia in centenarians, highlighting the importance of slowing or preventing the development of multiple neuropathological changes in the aging brain to maintain cognitive health.
Highlights
Individual and multiple neuropathological changes are frequent in centenarians.
These neuropathological changes are strongly associated with dementia.
There is no attenuation of this association with age.</abstract><cop>United States</cop><pmid>36795955</pmid><doi>10.1002/alz.12981</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Blackwell Journals |
| subjects | Aged, 80 and over Aging Brain Centenarians cognition dementia Dementia - diagnosis Dementia - epidemiology Humans Longitudinal Studies neuropathological changes nonagenarians |
| title | Study of neuropathological changes and dementia in 100 centenarians in The 90+ Study |
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