Structural and spectroscopic characterization of RufO indicates a new biological role in rufomycin biosynthesis

Rufomycins constitute a class of cyclic heptapeptides isolated from actinomycetes. They are secondary metabolites that show promising treatment against Mycobacterium tuberculosis infections by inhibiting a novel drug target. Several nonproteinogenic amino acids are integrated into rufomycins, includ...

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Veröffentlicht in:	The Journal of biological chemistry 2023-08, Vol.299 (8), p.105049-105049, Article 105049
Hauptverfasser:	Jordan, Stephanie, Li, Bingnan, Traore, Ephrahime, Wu, Yifei, Usai, Remigio, Liu, Aimin, Xie, Zhong-Ru, Wang, Yifan
Format:	Artikel
Sprache:	eng
Schlagworte:	cytochrome P450 heme-dependent catalysis nonribosomal peptide synthesis rufomycin tyrosyl nitration
Online-Zugang:	Volltext
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