Cross-Training and Resistance Training in Adults with Type B Acute Lymphoblastic Leukemia during the Induction Phase: A Randomized Blind Pilot Study
Patients with acute lymphoblastic leukemia (ALL) undergoing induction decrease their physical capacity, lose muscle mass, and decrease their quality of life (QOL). The safety, feasibility, and benefits of exercise during chemotherapy have been proven, but the effects of cross-training activities hav...
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| Veröffentlicht in: | Journal of clinical medicine 2023-07, Vol.12 (15), p.5008 |
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| creator | Gallardo-Rodríguez, Adán Germán Fuchs-Tarlovsky, Vanessa Ocharán-Hernández, María Esther Ramos-Peñafiel, Christian Omar |
| description | Patients with acute lymphoblastic leukemia (ALL) undergoing induction decrease their physical capacity, lose muscle mass, and decrease their quality of life (QOL). The safety, feasibility, and benefits of exercise during chemotherapy have been proven, but the effects of cross-training activities have yet to be analyzed. To measure the effects of cross-training on body composition, physical performance, and QOL, a blind randomized clinical trial was carried out. A total of 33 patients were included and randomized into a cross-training exercise group (CEG), a resistance exercise group (REG), and a control group (CG). During induction, patients received an exercise routine three to five days a week for 30 to 50 min each. Body composition, QOL, and physical performance were measured at baseline, up to discharge, and at a follow-up of two months. Body composition improved in the REG and CEG. In the CG, muscle mass decreased and fat mass increased (
= 0.020 and 0.020, respectively). The REG and CEG had significant positive improvements in physical performance compared to the CG. QOL showed no differences in any group (
= 0.340). Cross-training and resistance exercise are essential to improve body composition and physical performance during induction. Considering the prognostic value of physical performance, we propose integrated training exercises as adjuvant therapy in adult patients with ALL. |
| doi_str_mv | 10.3390/jcm12155008 |
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= 0.020 and 0.020, respectively). The REG and CEG had significant positive improvements in physical performance compared to the CG. QOL showed no differences in any group (
= 0.340). Cross-training and resistance exercise are essential to improve body composition and physical performance during induction. Considering the prognostic value of physical performance, we propose integrated training exercises as adjuvant therapy in adult patients with ALL.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm12155008</identifier><identifier>PMID: 37568410</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acute lymphocytic leukemia ; Adults ; Body composition ; Bone marrow ; Cancer therapies ; Care and treatment ; Clinical medicine ; Cross-training (Athletics) ; Electrodes ; Exercise ; Exercise therapy ; Health aspects ; Hematology ; Hospitals ; Leukemia ; Medical prognosis ; Nervous system ; Patients ; Physical fitness ; Pilot projects ; Quality of life ; Strength training ; Testing ; Weight training</subject><ispartof>Journal of clinical medicine, 2023-07, Vol.12 (15), p.5008</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-4fa40a7f530c71bce2771dbee57e4654ddc8f35b91a661f49037c34eeee8eaf23</citedby><cites>FETCH-LOGICAL-c477t-4fa40a7f530c71bce2771dbee57e4654ddc8f35b91a661f49037c34eeee8eaf23</cites><orcidid>0000-0003-0957-9090</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419892/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419892/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37568410$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gallardo-Rodríguez, Adán Germán</creatorcontrib><creatorcontrib>Fuchs-Tarlovsky, Vanessa</creatorcontrib><creatorcontrib>Ocharán-Hernández, María Esther</creatorcontrib><creatorcontrib>Ramos-Peñafiel, Christian Omar</creatorcontrib><title>Cross-Training and Resistance Training in Adults with Type B Acute Lymphoblastic Leukemia during the Induction Phase: A Randomized Blind Pilot Study</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Patients with acute lymphoblastic leukemia (ALL) undergoing induction decrease their physical capacity, lose muscle mass, and decrease their quality of life (QOL). The safety, feasibility, and benefits of exercise during chemotherapy have been proven, but the effects of cross-training activities have yet to be analyzed. To measure the effects of cross-training on body composition, physical performance, and QOL, a blind randomized clinical trial was carried out. A total of 33 patients were included and randomized into a cross-training exercise group (CEG), a resistance exercise group (REG), and a control group (CG). During induction, patients received an exercise routine three to five days a week for 30 to 50 min each. Body composition, QOL, and physical performance were measured at baseline, up to discharge, and at a follow-up of two months. Body composition improved in the REG and CEG. In the CG, muscle mass decreased and fat mass increased (
= 0.020 and 0.020, respectively). The REG and CEG had significant positive improvements in physical performance compared to the CG. QOL showed no differences in any group (
= 0.340). Cross-training and resistance exercise are essential to improve body composition and physical performance during induction. Considering the prognostic value of physical performance, we propose integrated training exercises as adjuvant therapy in adult patients with ALL.</description><subject>Acute lymphocytic leukemia</subject><subject>Adults</subject><subject>Body composition</subject><subject>Bone marrow</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Clinical medicine</subject><subject>Cross-training (Athletics)</subject><subject>Electrodes</subject><subject>Exercise</subject><subject>Exercise therapy</subject><subject>Health aspects</subject><subject>Hematology</subject><subject>Hospitals</subject><subject>Leukemia</subject><subject>Medical prognosis</subject><subject>Nervous system</subject><subject>Patients</subject><subject>Physical fitness</subject><subject>Pilot projects</subject><subject>Quality of life</subject><subject>Strength training</subject><subject>Testing</subject><subject>Weight training</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkk1v1DAQhiMEolXpiTuyxAUJbbHjOHa4oHTFR6WVqMpythx7svGS2NvYAS2_gx-Mo5ZlixgfbI2feccznix7TvAFpRV-s9UDyQljGItH2WmOOV9gKujjo_NJdh7CFicTosgJf5qdUM5KURB8mv1ajj6ExXpU1lm3QcoZdAPBhqicBnTwW4dqM_UxoB82dmi93wG6RLWeIqDVfth1vulViFajFUzfYLAKmWmcI2MH6MqZSUfrHbruVIC3qEY3KZMf7E8w6LK3Keu17X1EX-Jk9s-yJ63qA5zf72fZ1w_v18tPi9Xnj1fLerXQBedxUbSqwIq3jGLNSaMh55yYBoBxKEpWGKNFS1lTEVWWpC0qTLmmBSQToNqcnmXv7nR3UzOA0eDiqHq5G-2gxr30ysqHN852cuO_S4ILUolqVnh1rzD62wlClIMNGvpeOfBTkLlgmOKSCJLQl_-gWz-NLtWXqPQ2UlaM_6U2qgdpXetTYj2LypqXmJESc5qoi_9QaZnUee0dtDb5HwS8vgvQ83eP0B6KJFjOgySPBinRL477cmD_jA39DY4cw_Y</recordid><startdate>20230730</startdate><enddate>20230730</enddate><creator>Gallardo-Rodríguez, Adán Germán</creator><creator>Fuchs-Tarlovsky, Vanessa</creator><creator>Ocharán-Hernández, María Esther</creator><creator>Ramos-Peñafiel, Christian Omar</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0957-9090</orcidid></search><sort><creationdate>20230730</creationdate><title>Cross-Training and Resistance Training in Adults with Type B Acute Lymphoblastic Leukemia during the Induction Phase: A Randomized Blind Pilot Study</title><author>Gallardo-Rodríguez, Adán Germán ; Fuchs-Tarlovsky, Vanessa ; Ocharán-Hernández, María Esther ; Ramos-Peñafiel, Christian Omar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-4fa40a7f530c71bce2771dbee57e4654ddc8f35b91a661f49037c34eeee8eaf23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acute lymphocytic leukemia</topic><topic>Adults</topic><topic>Body composition</topic><topic>Bone marrow</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Clinical medicine</topic><topic>Cross-training (Athletics)</topic><topic>Electrodes</topic><topic>Exercise</topic><topic>Exercise therapy</topic><topic>Health aspects</topic><topic>Hematology</topic><topic>Hospitals</topic><topic>Leukemia</topic><topic>Medical prognosis</topic><topic>Nervous system</topic><topic>Patients</topic><topic>Physical fitness</topic><topic>Pilot projects</topic><topic>Quality of life</topic><topic>Strength training</topic><topic>Testing</topic><topic>Weight training</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gallardo-Rodríguez, Adán Germán</creatorcontrib><creatorcontrib>Fuchs-Tarlovsky, Vanessa</creatorcontrib><creatorcontrib>Ocharán-Hernández, María Esther</creatorcontrib><creatorcontrib>Ramos-Peñafiel, Christian Omar</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gallardo-Rodríguez, Adán Germán</au><au>Fuchs-Tarlovsky, Vanessa</au><au>Ocharán-Hernández, María Esther</au><au>Ramos-Peñafiel, Christian Omar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cross-Training and Resistance Training in Adults with Type B Acute Lymphoblastic Leukemia during the Induction Phase: A Randomized Blind Pilot Study</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2023-07-30</date><risdate>2023</risdate><volume>12</volume><issue>15</issue><spage>5008</spage><pages>5008-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Patients with acute lymphoblastic leukemia (ALL) undergoing induction decrease their physical capacity, lose muscle mass, and decrease their quality of life (QOL). The safety, feasibility, and benefits of exercise during chemotherapy have been proven, but the effects of cross-training activities have yet to be analyzed. To measure the effects of cross-training on body composition, physical performance, and QOL, a blind randomized clinical trial was carried out. A total of 33 patients were included and randomized into a cross-training exercise group (CEG), a resistance exercise group (REG), and a control group (CG). During induction, patients received an exercise routine three to five days a week for 30 to 50 min each. Body composition, QOL, and physical performance were measured at baseline, up to discharge, and at a follow-up of two months. Body composition improved in the REG and CEG. In the CG, muscle mass decreased and fat mass increased (
= 0.020 and 0.020, respectively). The REG and CEG had significant positive improvements in physical performance compared to the CG. QOL showed no differences in any group (
= 0.340). Cross-training and resistance exercise are essential to improve body composition and physical performance during induction. Considering the prognostic value of physical performance, we propose integrated training exercises as adjuvant therapy in adult patients with ALL.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37568410</pmid><doi>10.3390/jcm12155008</doi><orcidid>https://orcid.org/0000-0003-0957-9090</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acute lymphocytic leukemia Adults Body composition Bone marrow Cancer therapies Care and treatment Clinical medicine Cross-training (Athletics) Electrodes Exercise Exercise therapy Health aspects Hematology Hospitals Leukemia Medical prognosis Nervous system Patients Physical fitness Pilot projects Quality of life Strength training Testing Weight training |
| title | Cross-Training and Resistance Training in Adults with Type B Acute Lymphoblastic Leukemia during the Induction Phase: A Randomized Blind Pilot Study |
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