Serum and Saliva Level of miR-31-5p and miR-let 7a in EBV Associated Oropharyngeal Cancer
Epstein-Barr virus (EBV) has a well-documented association with head and neck neoplasms, including nasopharyngeal carcinoma (NPC). In the last few years, research aimed at elucidating the role of the miRs in the pathogenesis of head and neck cancer (HNC) has gained importance. The study of miRs expr...
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| Veröffentlicht in: | International journal of molecular sciences 2023-07, Vol.24 (15), p.11965 |
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| description | Epstein-Barr virus (EBV) has a well-documented association with head and neck neoplasms, including nasopharyngeal carcinoma (NPC). In the last few years, research aimed at elucidating the role of the miRs in the pathogenesis of head and neck cancer (HNC) has gained importance. The study of miRs expression has set new directions in the search for biomarkers with diagnostic and prognostic value, and even in the search for new therapeutic targets for various tumors, including HNC. The aim of current study was to approximate the importance of miR-31-5p and miR-let 7a in the pathogenesis of EBV associated oropharyngeal cancer. For this purpose, experiments were carried out to determine the level of mentioned miRs in serum among patients diagnosed with oropharyngeal cancer linked to EBV infection, depending on histological differentiation-grading (G1-G3) and TNM classification. All clinical specimens stratified by HPV status were HPV negative. The level of antibodies EBNA and EBVCA was also assessed. The obtained results showed a significantly increased serum level of miR-31-5p but decreased level of miR-let 7a in EBV positive oropharyngeal cancer patients. We demonstrated association between the level of tested miRs and clinical stage. Our findings showed that miR-31-5p and miR-let-7a may be involved in development and progression of EBV associated oropharyngeal cancer. Therefore, it seems important to further study these molecules, as well as to determine whether they could be important biomarkers in the diagnosis of oropharyngeal cancer associated with EBV infection. |
| doi_str_mv | 10.3390/ijms241511965 |
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In the last few years, research aimed at elucidating the role of the miRs in the pathogenesis of head and neck cancer (HNC) has gained importance. The study of miRs expression has set new directions in the search for biomarkers with diagnostic and prognostic value, and even in the search for new therapeutic targets for various tumors, including HNC. The aim of current study was to approximate the importance of miR-31-5p and miR-let 7a in the pathogenesis of EBV associated oropharyngeal cancer. For this purpose, experiments were carried out to determine the level of mentioned miRs in serum among patients diagnosed with oropharyngeal cancer linked to EBV infection, depending on histological differentiation-grading (G1-G3) and TNM classification. All clinical specimens stratified by HPV status were HPV negative. The level of antibodies EBNA and EBVCA was also assessed. The obtained results showed a significantly increased serum level of miR-31-5p but decreased level of miR-let 7a in EBV positive oropharyngeal cancer patients. We demonstrated association between the level of tested miRs and clinical stage. Our findings showed that miR-31-5p and miR-let-7a may be involved in development and progression of EBV associated oropharyngeal cancer. Therefore, it seems important to further study these molecules, as well as to determine whether they could be important biomarkers in the diagnosis of oropharyngeal cancer associated with EBV infection.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms241511965</identifier><identifier>PMID: 37569339</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antibodies ; Biomarkers ; Development and progression ; Disease ; Epstein-Barr virus ; Head & neck cancer ; Human papillomavirus ; Infections ; Lymphatic system ; Medical prognosis ; Medical research ; MicroRNAs ; Mortality ; Oral cancer ; Papillomavirus infections ; Prognosis ; Throat cancer ; Tumors ; Viral antibodies</subject><ispartof>International journal of molecular sciences, 2023-07, Vol.24 (15), p.11965</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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In the last few years, research aimed at elucidating the role of the miRs in the pathogenesis of head and neck cancer (HNC) has gained importance. The study of miRs expression has set new directions in the search for biomarkers with diagnostic and prognostic value, and even in the search for new therapeutic targets for various tumors, including HNC. The aim of current study was to approximate the importance of miR-31-5p and miR-let 7a in the pathogenesis of EBV associated oropharyngeal cancer. For this purpose, experiments were carried out to determine the level of mentioned miRs in serum among patients diagnosed with oropharyngeal cancer linked to EBV infection, depending on histological differentiation-grading (G1-G3) and TNM classification. All clinical specimens stratified by HPV status were HPV negative. The level of antibodies EBNA and EBVCA was also assessed. The obtained results showed a significantly increased serum level of miR-31-5p but decreased level of miR-let 7a in EBV positive oropharyngeal cancer patients. We demonstrated association between the level of tested miRs and clinical stage. Our findings showed that miR-31-5p and miR-let-7a may be involved in development and progression of EBV associated oropharyngeal cancer. Therefore, it seems important to further study these molecules, as well as to determine whether they could be important biomarkers in the diagnosis of oropharyngeal cancer associated with EBV infection.</description><subject>Antibodies</subject><subject>Biomarkers</subject><subject>Development and progression</subject><subject>Disease</subject><subject>Epstein-Barr virus</subject><subject>Head & neck cancer</subject><subject>Human papillomavirus</subject><subject>Infections</subject><subject>Lymphatic system</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>MicroRNAs</subject><subject>Mortality</subject><subject>Oral cancer</subject><subject>Papillomavirus infections</subject><subject>Prognosis</subject><subject>Throat cancer</subject><subject>Tumors</subject><subject>Viral antibodies</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkstv1DAQxiMEoqVw5IosceGS4nfiE9quykNaqRIFJE7W1JlsvUrsxU5W4r_Hy5bSRcgHP-b3fZ6xp6peMnouhKFv_WbMXDLFmNHqUXXKJOc1pbp5_GB9Uj3LeUMpF1yZp9WJaJQ2RX5afb_GNI8EQkeuYfA7ICvc4UBiT0b_uRasVtvf0f1uwIk0QHwglxffyCLn6DxM2JGrFLe3kH6GNcJAlhAcpufVkx6GjC_u5rPq6_vLL8uP9erqw6flYlU7KcxUy5ISY4wy0AIk5UwLwzRqIQVwKvpGowSmqGoNcOjathd9wW8aQ6kEJ8RZ9e7gu51vRuwchinBYLfJjyUjG8Hb40jwt3Ydd5ZRydpG8-Lw5s4hxR8z5smOPjscBggY52x5q6hgWhpd0Nf_oJs4p1DqK5Q0VCupmr_UGga0PvSxXOz2pnbRaKqYOnid_4cqo8PRuxiw9-X8SFAfBC7FnBP290UyavfNYI-aofCvHr7MPf3n98UvIjeqjQ</recordid><startdate>20230726</startdate><enddate>20230726</enddate><creator>Polz, Anna</creator><creator>Morshed, Kamal</creator><creator>Bibik, Robert</creator><creator>Drop, Bartłomiej</creator><creator>Drop, Andrzej</creator><creator>Polz-Dacewicz, Małgorzata</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3222-184X</orcidid><orcidid>https://orcid.org/0000-0003-0061-0362</orcidid></search><sort><creationdate>20230726</creationdate><title>Serum and Saliva Level of miR-31-5p and miR-let 7a in EBV Associated Oropharyngeal Cancer</title><author>Polz, Anna ; Morshed, Kamal ; Bibik, Robert ; Drop, Bartłomiej ; Drop, Andrzej ; Polz-Dacewicz, Małgorzata</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-432511101a63a402163916e6343a203f76e4a150589a2ad88f3f110b79004ac33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antibodies</topic><topic>Biomarkers</topic><topic>Development and progression</topic><topic>Disease</topic><topic>Epstein-Barr virus</topic><topic>Head & neck cancer</topic><topic>Human papillomavirus</topic><topic>Infections</topic><topic>Lymphatic system</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>MicroRNAs</topic><topic>Mortality</topic><topic>Oral cancer</topic><topic>Papillomavirus infections</topic><topic>Prognosis</topic><topic>Throat cancer</topic><topic>Tumors</topic><topic>Viral antibodies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Polz, Anna</creatorcontrib><creatorcontrib>Morshed, Kamal</creatorcontrib><creatorcontrib>Bibik, Robert</creatorcontrib><creatorcontrib>Drop, Bartłomiej</creatorcontrib><creatorcontrib>Drop, Andrzej</creatorcontrib><creatorcontrib>Polz-Dacewicz, Małgorzata</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Polz, Anna</au><au>Morshed, Kamal</au><au>Bibik, Robert</au><au>Drop, Bartłomiej</au><au>Drop, Andrzej</au><au>Polz-Dacewicz, Małgorzata</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum and Saliva Level of miR-31-5p and miR-let 7a in EBV Associated Oropharyngeal Cancer</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2023-07-26</date><risdate>2023</risdate><volume>24</volume><issue>15</issue><spage>11965</spage><pages>11965-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Epstein-Barr virus (EBV) has a well-documented association with head and neck neoplasms, including nasopharyngeal carcinoma (NPC). In the last few years, research aimed at elucidating the role of the miRs in the pathogenesis of head and neck cancer (HNC) has gained importance. The study of miRs expression has set new directions in the search for biomarkers with diagnostic and prognostic value, and even in the search for new therapeutic targets for various tumors, including HNC. The aim of current study was to approximate the importance of miR-31-5p and miR-let 7a in the pathogenesis of EBV associated oropharyngeal cancer. For this purpose, experiments were carried out to determine the level of mentioned miRs in serum among patients diagnosed with oropharyngeal cancer linked to EBV infection, depending on histological differentiation-grading (G1-G3) and TNM classification. All clinical specimens stratified by HPV status were HPV negative. The level of antibodies EBNA and EBVCA was also assessed. The obtained results showed a significantly increased serum level of miR-31-5p but decreased level of miR-let 7a in EBV positive oropharyngeal cancer patients. We demonstrated association between the level of tested miRs and clinical stage. Our findings showed that miR-31-5p and miR-let-7a may be involved in development and progression of EBV associated oropharyngeal cancer. Therefore, it seems important to further study these molecules, as well as to determine whether they could be important biomarkers in the diagnosis of oropharyngeal cancer associated with EBV infection.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37569339</pmid><doi>10.3390/ijms241511965</doi><orcidid>https://orcid.org/0000-0002-3222-184X</orcidid><orcidid>https://orcid.org/0000-0003-0061-0362</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antibodies Biomarkers Development and progression Disease Epstein-Barr virus Head & neck cancer Human papillomavirus Infections Lymphatic system Medical prognosis Medical research MicroRNAs Mortality Oral cancer Papillomavirus infections Prognosis Throat cancer Tumors Viral antibodies |
| title | Serum and Saliva Level of miR-31-5p and miR-let 7a in EBV Associated Oropharyngeal Cancer |
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