Design, Synthesis, and Biological Evaluation of New Potential Unusual Modified Anticancer Immunomodulators for Possible Non-Teratogenic Quinazoline-Based Thalidomide Analogs

Sixteen new thalidomide analogs were synthesized. The new candidates showed potent in vitro antiproliferative activities against three human cancer cell lines, namely hepatocellular carcinoma (HepG-2), prostate cancer (PC3), and breast cancer (MCF-7). It was found that compounds XII, XIIIa, XIIIb, X...

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Veröffentlicht in:	International journal of molecular sciences 2023-08, Vol.24 (15), p.12416
Hauptverfasser:	Mabrouk, Reda R, Abdallah, Abdallah E, Mahdy, Hazem A, El-Kalyoubi, Samar A, Kamal, Omar Jamal, Abdelghany, Tamer M, Zayed, Mohamed F, Alshaeri, Heba K, Alasmari, Moudi M, El-Zahabi, Mohamed Ayman
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Breast cancer Cancer Care and treatment Cell cycle Comparative analysis Erythema FDA approval Fibroblasts Growth factors Hydrogen bonds Immunomodulators Prostate cancer Thalidomide Tumor necrosis factor Tumor necrosis factor-TNF Vascular endothelial growth factor
Online-Zugang:	Volltext
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