Dysbindin Domain-Containing 1 in Prostate Cancer: New Insights into Bioinformatic Validation of Molecular and Immunological Features
Prostate cancer (PCa) is one of the most prevalent cancers in men, yet its pathogenic pathways remain poorly understood. Transcriptomics and high-throughput sequencing can help uncover cancer diagnostic targets and understand biological circuits. Using prostate adenocarcinoma (PRAD) datasets of vari...
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| Veröffentlicht in: | International journal of molecular sciences 2023-07, Vol.24 (15), p.11930 |
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| description | Prostate cancer (PCa) is one of the most prevalent cancers in men, yet its pathogenic pathways remain poorly understood. Transcriptomics and high-throughput sequencing can help uncover cancer diagnostic targets and understand biological circuits. Using prostate adenocarcinoma (PRAD) datasets of various web-based applications (GEPIA, UALCAN, cBioPortal, SR Plot, hTFtarget, Genome Browser, and MetaCore), we found that upregulated dysbindin domain-containing 1 (
) expression in primary prostate tumors was strongly correlated with pathways involving the cell cycle, mitotic in KEGG, WIKI, and REACTOME database, and transcription factor-binding sites with the
gene in prostate samples.
gene expression was influenced by sample type, cancer stage, and promoter methylation levels of different cancers, such as PRAD, liver hepatocellular carcinoma (LIHC), and lung adenocarcinoma (LUAD). Regulation of glycogen synthase kinase (GSK)-3β in bipolar disorder and ATP/ITP/GTP/XTP/TTP/CTP/UTP metabolic pathways was closely correlated with the
gene and its co-expressed genes in PCa.
gene expression was positively associated with immune infiltration of B cells, Myeloid-derived suppressor cell (MDSC), M2 macrophages, andneutrophil, whereas negatively correlated with CD8
T cells, T follicular helper cells, M1 macrophages, and NK cells in PCa. These findings suggest that DBNDD1 may serve as a viable prognostic marker not only for early-stage PCa but also for immunotherapies. |
| doi_str_mv | 10.3390/ijms241511930 |
| format | Article |
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) expression in primary prostate tumors was strongly correlated with pathways involving the cell cycle, mitotic in KEGG, WIKI, and REACTOME database, and transcription factor-binding sites with the
gene in prostate samples.
gene expression was influenced by sample type, cancer stage, and promoter methylation levels of different cancers, such as PRAD, liver hepatocellular carcinoma (LIHC), and lung adenocarcinoma (LUAD). Regulation of glycogen synthase kinase (GSK)-3β in bipolar disorder and ATP/ITP/GTP/XTP/TTP/CTP/UTP metabolic pathways was closely correlated with the
gene and its co-expressed genes in PCa.
gene expression was positively associated with immune infiltration of B cells, Myeloid-derived suppressor cell (MDSC), M2 macrophages, andneutrophil, whereas negatively correlated with CD8
T cells, T follicular helper cells, M1 macrophages, and NK cells in PCa. These findings suggest that DBNDD1 may serve as a viable prognostic marker not only for early-stage PCa but also for immunotherapies.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms241511930</identifier><identifier>PMID: 37569304</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Biomarkers ; Cancer therapies ; Chromosomes ; Colorectal cancer ; Datasets ; Development and progression ; DNA methylation ; Epidemiology ; Gene expression ; Genomes ; Immunotherapy ; Kinases ; Liver cancer ; Lung cancer ; Lymphocytes ; Medical prognosis ; Nervous system ; Pancreatic cancer ; Prostate cancer ; Proteins</subject><ispartof>International journal of molecular sciences, 2023-07, Vol.24 (15), p.11930</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c439t-65a1885ad49d4b31c565e9dfc90beac4beddf11d137dff990c9aae608297b19d3</cites><orcidid>0000-0001-8809-239X ; 0000-0002-0902-3968 ; 0000-0002-4137-5074 ; 0000-0002-3102-8482</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418609/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418609/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37569304$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tram, Van Thi Ngoc</creatorcontrib><creatorcontrib>Khoa Ta, Hoang Dang</creatorcontrib><creatorcontrib>Anuraga, Gangga</creatorcontrib><creatorcontrib>Dung, Phan Vu Thuy</creatorcontrib><creatorcontrib>Xuan, Do Thi Minh</creatorcontrib><creatorcontrib>Dey, Sanskriti</creatorcontrib><creatorcontrib>Wang, Chih-Yang</creatorcontrib><creatorcontrib>Liu, Yen-Nien</creatorcontrib><title>Dysbindin Domain-Containing 1 in Prostate Cancer: New Insights into Bioinformatic Validation of Molecular and Immunological Features</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Prostate cancer (PCa) is one of the most prevalent cancers in men, yet its pathogenic pathways remain poorly understood. Transcriptomics and high-throughput sequencing can help uncover cancer diagnostic targets and understand biological circuits. Using prostate adenocarcinoma (PRAD) datasets of various web-based applications (GEPIA, UALCAN, cBioPortal, SR Plot, hTFtarget, Genome Browser, and MetaCore), we found that upregulated dysbindin domain-containing 1 (
) expression in primary prostate tumors was strongly correlated with pathways involving the cell cycle, mitotic in KEGG, WIKI, and REACTOME database, and transcription factor-binding sites with the
gene in prostate samples.
gene expression was influenced by sample type, cancer stage, and promoter methylation levels of different cancers, such as PRAD, liver hepatocellular carcinoma (LIHC), and lung adenocarcinoma (LUAD). Regulation of glycogen synthase kinase (GSK)-3β in bipolar disorder and ATP/ITP/GTP/XTP/TTP/CTP/UTP metabolic pathways was closely correlated with the
gene and its co-expressed genes in PCa.
gene expression was positively associated with immune infiltration of B cells, Myeloid-derived suppressor cell (MDSC), M2 macrophages, andneutrophil, whereas negatively correlated with CD8
T cells, T follicular helper cells, M1 macrophages, and NK cells in PCa. These findings suggest that DBNDD1 may serve as a viable prognostic marker not only for early-stage PCa but also for immunotherapies.</description><subject>Biomarkers</subject><subject>Cancer therapies</subject><subject>Chromosomes</subject><subject>Colorectal cancer</subject><subject>Datasets</subject><subject>Development and progression</subject><subject>DNA methylation</subject><subject>Epidemiology</subject><subject>Gene expression</subject><subject>Genomes</subject><subject>Immunotherapy</subject><subject>Kinases</subject><subject>Liver cancer</subject><subject>Lung cancer</subject><subject>Lymphocytes</subject><subject>Medical prognosis</subject><subject>Nervous system</subject><subject>Pancreatic cancer</subject><subject>Prostate cancer</subject><subject>Proteins</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkj1vFDEQhlcIREKgpEWWaGg22OuPPdOgcCFwUvgogNaatb0bn7x2sL2g9PxwfEoIOYRczGj8zGvN-G2apwQfUyrxS7edc8cIJ0RSfK85JKzrWoxFf_9OftA8ynmLcUc7Lh82B7TnouLssPl1epUHF4wL6DTO4EK7jqHU6MKECKrlzynmAsWiNQRt0yv00f5Em5DddFFyBUpEb1x0YYxphuI0-gbemZrFgOKIPkRv9eIhIQgGbeZ5CdHHyWnw6MxCWZLNj5sHI_hsn9zEo-br2dsv6_ft-ad3m_XJeasZlaUVHMhqxcEwadhAieaCW2lGLfFgQbPBGjMSYgjtzThKibUEsAKvOtkPRBp61Ly-1r1chtkabUNJ4NVlcjOkKxXBqf2b4C7UFH8oghlZCSyrwosbhRS_LzYXNbusrfcQbFyy6lYcUyI63lf0-T_oNi4p1PkqxSQWFWN_qQm8Vbst1of1TlSd9AJzwpkglTr-D1WPsbPTMdjR1fpeQ3vdoOvv5WTH2yEJVjvfqD3fVP7Z3c3c0n-MQn8D1oe_rA</recordid><startdate>20230725</startdate><enddate>20230725</enddate><creator>Tram, Van Thi Ngoc</creator><creator>Khoa Ta, Hoang Dang</creator><creator>Anuraga, Gangga</creator><creator>Dung, Phan Vu Thuy</creator><creator>Xuan, Do Thi Minh</creator><creator>Dey, Sanskriti</creator><creator>Wang, Chih-Yang</creator><creator>Liu, Yen-Nien</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8809-239X</orcidid><orcidid>https://orcid.org/0000-0002-0902-3968</orcidid><orcidid>https://orcid.org/0000-0002-4137-5074</orcidid><orcidid>https://orcid.org/0000-0002-3102-8482</orcidid></search><sort><creationdate>20230725</creationdate><title>Dysbindin Domain-Containing 1 in Prostate Cancer: New Insights into Bioinformatic Validation of Molecular and Immunological Features</title><author>Tram, Van Thi Ngoc ; 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Transcriptomics and high-throughput sequencing can help uncover cancer diagnostic targets and understand biological circuits. Using prostate adenocarcinoma (PRAD) datasets of various web-based applications (GEPIA, UALCAN, cBioPortal, SR Plot, hTFtarget, Genome Browser, and MetaCore), we found that upregulated dysbindin domain-containing 1 (
) expression in primary prostate tumors was strongly correlated with pathways involving the cell cycle, mitotic in KEGG, WIKI, and REACTOME database, and transcription factor-binding sites with the
gene in prostate samples.
gene expression was influenced by sample type, cancer stage, and promoter methylation levels of different cancers, such as PRAD, liver hepatocellular carcinoma (LIHC), and lung adenocarcinoma (LUAD). Regulation of glycogen synthase kinase (GSK)-3β in bipolar disorder and ATP/ITP/GTP/XTP/TTP/CTP/UTP metabolic pathways was closely correlated with the
gene and its co-expressed genes in PCa.
gene expression was positively associated with immune infiltration of B cells, Myeloid-derived suppressor cell (MDSC), M2 macrophages, andneutrophil, whereas negatively correlated with CD8
T cells, T follicular helper cells, M1 macrophages, and NK cells in PCa. These findings suggest that DBNDD1 may serve as a viable prognostic marker not only for early-stage PCa but also for immunotherapies.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37569304</pmid><doi>10.3390/ijms241511930</doi><orcidid>https://orcid.org/0000-0001-8809-239X</orcidid><orcidid>https://orcid.org/0000-0002-0902-3968</orcidid><orcidid>https://orcid.org/0000-0002-4137-5074</orcidid><orcidid>https://orcid.org/0000-0002-3102-8482</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biomarkers Cancer therapies Chromosomes Colorectal cancer Datasets Development and progression DNA methylation Epidemiology Gene expression Genomes Immunotherapy Kinases Liver cancer Lung cancer Lymphocytes Medical prognosis Nervous system Pancreatic cancer Prostate cancer Proteins |
| title | Dysbindin Domain-Containing 1 in Prostate Cancer: New Insights into Bioinformatic Validation of Molecular and Immunological Features |
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