Expression and Regulatory Mechanisms of MicroRNA in Cholesteatoma: A Systematic Review
Cholesteatoma is a temporal bone disease characterized by dysfunctions of keratinocytes. MicroRNAs (miRNAs) are evolutionary conserved noncoding RNAs that regulate mRNA expression. They can be packaged into exosomes and transported to target cells that can be used in the future therapy of cholesteat...
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| Veröffentlicht in: | International journal of molecular sciences 2023-07, Vol.24 (15), p.12277 |
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| description | Cholesteatoma is a temporal bone disease characterized by dysfunctions of keratinocytes. MicroRNAs (miRNAs) are evolutionary conserved noncoding RNAs that regulate mRNA expression. They can be packaged into exosomes and transported to target cells that can be used in the future therapy of cholesteatoma. This study aimed to collect knowledge on the role of miRNAs and exosomal miRNAs in cholesteatoma and was conducted according to the PRISMA guidelines for systematic reviews. Four databases were screened: Pubmed/MEDLINE, Web of Science, Scopus, and the Cochrane Library. The last search was run on the 6th of June 2023. We included full-text original studies written in English, which examined miRNAs in cholesteatoma. The risk of bias was assessed using the Office of Health Assessment and Translation (OHAT) Risk of Bias Rating Tool, modified for the needs of this review. We identified 118 records and included 18 articles. Analyses revealed the downregulation of exosomal miR-17 as well as miR-10a-5p, miR-125b, miR-142-5p, miR34a, miR-203a, and miR-152-5p and the overexpression of exosomal miR-106b-5p as well as miR-1297, miR-26a-5p, miR-199a, miR-508-3p, miR-21-3p, miR-584-5p, and miR-16-1-3p in cholesteatoma. The role of differentially expressed miRNAs in cholesteatoma, including cell proliferation, apoptosis, the cell cycle, differentiation, bone resorption, and the remodeling process, was confirmed, making them a potential therapeutic target in this disease. |
| doi_str_mv | 10.3390/ijms241512277 |
| format | Article |
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MicroRNAs (miRNAs) are evolutionary conserved noncoding RNAs that regulate mRNA expression. They can be packaged into exosomes and transported to target cells that can be used in the future therapy of cholesteatoma. This study aimed to collect knowledge on the role of miRNAs and exosomal miRNAs in cholesteatoma and was conducted according to the PRISMA guidelines for systematic reviews. Four databases were screened: Pubmed/MEDLINE, Web of Science, Scopus, and the Cochrane Library. The last search was run on the 6th of June 2023. We included full-text original studies written in English, which examined miRNAs in cholesteatoma. The risk of bias was assessed using the Office of Health Assessment and Translation (OHAT) Risk of Bias Rating Tool, modified for the needs of this review. We identified 118 records and included 18 articles. Analyses revealed the downregulation of exosomal miR-17 as well as miR-10a-5p, miR-125b, miR-142-5p, miR34a, miR-203a, and miR-152-5p and the overexpression of exosomal miR-106b-5p as well as miR-1297, miR-26a-5p, miR-199a, miR-508-3p, miR-21-3p, miR-584-5p, and miR-16-1-3p in cholesteatoma. The role of differentially expressed miRNAs in cholesteatoma, including cell proliferation, apoptosis, the cell cycle, differentiation, bone resorption, and the remodeling process, was confirmed, making them a potential therapeutic target in this disease.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms241512277</identifier><identifier>PMID: 37569652</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Analysis ; Apoptosis ; Cell cycle ; Cell differentiation ; Cholesteatoma ; Extracellular vesicles ; Fibroblasts ; Growth factors ; Health aspects ; Hearing loss ; Hearing protection ; MicroRNA ; MicroRNAs ; Pathogenesis ; Review ; Systematic review ; Tumor necrosis factor-TNF</subject><ispartof>International journal of molecular sciences, 2023-07, Vol.24 (15), p.12277</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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MicroRNAs (miRNAs) are evolutionary conserved noncoding RNAs that regulate mRNA expression. They can be packaged into exosomes and transported to target cells that can be used in the future therapy of cholesteatoma. This study aimed to collect knowledge on the role of miRNAs and exosomal miRNAs in cholesteatoma and was conducted according to the PRISMA guidelines for systematic reviews. Four databases were screened: Pubmed/MEDLINE, Web of Science, Scopus, and the Cochrane Library. The last search was run on the 6th of June 2023. We included full-text original studies written in English, which examined miRNAs in cholesteatoma. The risk of bias was assessed using the Office of Health Assessment and Translation (OHAT) Risk of Bias Rating Tool, modified for the needs of this review. We identified 118 records and included 18 articles. Analyses revealed the downregulation of exosomal miR-17 as well as miR-10a-5p, miR-125b, miR-142-5p, miR34a, miR-203a, and miR-152-5p and the overexpression of exosomal miR-106b-5p as well as miR-1297, miR-26a-5p, miR-199a, miR-508-3p, miR-21-3p, miR-584-5p, and miR-16-1-3p in cholesteatoma. The role of differentially expressed miRNAs in cholesteatoma, including cell proliferation, apoptosis, the cell cycle, differentiation, bone resorption, and the remodeling process, was confirmed, making them a potential therapeutic target in this disease.</description><subject>Analysis</subject><subject>Apoptosis</subject><subject>Cell cycle</subject><subject>Cell differentiation</subject><subject>Cholesteatoma</subject><subject>Extracellular vesicles</subject><subject>Fibroblasts</subject><subject>Growth factors</subject><subject>Health aspects</subject><subject>Hearing loss</subject><subject>Hearing protection</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>Pathogenesis</subject><subject>Review</subject><subject>Systematic review</subject><subject>Tumor necrosis factor-TNF</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkstvEzEQxleIij7gyBVZ4sJlW7_tcEFR1AJSC1J5XC3Xnk0c7drB3i3kv8dVn0HIB3vs33zWNzNN85rgY8Zm-CSsh0I5EYRSpZ41B4RT2mIs1fMn5_3msJQ1xpRRMXvR7DMl5EwKetD8PP2zyVBKSBHZ6NElLKfejilv0QW4lY2hDAWlDl0El9PllzkKES1WqYcyQuUG-x7N0bdtjQY7BlcFrgP8ftnsdbYv8OpuP2p-nJ1-X3xqz79-_LyYn7eOaza2jAHVXPgrp4h3klmLgXceS9BWgRTaEaqIYpZp6x0RHDxjhGhJlfbUMXbUfLjV3UxXA3gHccy2N5scBpu3Jtlgdl9iWJllujYEc6IZJ1Xh3Z1CTr-m6soMoTjoexshTcVQLTAjqla3om__QddpyrH6qxSfYam5Jo_U0vZgQuxS_djdiJq5klgQobGu1PF_qLo8DMGlCF2o9zsJ7W1CbUMpGboHkwSbm0kwO5NQ-TdPK_NA37ee_QW0kK1y</recordid><startdate>20230731</startdate><enddate>20230731</enddate><creator>Dżaman, Karolina</creator><creator>Czerwaty, Katarzyna</creator><creator>Reichert, Torsten E</creator><creator>Szczepański, Mirosław J</creator><creator>Ludwig, Nils</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1311-8377</orcidid><orcidid>https://orcid.org/0000-0001-5561-2184</orcidid><orcidid>https://orcid.org/0000-0002-5206-137X</orcidid></search><sort><creationdate>20230731</creationdate><title>Expression and Regulatory Mechanisms of MicroRNA in Cholesteatoma: A Systematic Review</title><author>Dżaman, Karolina ; 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MicroRNAs (miRNAs) are evolutionary conserved noncoding RNAs that regulate mRNA expression. They can be packaged into exosomes and transported to target cells that can be used in the future therapy of cholesteatoma. This study aimed to collect knowledge on the role of miRNAs and exosomal miRNAs in cholesteatoma and was conducted according to the PRISMA guidelines for systematic reviews. Four databases were screened: Pubmed/MEDLINE, Web of Science, Scopus, and the Cochrane Library. The last search was run on the 6th of June 2023. We included full-text original studies written in English, which examined miRNAs in cholesteatoma. The risk of bias was assessed using the Office of Health Assessment and Translation (OHAT) Risk of Bias Rating Tool, modified for the needs of this review. We identified 118 records and included 18 articles. Analyses revealed the downregulation of exosomal miR-17 as well as miR-10a-5p, miR-125b, miR-142-5p, miR34a, miR-203a, and miR-152-5p and the overexpression of exosomal miR-106b-5p as well as miR-1297, miR-26a-5p, miR-199a, miR-508-3p, miR-21-3p, miR-584-5p, and miR-16-1-3p in cholesteatoma. The role of differentially expressed miRNAs in cholesteatoma, including cell proliferation, apoptosis, the cell cycle, differentiation, bone resorption, and the remodeling process, was confirmed, making them a potential therapeutic target in this disease.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37569652</pmid><doi>10.3390/ijms241512277</doi><orcidid>https://orcid.org/0000-0003-1311-8377</orcidid><orcidid>https://orcid.org/0000-0001-5561-2184</orcidid><orcidid>https://orcid.org/0000-0002-5206-137X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Analysis Apoptosis Cell cycle Cell differentiation Cholesteatoma Extracellular vesicles Fibroblasts Growth factors Health aspects Hearing loss Hearing protection MicroRNA MicroRNAs Pathogenesis Review Systematic review Tumor necrosis factor-TNF |
| title | Expression and Regulatory Mechanisms of MicroRNA in Cholesteatoma: A Systematic Review |
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