Models in Pancreatic Neuroendocrine Neoplasms: Current Perspectives and Future Directions
Pancreatic neuroendocrine neoplasms (pNENs) are a heterogeneous group of tumors derived from multiple neuroendocrine origin cell subtypes. Incidence rates for pNENs have steadily risen over the last decade, and outcomes continue to vary widely due to inability to properly screen. These tumors encomp...
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Veröffentlicht in: | Cancers 2023-07, Vol.15 (15), p.3756 |
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description | Pancreatic neuroendocrine neoplasms (pNENs) are a heterogeneous group of tumors derived from multiple neuroendocrine origin cell subtypes. Incidence rates for pNENs have steadily risen over the last decade, and outcomes continue to vary widely due to inability to properly screen. These tumors encompass a wide range of functional and non-functional subtypes, with their rarity and slow growth making therapeutic development difficult as most clinically used therapeutics are derived from retrospective analyses. Improved molecular understanding of these cancers has increased our knowledge of the tumor biology for pNENs. Despite these advances in our understanding of pNENs, there remains a dearth of models for further investigation. In this review, we will cover the current field of pNEN models, which include established cell lines, animal models such as mice and zebrafish, and three-dimensional (3D) cell models, and compare their uses in modeling various disease aspects. While no study model is a complete representation of pNEN biology, each has advantages which allow for new scientific understanding of these rare tumors. Future efforts and advancements in technology will continue to create new options in modeling these cancers. |
doi_str_mv | 10.3390/cancers15153756 |
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Incidence rates for pNENs have steadily risen over the last decade, and outcomes continue to vary widely due to inability to properly screen. These tumors encompass a wide range of functional and non-functional subtypes, with their rarity and slow growth making therapeutic development difficult as most clinically used therapeutics are derived from retrospective analyses. Improved molecular understanding of these cancers has increased our knowledge of the tumor biology for pNENs. Despite these advances in our understanding of pNENs, there remains a dearth of models for further investigation. In this review, we will cover the current field of pNEN models, which include established cell lines, animal models such as mice and zebrafish, and three-dimensional (3D) cell models, and compare their uses in modeling various disease aspects. While no study model is a complete representation of pNEN biology, each has advantages which allow for new scientific understanding of these rare tumors. Future efforts and advancements in technology will continue to create new options in modeling these cancers.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers15153756</identifier><identifier>PMID: 37568572</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animal models ; Cancer ; Cell culture ; Cell cycle ; Danio rerio ; Diabetes ; DNA damage ; Genes ; Homeopathy ; Kinases ; Materia medica and therapeutics ; Metastasis ; Mutation ; Neuroendocrine tumors ; Oncology, Experimental ; Pancreas ; Patients ; Phase transitions ; Proteins ; Review ; Surveillance ; Therapeutics ; Tumorigenesis ; Tumors</subject><ispartof>Cancers, 2023-07, Vol.15 (15), p.3756</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c443t-e6427312a909bd73fc8f84f978985b318bd5caaad05ec8e66b07eaa562d29ccb3</cites><orcidid>0000-0003-4099-6642 ; 0000-0002-7538-9431</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416968/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416968/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37568572$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Forsythe, Steven D</creatorcontrib><creatorcontrib>Pu, Tracey</creatorcontrib><creatorcontrib>Andrews, Stephen G</creatorcontrib><creatorcontrib>Madigan, James P</creatorcontrib><creatorcontrib>Sadowski, Samira M</creatorcontrib><title>Models in Pancreatic Neuroendocrine Neoplasms: Current Perspectives and Future Directions</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>Pancreatic neuroendocrine neoplasms (pNENs) are a heterogeneous group of tumors derived from multiple neuroendocrine origin cell subtypes. Incidence rates for pNENs have steadily risen over the last decade, and outcomes continue to vary widely due to inability to properly screen. These tumors encompass a wide range of functional and non-functional subtypes, with their rarity and slow growth making therapeutic development difficult as most clinically used therapeutics are derived from retrospective analyses. Improved molecular understanding of these cancers has increased our knowledge of the tumor biology for pNENs. Despite these advances in our understanding of pNENs, there remains a dearth of models for further investigation. In this review, we will cover the current field of pNEN models, which include established cell lines, animal models such as mice and zebrafish, and three-dimensional (3D) cell models, and compare their uses in modeling various disease aspects. While no study model is a complete representation of pNEN biology, each has advantages which allow for new scientific understanding of these rare tumors. 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Pu, Tracey ; Andrews, Stephen G ; Madigan, James P ; Sadowski, Samira M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-e6427312a909bd73fc8f84f978985b318bd5caaad05ec8e66b07eaa562d29ccb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animal models</topic><topic>Cancer</topic><topic>Cell culture</topic><topic>Cell cycle</topic><topic>Danio rerio</topic><topic>Diabetes</topic><topic>DNA damage</topic><topic>Genes</topic><topic>Homeopathy</topic><topic>Kinases</topic><topic>Materia medica and therapeutics</topic><topic>Metastasis</topic><topic>Mutation</topic><topic>Neuroendocrine tumors</topic><topic>Oncology, Experimental</topic><topic>Pancreas</topic><topic>Patients</topic><topic>Phase transitions</topic><topic>Proteins</topic><topic>Review</topic><topic>Surveillance</topic><topic>Therapeutics</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Forsythe, Steven D</creatorcontrib><creatorcontrib>Pu, Tracey</creatorcontrib><creatorcontrib>Andrews, Stephen G</creatorcontrib><creatorcontrib>Madigan, James P</creatorcontrib><creatorcontrib>Sadowski, Samira M</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Forsythe, Steven D</au><au>Pu, Tracey</au><au>Andrews, Stephen G</au><au>Madigan, James P</au><au>Sadowski, Samira M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Models in Pancreatic Neuroendocrine Neoplasms: Current Perspectives and Future Directions</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2023-07-25</date><risdate>2023</risdate><volume>15</volume><issue>15</issue><spage>3756</spage><pages>3756-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Pancreatic neuroendocrine neoplasms (pNENs) are a heterogeneous group of tumors derived from multiple neuroendocrine origin cell subtypes. Incidence rates for pNENs have steadily risen over the last decade, and outcomes continue to vary widely due to inability to properly screen. These tumors encompass a wide range of functional and non-functional subtypes, with their rarity and slow growth making therapeutic development difficult as most clinically used therapeutics are derived from retrospective analyses. Improved molecular understanding of these cancers has increased our knowledge of the tumor biology for pNENs. Despite these advances in our understanding of pNENs, there remains a dearth of models for further investigation. In this review, we will cover the current field of pNEN models, which include established cell lines, animal models such as mice and zebrafish, and three-dimensional (3D) cell models, and compare their uses in modeling various disease aspects. While no study model is a complete representation of pNEN biology, each has advantages which allow for new scientific understanding of these rare tumors. Future efforts and advancements in technology will continue to create new options in modeling these cancers.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37568572</pmid><doi>10.3390/cancers15153756</doi><orcidid>https://orcid.org/0000-0003-4099-6642</orcidid><orcidid>https://orcid.org/0000-0002-7538-9431</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Animal models Cancer Cell culture Cell cycle Danio rerio Diabetes DNA damage Genes Homeopathy Kinases Materia medica and therapeutics Metastasis Mutation Neuroendocrine tumors Oncology, Experimental Pancreas Patients Phase transitions Proteins Review Surveillance Therapeutics Tumorigenesis Tumors |
title | Models in Pancreatic Neuroendocrine Neoplasms: Current Perspectives and Future Directions |
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