Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender
Previous research reported an age‐related decline in brain norepinephrine transporter (NET) using (S, S)‐[11C]O‐methylreboxetine ([11C]MRB) as a radiotracer. Studies with the same tracer have been mixed in regard to differences related to body mass index (BMI). Here, we investigated potential age‐,...
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| Veröffentlicht in: | Synapse (New York, N.Y.) N.Y.), 2023-09, Vol.77 (5), p.e22279-n/a |
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| creator | Koohsari, Sheida Sadabad, Faranak Ebrahimian Pittman, Brian Gallezot, Jean‐Dominque Carson, Richard E. Dyck, Christopher H. Li, Chiang‐shan R. Potenza, Marc N. Matuskey, David |
| description | Previous research reported an age‐related decline in brain norepinephrine transporter (NET) using (S, S)‐[11C]O‐methylreboxetine ([11C]MRB) as a radiotracer. Studies with the same tracer have been mixed in regard to differences related to body mass index (BMI). Here, we investigated potential age‐, BMI‐, and gender‐related differences in brain NET availability using [11C]MRB, the most selective available radiotracer. Forty‐three healthy participants (20 females, 23 males; age range 18–49 years), including 12 individuals with normal/lean weight, 15 with overweight, and 16 with obesity were scanned with [11C]MRB using a positron emission tomography (PET) high‐resolution research tomograph (HRRT). We evaluated binding potential (BPND) in brain regions with high NET availability using multilinear reference tissue model 2 (MRTM2) with the occipital cortex as a reference region. Brain regions were delineated with a defined anatomic template applied to subjects' structural MR scans.
We found a negative association between age and NET availability in the locus coeruleus, raphe nucleus, and hypothalamus, with a 17%, 19%, and 14% decrease per decade, respectively, in each region. No gender or BMI relationships with NET availability were observed. Our findings suggest an age‐related decline, but no BMI‐ or gender‐related differences, in NET availability in healthy adults. |
| doi_str_mv | 10.1002/syn.22279 |
| format | Article |
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We found a negative association between age and NET availability in the locus coeruleus, raphe nucleus, and hypothalamus, with a 17%, 19%, and 14% decrease per decade, respectively, in each region. No gender or BMI relationships with NET availability were observed. Our findings suggest an age‐related decline, but no BMI‐ or gender‐related differences, in NET availability in healthy adults.</description><identifier>ISSN: 0887-4476</identifier><identifier>ISSN: 1098-2396</identifier><identifier>EISSN: 1098-2396</identifier><identifier>DOI: 10.1002/syn.22279</identifier><identifier>PMID: 37382240</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Adult ; Age ; Body Mass Index ; Body weight ; Brain - diagnostic imaging ; Brain - metabolism ; Brain research ; Catecholamines ; Female ; Gender ; Humans ; Hypothalamus ; Locus coeruleus ; Male ; Middle Aged ; Morpholines - metabolism ; MRB ; NET ; Norepinephrine ; Norepinephrine Plasma Membrane Transport Proteins - metabolism ; Norepinephrine transporter ; Occipital lobe ; Overweight ; Positron emission tomography ; Positron-Emission Tomography - methods ; Radioactive tracers ; Raphe nuclei ; Reboxetine - metabolism ; Young Adult</subject><ispartof>Synapse (New York, N.Y.), 2023-09, Vol.77 (5), p.e22279-n/a</ispartof><rights>2023 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4099-f60309285879168b7cf0146bc54cc5446acf25772a2fb39de71ab0e5ae2210313</citedby><cites>FETCH-LOGICAL-c4099-f60309285879168b7cf0146bc54cc5446acf25772a2fb39de71ab0e5ae2210313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fsyn.22279$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fsyn.22279$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37382240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koohsari, Sheida</creatorcontrib><creatorcontrib>Sadabad, Faranak Ebrahimian</creatorcontrib><creatorcontrib>Pittman, Brian</creatorcontrib><creatorcontrib>Gallezot, Jean‐Dominque</creatorcontrib><creatorcontrib>Carson, Richard E.</creatorcontrib><creatorcontrib>Dyck, Christopher H.</creatorcontrib><creatorcontrib>Li, Chiang‐shan R.</creatorcontrib><creatorcontrib>Potenza, Marc N.</creatorcontrib><creatorcontrib>Matuskey, David</creatorcontrib><title>Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender</title><title>Synapse (New York, N.Y.)</title><addtitle>Synapse</addtitle><description>Previous research reported an age‐related decline in brain norepinephrine transporter (NET) using (S, S)‐[11C]O‐methylreboxetine ([11C]MRB) as a radiotracer. Studies with the same tracer have been mixed in regard to differences related to body mass index (BMI). Here, we investigated potential age‐, BMI‐, and gender‐related differences in brain NET availability using [11C]MRB, the most selective available radiotracer. Forty‐three healthy participants (20 females, 23 males; age range 18–49 years), including 12 individuals with normal/lean weight, 15 with overweight, and 16 with obesity were scanned with [11C]MRB using a positron emission tomography (PET) high‐resolution research tomograph (HRRT). We evaluated binding potential (BPND) in brain regions with high NET availability using multilinear reference tissue model 2 (MRTM2) with the occipital cortex as a reference region. Brain regions were delineated with a defined anatomic template applied to subjects' structural MR scans.
We found a negative association between age and NET availability in the locus coeruleus, raphe nucleus, and hypothalamus, with a 17%, 19%, and 14% decrease per decade, respectively, in each region. No gender or BMI relationships with NET availability were observed. Our findings suggest an age‐related decline, but no BMI‐ or gender‐related differences, in NET availability in healthy adults.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Body Mass Index</subject><subject>Body weight</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Brain research</subject><subject>Catecholamines</subject><subject>Female</subject><subject>Gender</subject><subject>Humans</subject><subject>Hypothalamus</subject><subject>Locus coeruleus</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Morpholines - metabolism</subject><subject>MRB</subject><subject>NET</subject><subject>Norepinephrine</subject><subject>Norepinephrine Plasma Membrane Transport Proteins - metabolism</subject><subject>Norepinephrine transporter</subject><subject>Occipital lobe</subject><subject>Overweight</subject><subject>Positron emission tomography</subject><subject>Positron-Emission Tomography - methods</subject><subject>Radioactive tracers</subject><subject>Raphe nuclei</subject><subject>Reboxetine - metabolism</subject><subject>Young Adult</subject><issn>0887-4476</issn><issn>1098-2396</issn><issn>1098-2396</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9vEzEQxS1ERUPhwBdAK3EpUrcdz-76zwmVqtBKhUotHDhZ3s1s4mpjL3YSlG9fpykVIHGwPdb89PRmHmNvOBxzADxJG3-MiFI_YxMOWpVYafGcTUApWda1FPvsZUp3AFBxqF-w_UpWCrGGCbu5ocEuXfBp7sZUhL5wvli7dSjaaHPpQ6TReRrnMd_FMlqfxhCXFAvrp4Wd0VHx8cvl0cNvRn5K8RXb6-2Q6PXje8C-fzr_dnZRXl1_vjw7vSq7GrQuewEVaFSNkpoL1cquB16LtmvqLp9a2K7HRkq02LeVnpLktgVqLCHyPEh1wD7sdMdVu6BpRz67G8wY3cLGjQnWmb873s3NLKxN3gEXgouscPioEMPPFaWlWbjU0TBYT2GVDKqKo1YImNF3_6B3YRV9nm9LCc65araW3u-oLoaUIvVPbjiYbVQmR2Ueosrs2z_tP5G_s8nAyQ745Qba_F_J3P74upO8B9k_nQU</recordid><startdate>202309</startdate><enddate>202309</enddate><creator>Koohsari, Sheida</creator><creator>Sadabad, Faranak Ebrahimian</creator><creator>Pittman, Brian</creator><creator>Gallezot, Jean‐Dominque</creator><creator>Carson, Richard E.</creator><creator>Dyck, Christopher H.</creator><creator>Li, Chiang‐shan R.</creator><creator>Potenza, Marc N.</creator><creator>Matuskey, David</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202309</creationdate><title>Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender</title><author>Koohsari, Sheida ; Sadabad, Faranak Ebrahimian ; Pittman, Brian ; Gallezot, Jean‐Dominque ; Carson, Richard E. ; Dyck, Christopher H. ; Li, Chiang‐shan R. ; Potenza, Marc N. ; Matuskey, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4099-f60309285879168b7cf0146bc54cc5446acf25772a2fb39de71ab0e5ae2210313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Body Mass Index</topic><topic>Body weight</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>Brain research</topic><topic>Catecholamines</topic><topic>Female</topic><topic>Gender</topic><topic>Humans</topic><topic>Hypothalamus</topic><topic>Locus coeruleus</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Morpholines - metabolism</topic><topic>MRB</topic><topic>NET</topic><topic>Norepinephrine</topic><topic>Norepinephrine Plasma Membrane Transport Proteins - metabolism</topic><topic>Norepinephrine transporter</topic><topic>Occipital lobe</topic><topic>Overweight</topic><topic>Positron emission tomography</topic><topic>Positron-Emission Tomography - methods</topic><topic>Radioactive tracers</topic><topic>Raphe nuclei</topic><topic>Reboxetine - metabolism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koohsari, Sheida</creatorcontrib><creatorcontrib>Sadabad, Faranak Ebrahimian</creatorcontrib><creatorcontrib>Pittman, Brian</creatorcontrib><creatorcontrib>Gallezot, Jean‐Dominque</creatorcontrib><creatorcontrib>Carson, Richard E.</creatorcontrib><creatorcontrib>Dyck, Christopher H.</creatorcontrib><creatorcontrib>Li, Chiang‐shan R.</creatorcontrib><creatorcontrib>Potenza, Marc N.</creatorcontrib><creatorcontrib>Matuskey, David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Synapse (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koohsari, Sheida</au><au>Sadabad, Faranak Ebrahimian</au><au>Pittman, Brian</au><au>Gallezot, Jean‐Dominque</au><au>Carson, Richard E.</au><au>Dyck, Christopher H.</au><au>Li, Chiang‐shan R.</au><au>Potenza, Marc N.</au><au>Matuskey, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender</atitle><jtitle>Synapse (New York, N.Y.)</jtitle><addtitle>Synapse</addtitle><date>2023-09</date><risdate>2023</risdate><volume>77</volume><issue>5</issue><spage>e22279</spage><epage>n/a</epage><pages>e22279-n/a</pages><issn>0887-4476</issn><issn>1098-2396</issn><eissn>1098-2396</eissn><abstract>Previous research reported an age‐related decline in brain norepinephrine transporter (NET) using (S, S)‐[11C]O‐methylreboxetine ([11C]MRB) as a radiotracer. Studies with the same tracer have been mixed in regard to differences related to body mass index (BMI). Here, we investigated potential age‐, BMI‐, and gender‐related differences in brain NET availability using [11C]MRB, the most selective available radiotracer. Forty‐three healthy participants (20 females, 23 males; age range 18–49 years), including 12 individuals with normal/lean weight, 15 with overweight, and 16 with obesity were scanned with [11C]MRB using a positron emission tomography (PET) high‐resolution research tomograph (HRRT). We evaluated binding potential (BPND) in brain regions with high NET availability using multilinear reference tissue model 2 (MRTM2) with the occipital cortex as a reference region. Brain regions were delineated with a defined anatomic template applied to subjects' structural MR scans.
We found a negative association between age and NET availability in the locus coeruleus, raphe nucleus, and hypothalamus, with a 17%, 19%, and 14% decrease per decade, respectively, in each region. No gender or BMI relationships with NET availability were observed. Our findings suggest an age‐related decline, but no BMI‐ or gender‐related differences, in NET availability in healthy adults.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37382240</pmid><doi>10.1002/syn.22279</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Wiley Journals |
| subjects | Adolescent Adult Age Body Mass Index Body weight Brain - diagnostic imaging Brain - metabolism Brain research Catecholamines Female Gender Humans Hypothalamus Locus coeruleus Male Middle Aged Morpholines - metabolism MRB NET Norepinephrine Norepinephrine Plasma Membrane Transport Proteins - metabolism Norepinephrine transporter Occipital lobe Overweight Positron emission tomography Positron-Emission Tomography - methods Radioactive tracers Raphe nuclei Reboxetine - metabolism Young Adult |
| title | Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender |
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