N-3-pyridylmethyl-N'-p-nitrophenylurea ocular toxicity in man and rabbits
Ingestion of the rat poison N-3-pyridylmethyl-N'-p-nitrophenylurea (PNU) produced ocular toxicity in three humans and in an animal model, the Dutch Belted rabbit. The electroretinogram b wave was especially susceptible to the effects of the rodenticide, and the target tissue appeared to be the...
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| Veröffentlicht in: | British journal of ophthalmology 1988-08, Vol.72 (8), p.584-590 |
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| container_title | British journal of ophthalmology |
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| creator | Mindel, J S Kharlamb, A B Friedman, A H Karam, J H Stone, R D Siegel, I M |
| description | Ingestion of the rat poison N-3-pyridylmethyl-N'-p-nitrophenylurea (PNU) produced ocular toxicity in three humans and in an animal model, the Dutch Belted rabbit. The electroretinogram b wave was especially susceptible to the effects of the rodenticide, and the target tissue appeared to be the retinal pigment epithelium. Injection of PNU itself did not produce ocular toxicity. The poison had to be administered orally. Gentamicin administered orally with PNU prevented the ocular toxicity. Presumably this antibiotic killed those gastrointestinal bacteria responsible for PNU's metabolism into an ocular toxin. L-tryptophan, a known antidote for the lethal effects of PNU, was an antidote for the ocular toxicity when administered orally but not when administered parenterally. |
| doi_str_mv | 10.1136/bjo.72.8.584 |
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The electroretinogram b wave was especially susceptible to the effects of the rodenticide, and the target tissue appeared to be the retinal pigment epithelium. Injection of PNU itself did not produce ocular toxicity. The poison had to be administered orally. Gentamicin administered orally with PNU prevented the ocular toxicity. Presumably this antibiotic killed those gastrointestinal bacteria responsible for PNU's metabolism into an ocular toxin. L-tryptophan, a known antidote for the lethal effects of PNU, was an antidote for the ocular toxicity when administered orally but not when administered parenterally.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo.72.8.584</identifier><identifier>PMID: 3415952</identifier><identifier>CODEN: BJOPAL</identifier><language>eng</language><publisher>BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd</publisher><subject>Adolescent ; Adult ; Animals ; Biological and medical sciences ; Electroretinography ; Eye Diseases - chemically induced ; Eye Diseases - physiopathology ; Eye Diseases - prevention & control ; Female ; Gentamicins - therapeutic use ; Humans ; Hypotension, Orthostatic - chemically induced ; Male ; Medical sciences ; Pesticides, fertilizers and other agrochemicals toxicology ; Phenylurea Compounds - antagonists & inhibitors ; Phenylurea Compounds - poisoning ; Phenylurea Compounds - toxicity ; Photoreceptor Cells - physiopathology ; Rabbits ; Retina - pathology ; Rodenticides - poisoning ; Rodenticides - toxicity ; Toxicology ; Tryptophan - administration & dosage ; Tryptophan - therapeutic use</subject><ispartof>British journal of ophthalmology, 1988-08, Vol.72 (8), p.584-590</ispartof><rights>1988 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Aug 1988</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b4524-a30538aeb6c8fdb4095619d290dc7694f65bde1b6d62e04e2a7f47882f1b053a3</citedby><cites>FETCH-LOGICAL-b4524-a30538aeb6c8fdb4095619d290dc7694f65bde1b6d62e04e2a7f47882f1b053a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1041532/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1041532/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7734377$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3415952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mindel, J S</creatorcontrib><creatorcontrib>Kharlamb, A B</creatorcontrib><creatorcontrib>Friedman, A H</creatorcontrib><creatorcontrib>Karam, J H</creatorcontrib><creatorcontrib>Stone, R D</creatorcontrib><creatorcontrib>Siegel, I M</creatorcontrib><title>N-3-pyridylmethyl-N'-p-nitrophenylurea ocular toxicity in man and rabbits</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>Ingestion of the rat poison N-3-pyridylmethyl-N'-p-nitrophenylurea (PNU) produced ocular toxicity in three humans and in an animal model, the Dutch Belted rabbit. The electroretinogram b wave was especially susceptible to the effects of the rodenticide, and the target tissue appeared to be the retinal pigment epithelium. Injection of PNU itself did not produce ocular toxicity. The poison had to be administered orally. Gentamicin administered orally with PNU prevented the ocular toxicity. Presumably this antibiotic killed those gastrointestinal bacteria responsible for PNU's metabolism into an ocular toxin. L-tryptophan, a known antidote for the lethal effects of PNU, was an antidote for the ocular toxicity when administered orally but not when administered parenterally.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Electroretinography</subject><subject>Eye Diseases - chemically induced</subject><subject>Eye Diseases - physiopathology</subject><subject>Eye Diseases - prevention & control</subject><subject>Female</subject><subject>Gentamicins - therapeutic use</subject><subject>Humans</subject><subject>Hypotension, Orthostatic - chemically induced</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>Phenylurea Compounds - antagonists & inhibitors</subject><subject>Phenylurea Compounds - poisoning</subject><subject>Phenylurea Compounds - toxicity</subject><subject>Photoreceptor Cells - physiopathology</subject><subject>Rabbits</subject><subject>Retina - pathology</subject><subject>Rodenticides - poisoning</subject><subject>Rodenticides - toxicity</subject><subject>Toxicology</subject><subject>Tryptophan - administration & dosage</subject><subject>Tryptophan - therapeutic use</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc-L1DAcxYMo6zh68yoUlN2LGfM77UXYHV1dWUYR9RqSNnUytkk3aWX735t1hkE9eMmX8D7fx_vyAHiK0QpjKl6ZXVhJsipXvGT3wAIzUUKCZHUfLBBCEmIs8EPwKKVd_hKB5Qk4oQzzipMFuNpACoc5umbuejtu5w5uzuAAvRtjGLbWz90UrS5CPXU6FmO4dbUb58L5ote-0L4pojbGjekxeNDqLtknh7kEXy_fflm_h9cf312tz6-hYZwwqCnitNTWiLpsG8NQxQWuGlKhppaiYq3gprHYiEYQi5glWrZMliVpscmbmi7B673vMJneNrX1Y9SdGqLrdZxV0E79rXi3Vd_DT4VRPpqSbHB6MIjhZrJpVL1Lte067W2YksKcSJ7zZPD5P-AuTNHn4xSWEiHKxW-7l3uqjiGlaNtjFIzUXUEqF6QkUaXKBWX82Z_xj_Chkay_OOg61bpro_a1S0dMSspofpYA7jGXRnt7lHX8oYSkkqvNt7XinzC9QB8-qzeZP9vzpt_9P-Av2myz8Q</recordid><startdate>19880801</startdate><enddate>19880801</enddate><creator>Mindel, J S</creator><creator>Kharlamb, A B</creator><creator>Friedman, A H</creator><creator>Karam, J H</creator><creator>Stone, R D</creator><creator>Siegel, I M</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7U7</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>19880801</creationdate><title>N-3-pyridylmethyl-N'-p-nitrophenylurea ocular toxicity in man and rabbits</title><author>Mindel, J S ; Kharlamb, A B ; Friedman, A H ; Karam, J H ; Stone, R D ; Siegel, I M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b4524-a30538aeb6c8fdb4095619d290dc7694f65bde1b6d62e04e2a7f47882f1b053a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Electroretinography</topic><topic>Eye Diseases - chemically induced</topic><topic>Eye Diseases - physiopathology</topic><topic>Eye Diseases - prevention & control</topic><topic>Female</topic><topic>Gentamicins - therapeutic use</topic><topic>Humans</topic><topic>Hypotension, Orthostatic - chemically induced</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Phenylurea Compounds - antagonists & inhibitors</topic><topic>Phenylurea Compounds - poisoning</topic><topic>Phenylurea Compounds - toxicity</topic><topic>Photoreceptor Cells - physiopathology</topic><topic>Rabbits</topic><topic>Retina - pathology</topic><topic>Rodenticides - poisoning</topic><topic>Rodenticides - toxicity</topic><topic>Toxicology</topic><topic>Tryptophan - administration & dosage</topic><topic>Tryptophan - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mindel, J S</creatorcontrib><creatorcontrib>Kharlamb, A B</creatorcontrib><creatorcontrib>Friedman, A H</creatorcontrib><creatorcontrib>Karam, J H</creatorcontrib><creatorcontrib>Stone, R D</creatorcontrib><creatorcontrib>Siegel, I M</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mindel, J S</au><au>Kharlamb, A B</au><au>Friedman, A H</au><au>Karam, J H</au><au>Stone, R D</au><au>Siegel, I M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N-3-pyridylmethyl-N'-p-nitrophenylurea ocular toxicity in man and rabbits</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>1988-08-01</date><risdate>1988</risdate><volume>72</volume><issue>8</issue><spage>584</spage><epage>590</epage><pages>584-590</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><coden>BJOPAL</coden><abstract>Ingestion of the rat poison N-3-pyridylmethyl-N'-p-nitrophenylurea (PNU) produced ocular toxicity in three humans and in an animal model, the Dutch Belted rabbit. The electroretinogram b wave was especially susceptible to the effects of the rodenticide, and the target tissue appeared to be the retinal pigment epithelium. Injection of PNU itself did not produce ocular toxicity. The poison had to be administered orally. Gentamicin administered orally with PNU prevented the ocular toxicity. Presumably this antibiotic killed those gastrointestinal bacteria responsible for PNU's metabolism into an ocular toxin. L-tryptophan, a known antidote for the lethal effects of PNU, was an antidote for the ocular toxicity when administered orally but not when administered parenterally.</abstract><cop>BMA House, Tavistock Square, London, WC1H 9JR</cop><pub>BMJ Publishing Group Ltd</pub><pmid>3415952</pmid><doi>10.1136/bjo.72.8.584</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of ophthalmology, 1988-08, Vol.72 (8), p.584-590 |
| issn | 0007-1161 1468-2079 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Adult Animals Biological and medical sciences Electroretinography Eye Diseases - chemically induced Eye Diseases - physiopathology Eye Diseases - prevention & control Female Gentamicins - therapeutic use Humans Hypotension, Orthostatic - chemically induced Male Medical sciences Pesticides, fertilizers and other agrochemicals toxicology Phenylurea Compounds - antagonists & inhibitors Phenylurea Compounds - poisoning Phenylurea Compounds - toxicity Photoreceptor Cells - physiopathology Rabbits Retina - pathology Rodenticides - poisoning Rodenticides - toxicity Toxicology Tryptophan - administration & dosage Tryptophan - therapeutic use |
| title | N-3-pyridylmethyl-N'-p-nitrophenylurea ocular toxicity in man and rabbits |
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