Treatment of cytomegalovirus retinitis with ganciclovir (9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (BW B759U)
Six patients (11 eyes) with virologically confirmed cytomegalovirus (CMV) retinitis involving the posterior pole of the eye were treated with a new drug, ganciclovir. Treatment with intravenous ganciclovir consistently halted progression of retinitis and produced improvement in measures of visual fu...
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| Veröffentlicht in: | British journal of ophthalmology 1988-07, Vol.72 (7), p.525-529 |
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| container_title | British journal of ophthalmology |
| container_volume | 72 |
| creator | Orellana, J Teich, S A Winterkorn, J S Mathur-Wagh, U Handwerger, S Schlamm, H Malamud, S C Yancovitz, S R Cederberg, D M Mildvan, D S |
| description | Six patients (11 eyes) with virologically confirmed cytomegalovirus (CMV) retinitis involving the posterior pole of the eye were treated with a new drug, ganciclovir. Treatment with intravenous ganciclovir consistently halted progression of retinitis and produced improvement in measures of visual function. However, within three weeks after cessation of therapy renewed CMV activity and worsening of visual function were observed in most cases. Maintenance therapy with ganciclovir extended the period of remission from CMV retinitis. |
| doi_str_mv | 10.1136/bjo.72.7.525 |
| format | Article |
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Treatment with intravenous ganciclovir consistently halted progression of retinitis and produced improvement in measures of visual function. However, within three weeks after cessation of therapy renewed CMV activity and worsening of visual function were observed in most cases. Maintenance therapy with ganciclovir extended the period of remission from CMV retinitis.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo.72.7.525</identifier><identifier>PMID: 2843219</identifier><identifier>CODEN: BJOPAL</identifier><language>eng</language><publisher>BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd</publisher><subject>Acquired Immunodeficiency Syndrome - complications ; Acyclovir - adverse effects ; Acyclovir - analogs & derivatives ; Acyclovir - therapeutic use ; Adult ; Antiviral Agents - adverse effects ; Antiviral Agents - therapeutic use ; Biological and medical sciences ; Cytomegalovirus Infections - complications ; Cytomegalovirus Infections - drug therapy ; Eye ; Female ; Fundus Oculi ; Ganciclovir ; Humans ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Retinitis - complications ; Retinitis - drug therapy ; Visual Acuity</subject><ispartof>British journal of ophthalmology, 1988-07, Vol.72 (7), p.525-529</ispartof><rights>1988 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Jul 1988</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b4525-be99aaa51f7cd7c372deefad1086996a2f4197ce1c5a981d7964458925b6527c3</citedby><cites>FETCH-LOGICAL-b4525-be99aaa51f7cd7c372deefad1086996a2f4197ce1c5a981d7964458925b6527c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1041518/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1041518/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7701384$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2843219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Orellana, J</creatorcontrib><creatorcontrib>Teich, S A</creatorcontrib><creatorcontrib>Winterkorn, J S</creatorcontrib><creatorcontrib>Mathur-Wagh, U</creatorcontrib><creatorcontrib>Handwerger, S</creatorcontrib><creatorcontrib>Schlamm, H</creatorcontrib><creatorcontrib>Malamud, S C</creatorcontrib><creatorcontrib>Yancovitz, S R</creatorcontrib><creatorcontrib>Cederberg, D M</creatorcontrib><creatorcontrib>Mildvan, D S</creatorcontrib><title>Treatment of cytomegalovirus retinitis with ganciclovir (9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (BW B759U)</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>Six patients (11 eyes) with virologically confirmed cytomegalovirus (CMV) retinitis involving the posterior pole of the eye were treated with a new drug, ganciclovir. Treatment with intravenous ganciclovir consistently halted progression of retinitis and produced improvement in measures of visual function. However, within three weeks after cessation of therapy renewed CMV activity and worsening of visual function were observed in most cases. Maintenance therapy with ganciclovir extended the period of remission from CMV retinitis.</description><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>Acyclovir - adverse effects</subject><subject>Acyclovir - analogs & derivatives</subject><subject>Acyclovir - therapeutic use</subject><subject>Adult</subject><subject>Antiviral Agents - adverse effects</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cytomegalovirus Infections - complications</subject><subject>Cytomegalovirus Infections - drug therapy</subject><subject>Eye</subject><subject>Female</subject><subject>Fundus Oculi</subject><subject>Ganciclovir</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Retinitis - complications</subject><subject>Retinitis - drug therapy</subject><subject>Visual Acuity</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kdGL1DAQxoMo57r65qsQUHQP7JpJm6Z5EbxFT2FRH-5UEAlpmu5mbZszac_tf2_OLYv64NNk-H6ZmY8PoYdAlgBp_qLcuSWnS75klN1CM8jyIqGEi9toRgjhCUAOd9G9EHaxpTnwE3RCiyylIGZof-GN6lvT9djVWI-9a81GNe7a-iFgb3rb2d4G_NP2W7xRnbb6t4gXIvlKk-1YebcfE0gW07M1_XZsTnEsx-4b3gyqs53Bi7PP-IwzcXl6H92pVRPMg6nO0eWb1xert8n6w_m71at1UmbRT1IaIZRSDGquK65TTitjalUBKXIhckXrDATXBjRTooCKizzLWCEoK3NG44c5enmYezWUral0dOpVI6-8bZUfpVNW_q10dis37loCyYBBEQc8nQZ492MwoZetDdo0jeqMG4KMUJ4WBY_g43_AnRt8F81J4JwQoITSSD0_UNq7ELypj6cAkTd5ypin5FRyGf1H_NGf5x_hKcCoP5l0FbRqan8TUThicS-kEZ2j5IDZ0Jv9UVb-u8x5ypl8_2kl03X25RyyjxIi_-zAl-3u_wf-AlQGxMI</recordid><startdate>19880701</startdate><enddate>19880701</enddate><creator>Orellana, J</creator><creator>Teich, S A</creator><creator>Winterkorn, J S</creator><creator>Mathur-Wagh, U</creator><creator>Handwerger, S</creator><creator>Schlamm, H</creator><creator>Malamud, S C</creator><creator>Yancovitz, S R</creator><creator>Cederberg, D M</creator><creator>Mildvan, D S</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7U9</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>19880701</creationdate><title>Treatment of cytomegalovirus retinitis with ganciclovir (9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (BW B759U)</title><author>Orellana, J ; Teich, S A ; Winterkorn, J S ; Mathur-Wagh, U ; Handwerger, S ; Schlamm, H ; Malamud, S C ; Yancovitz, S R ; Cederberg, D M ; Mildvan, D S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b4525-be99aaa51f7cd7c372deefad1086996a2f4197ce1c5a981d7964458925b6527c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Acquired Immunodeficiency Syndrome - complications</topic><topic>Acyclovir - adverse effects</topic><topic>Acyclovir - analogs & derivatives</topic><topic>Acyclovir - therapeutic use</topic><topic>Adult</topic><topic>Antiviral Agents - adverse effects</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cytomegalovirus Infections - complications</topic><topic>Cytomegalovirus Infections - drug therapy</topic><topic>Eye</topic><topic>Female</topic><topic>Fundus Oculi</topic><topic>Ganciclovir</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Retinitis - complications</topic><topic>Retinitis - drug therapy</topic><topic>Visual Acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Orellana, J</creatorcontrib><creatorcontrib>Teich, S A</creatorcontrib><creatorcontrib>Winterkorn, J S</creatorcontrib><creatorcontrib>Mathur-Wagh, U</creatorcontrib><creatorcontrib>Handwerger, S</creatorcontrib><creatorcontrib>Schlamm, H</creatorcontrib><creatorcontrib>Malamud, S C</creatorcontrib><creatorcontrib>Yancovitz, S R</creatorcontrib><creatorcontrib>Cederberg, D M</creatorcontrib><creatorcontrib>Mildvan, D S</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Orellana, J</au><au>Teich, S A</au><au>Winterkorn, J S</au><au>Mathur-Wagh, U</au><au>Handwerger, S</au><au>Schlamm, H</au><au>Malamud, S C</au><au>Yancovitz, S R</au><au>Cederberg, D M</au><au>Mildvan, D S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of cytomegalovirus retinitis with ganciclovir (9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (BW B759U)</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>1988-07-01</date><risdate>1988</risdate><volume>72</volume><issue>7</issue><spage>525</spage><epage>529</epage><pages>525-529</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><coden>BJOPAL</coden><abstract>Six patients (11 eyes) with virologically confirmed cytomegalovirus (CMV) retinitis involving the posterior pole of the eye were treated with a new drug, ganciclovir. Treatment with intravenous ganciclovir consistently halted progression of retinitis and produced improvement in measures of visual function. However, within three weeks after cessation of therapy renewed CMV activity and worsening of visual function were observed in most cases. Maintenance therapy with ganciclovir extended the period of remission from CMV retinitis.</abstract><cop>BMA House, Tavistock Square, London, WC1H 9JR</cop><pub>BMJ Publishing Group Ltd</pub><pmid>2843219</pmid><doi>10.1136/bjo.72.7.525</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of ophthalmology, 1988-07, Vol.72 (7), p.525-529 |
| issn | 0007-1161 1468-2079 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acquired Immunodeficiency Syndrome - complications Acyclovir - adverse effects Acyclovir - analogs & derivatives Acyclovir - therapeutic use Adult Antiviral Agents - adverse effects Antiviral Agents - therapeutic use Biological and medical sciences Cytomegalovirus Infections - complications Cytomegalovirus Infections - drug therapy Eye Female Fundus Oculi Ganciclovir Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Retinitis - complications Retinitis - drug therapy Visual Acuity |
| title | Treatment of cytomegalovirus retinitis with ganciclovir (9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (BW B759U) |
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