The role of catalytic and regulatory domains of human PrimPol in DNA binding and synthesis

Abstract Human PrimPol possesses DNA primase and DNA polymerase activities and restarts stalled replication forks protecting cells against DNA damage in nuclei and mitochondria. The zinc-binding motif (ZnFn) of the C-terminal domain (CTD) of PrimPol is required for DNA primase activity but the mecha...

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Veröffentlicht in:	Nucleic acids research 2023-08, Vol.51 (14), p.7541-7551
Hauptverfasser:	Boldinova, Elizaveta O, Baranovskiy, Andrey G, Gagarinskaya, Diana I, Manukyan, Anna A, Makarova, Alena V, Tahirov, Tahir H
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis DNA - genetics DNA Primase - metabolism DNA Primers DNA Replication DNA-Directed DNA Polymerase - metabolism Humans Multifunctional Enzymes - chemistry Nucleic Acid Enzymes
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