Drug delivery through soft contact lenses
Clinical studies were conducted on 466 patients waiting for senile cataract surgery and receiving chloromycetin, gentamicin, or carbenicillin subconjunctivally and through New Sauflon 70 and New Sauflon 85 lenses. The aqueous drug levels were biologically estimated at various time intervals. Soft co...
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| Veröffentlicht in: | British journal of ophthalmology 1988-02, Vol.72 (2), p.150-154 |
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| container_title | British journal of ophthalmology |
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| creator | Jain, M. R. |
| description | Clinical studies were conducted on 466 patients waiting for senile cataract surgery and receiving chloromycetin, gentamicin, or carbenicillin subconjunctivally and through New Sauflon 70 and New Sauflon 85 lenses. The aqueous drug levels were biologically estimated at various time intervals. Soft contact lenses provided significantly higher drug penetration than subconjunctival therapy. Both modes of treatment provided therapeutically effective levels against most of the common ocular pathogens for varying intervals of 2 to 12 hours. |
| doi_str_mv | 10.1136/bjo.72.2.150 |
| format | Article |
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Both modes of treatment provided therapeutically effective levels against most of the common ocular pathogens for varying intervals of 2 to 12 hours.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo.72.2.150</identifier><identifier>PMID: 3349016</identifier><identifier>CODEN: BJOPAL</identifier><language>eng</language><publisher>BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd</publisher><subject>Anti-Bacterial Agents - administration & dosage ; Aqueous Humor - metabolism ; Biological and medical sciences ; Carbenicillin - administration & dosage ; Carbenicillin - pharmacokinetics ; Chloramphenicol - administration & dosage ; Chloramphenicol - pharmacokinetics ; Contact Lenses, Hydrophilic ; Eye ; Eye Diseases - drug therapy ; Gentamicins - administration & dosage ; Gentamicins - pharmacokinetics ; Humans ; Hydrogel, Polyethylene Glycol Dimethacrylate ; Injections ; Medical sciences ; Pharmacology. 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R.</creatorcontrib><title>Drug delivery through soft contact lenses</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>Clinical studies were conducted on 466 patients waiting for senile cataract surgery and receiving chloromycetin, gentamicin, or carbenicillin subconjunctivally and through New Sauflon 70 and New Sauflon 85 lenses. The aqueous drug levels were biologically estimated at various time intervals. Soft contact lenses provided significantly higher drug penetration than subconjunctival therapy. Both modes of treatment provided therapeutically effective levels against most of the common ocular pathogens for varying intervals of 2 to 12 hours.</description><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Aqueous Humor - metabolism</subject><subject>Biological and medical sciences</subject><subject>Carbenicillin - administration & dosage</subject><subject>Carbenicillin - pharmacokinetics</subject><subject>Chloramphenicol - administration & dosage</subject><subject>Chloramphenicol - pharmacokinetics</subject><subject>Contact Lenses, Hydrophilic</subject><subject>Eye</subject><subject>Eye Diseases - drug therapy</subject><subject>Gentamicins - administration & dosage</subject><subject>Gentamicins - pharmacokinetics</subject><subject>Humans</subject><subject>Hydrogel, Polyethylene Glycol Dimethacrylate</subject><subject>Injections</subject><subject>Medical sciences</subject><subject>Pharmacology. 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R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b535t-2c0254ab183237742fdfa889381dcba9262a8492306fafefe93e256f52f189473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Aqueous Humor - metabolism</topic><topic>Biological and medical sciences</topic><topic>Carbenicillin - administration & dosage</topic><topic>Carbenicillin - pharmacokinetics</topic><topic>Chloramphenicol - administration & dosage</topic><topic>Chloramphenicol - pharmacokinetics</topic><topic>Contact Lenses, Hydrophilic</topic><topic>Eye</topic><topic>Eye Diseases - drug therapy</topic><topic>Gentamicins - administration & dosage</topic><topic>Gentamicins - pharmacokinetics</topic><topic>Humans</topic><topic>Hydrogel, Polyethylene Glycol Dimethacrylate</topic><topic>Injections</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Polyethylene Glycols - analysis</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jain, M. 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R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drug delivery through soft contact lenses</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>1988-02-01</date><risdate>1988</risdate><volume>72</volume><issue>2</issue><spage>150</spage><epage>154</epage><pages>150-154</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><coden>BJOPAL</coden><abstract>Clinical studies were conducted on 466 patients waiting for senile cataract surgery and receiving chloromycetin, gentamicin, or carbenicillin subconjunctivally and through New Sauflon 70 and New Sauflon 85 lenses. The aqueous drug levels were biologically estimated at various time intervals. Soft contact lenses provided significantly higher drug penetration than subconjunctival therapy. 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| fulltext | fulltext |
| identifier | ISSN: 0007-1161 |
| ispartof | British journal of ophthalmology, 1988-02, Vol.72 (2), p.150-154 |
| issn | 0007-1161 1468-2079 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1041390 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Anti-Bacterial Agents - administration & dosage Aqueous Humor - metabolism Biological and medical sciences Carbenicillin - administration & dosage Carbenicillin - pharmacokinetics Chloramphenicol - administration & dosage Chloramphenicol - pharmacokinetics Contact Lenses, Hydrophilic Eye Eye Diseases - drug therapy Gentamicins - administration & dosage Gentamicins - pharmacokinetics Humans Hydrogel, Polyethylene Glycol Dimethacrylate Injections Medical sciences Pharmacology. Drug treatments Polyethylene Glycols - analysis Time Factors |
| title | Drug delivery through soft contact lenses |
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