Morphology and Biochemistry of Ovulation
The process of ovulation involves multiple and iterrelated genetic, biochemical, and morphological events: cessation of the proliferation of granulosa cells, resumption of oocyte meiosis, expansion of cumulus cell-oocyte complexes, digestion of the follicle wall, and extrusion of the metaphase-II oo...
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| Veröffentlicht in: | Revista Brasileira de ginecologia e obstetrícia 2021-06, Vol.43 (6), p.480-486 |
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| container_title | Revista Brasileira de ginecologia e obstetrícia |
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| creator | Medeiros, Sebastião Freitas de Barbosa, Bruna Barcelo Medeiros, Matheus Antonio Souto de Yamamoto, Márcia Marly Winck |
| description | The process of ovulation involves multiple and iterrelated genetic, biochemical, and morphological events: cessation of the proliferation of granulosa cells, resumption of oocyte meiosis, expansion of cumulus cell-oocyte complexes, digestion of the follicle wall, and extrusion of the metaphase-II oocyte. The present narrative review examines these interrelated steps in detail. The combined or isolated roles of the follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are highlighted. Genes indiced by the FSH genes are relevant in the cumulus expansion, and LH-induced genes are critical for the resumption of meiosis and digestion of the follicle wall. A non-human model for follicle-wall digestion and oocyte release was provided. |
| doi_str_mv | 10.1055/s-0041-1731379 |
| format | Article |
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The present narrative review examines these interrelated steps in detail. The combined or isolated roles of the follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are highlighted. Genes indiced by the FSH genes are relevant in the cumulus expansion, and LH-induced genes are critical for the resumption of meiosis and digestion of the follicle wall. A non-human model for follicle-wall digestion and oocyte release was provided.</description><identifier>ISSN: 0100-7203</identifier><identifier>EISSN: 1806-9339</identifier><identifier>DOI: 10.1055/s-0041-1731379</identifier><identifier>PMID: 34318473</identifier><language>eng</language><publisher>Brazil: Thieme Revinter Publicações Ltda</publisher><subject>Animals ; Cumulus Cells - physiology ; Female ; Follicle Stimulating Hormone - genetics ; Follicle Stimulating Hormone - physiology ; Granulosa Cells - physiology ; Humans ; Luteinizing Hormone - genetics ; Luteinizing Hormone - physiology ; Meiosis - genetics ; Meiosis - physiology ; Models, Animal ; Oocytes - growth & development ; Ovarian Follicle - growth & development ; Ovulation - genetics ; Ovulation - physiology ; Review ; Signal Transduction</subject><ispartof>Revista Brasileira de ginecologia e obstetrícia, 2021-06, Vol.43 (6), p.480-486</ispartof><rights>Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).</rights><rights>Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. 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The present narrative review examines these interrelated steps in detail. The combined or isolated roles of the follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are highlighted. Genes indiced by the FSH genes are relevant in the cumulus expansion, and LH-induced genes are critical for the resumption of meiosis and digestion of the follicle wall. A non-human model for follicle-wall digestion and oocyte release was provided.</description><subject>Animals</subject><subject>Cumulus Cells - physiology</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - genetics</subject><subject>Follicle Stimulating Hormone - physiology</subject><subject>Granulosa Cells - physiology</subject><subject>Humans</subject><subject>Luteinizing Hormone - genetics</subject><subject>Luteinizing Hormone - physiology</subject><subject>Meiosis - genetics</subject><subject>Meiosis - physiology</subject><subject>Models, Animal</subject><subject>Oocytes - growth & development</subject><subject>Ovarian Follicle - growth & development</subject><subject>Ovulation - genetics</subject><subject>Ovulation - physiology</subject><subject>Review</subject><subject>Signal Transduction</subject><issn>0100-7203</issn><issn>1806-9339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM1PAjEQxRujEUSvHs0euSzObNttezJK_EowXPTclNKFNcsW210S_nuWgERPc5g3b977EXKLMELg_D6mAAxTFBSpUGekjxLyVFGqzkkfECAVGdAeuYrxGyATVLJL0qOMomSC9snww4f10ld-sU1MPU-eSm-XblXGJmwTXyTTTVuZpvT1NbkoTBXdzXEOyNfL8-f4LZ1MX9_Hj5PUUo5Nirk1zKGUmHMrYY4Fs8iMxC4FQzMDVghj0OWZVZTPMhRWFoYDVSAyBEEH5OHgu25nKze3rm6CqfQ6lCsTttqbUv_f1OVSL_xGY8cBUcnOYXh0CP6ndbHRXR3rqsrUzrdRZ5xzlUspVScdHaQ2-BiDK05_EPSer456z1cf-XYHd3_TneS_QOkOX050kA</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Medeiros, Sebastião Freitas de</creator><creator>Barbosa, Bruna Barcelo</creator><creator>Medeiros, Matheus Antonio Souto de</creator><creator>Yamamoto, Márcia Marly Winck</creator><general>Thieme Revinter Publicações Ltda</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4845-4226</orcidid><orcidid>https://orcid.org/0000-0003-4218-6766</orcidid><orcidid>https://orcid.org/0000-0003-4069-7490</orcidid><orcidid>https://orcid.org/0000-0003-1292-2515</orcidid></search><sort><creationdate>20210601</creationdate><title>Morphology and Biochemistry of Ovulation</title><author>Medeiros, Sebastião Freitas de ; Barbosa, Bruna Barcelo ; Medeiros, Matheus Antonio Souto de ; Yamamoto, Márcia Marly Winck</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-16ca4e188165c80d1f4c14a8120341ab04f7aa1e62c935b217c8fa50390721073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Cumulus Cells - physiology</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - genetics</topic><topic>Follicle Stimulating Hormone - physiology</topic><topic>Granulosa Cells - physiology</topic><topic>Humans</topic><topic>Luteinizing Hormone - genetics</topic><topic>Luteinizing Hormone - physiology</topic><topic>Meiosis - genetics</topic><topic>Meiosis - physiology</topic><topic>Models, Animal</topic><topic>Oocytes - growth & development</topic><topic>Ovarian Follicle - growth & development</topic><topic>Ovulation - genetics</topic><topic>Ovulation - physiology</topic><topic>Review</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Medeiros, Sebastião Freitas de</creatorcontrib><creatorcontrib>Barbosa, Bruna Barcelo</creatorcontrib><creatorcontrib>Medeiros, Matheus Antonio Souto de</creatorcontrib><creatorcontrib>Yamamoto, Márcia Marly Winck</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Revista Brasileira de ginecologia e obstetrícia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Medeiros, Sebastião Freitas de</au><au>Barbosa, Bruna Barcelo</au><au>Medeiros, Matheus Antonio Souto de</au><au>Yamamoto, Márcia Marly Winck</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morphology and Biochemistry of Ovulation</atitle><jtitle>Revista Brasileira de ginecologia e obstetrícia</jtitle><addtitle>Rev Bras Ginecol Obstet</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>43</volume><issue>6</issue><spage>480</spage><epage>486</epage><pages>480-486</pages><issn>0100-7203</issn><eissn>1806-9339</eissn><abstract>The process of ovulation involves multiple and iterrelated genetic, biochemical, and morphological events: cessation of the proliferation of granulosa cells, resumption of oocyte meiosis, expansion of cumulus cell-oocyte complexes, digestion of the follicle wall, and extrusion of the metaphase-II oocyte. 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| source | MEDLINE; DOAJ Directory of Open Access Journals; Thieme Connect Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Cumulus Cells - physiology Female Follicle Stimulating Hormone - genetics Follicle Stimulating Hormone - physiology Granulosa Cells - physiology Humans Luteinizing Hormone - genetics Luteinizing Hormone - physiology Meiosis - genetics Meiosis - physiology Models, Animal Oocytes - growth & development Ovarian Follicle - growth & development Ovulation - genetics Ovulation - physiology Review Signal Transduction |
| title | Morphology and Biochemistry of Ovulation |
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