Tear and serum antibody levels in ocular herpetic infection: diagnostic precision of secretory IgA

Tear and serum antibody levels in ocular herpetic infection: diagnostic precision of secretory IgA

A sensitive enzyme linked immunosorbent assay (ELISA) was developed to evaluate the potential of herpes simplex virus (HSV) specific antibodies in the diagnosis of herpetic eye infection. The presence of HSV specific secretory IgA (sIgA) in tears was found to be diagnostic of infection. However, ser...

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Veröffentlicht in:British journal of ophthalmology 1986-08, Vol.70 (8), p.584-588
Hauptverfasser: Fox, P D, Khaw, P T, McBride, B W, McGill, J I, Ward, K A
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies, Viral - analysis
Corneal Ulcer - immunology
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulin A - analysis
Immunoglobulin A, Secretory - analysis
Immunoglobulin G - analysis
Keratitis, Dendritic - diagnosis
Keratoconjunctivitis - immunology
Tears - immunology
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container_end_page 588
container_issue 8
container_start_page 584
container_title British journal of ophthalmology
container_volume 70
creator Fox, P D
Khaw, P T
McBride, B W
McGill, J I
Ward, K A
description A sensitive enzyme linked immunosorbent assay (ELISA) was developed to evaluate the potential of herpes simplex virus (HSV) specific antibodies in the diagnosis of herpetic eye infection. The presence of HSV specific secretory IgA (sIgA) in tears was found to be diagnostic of infection. However, serum and tear HSV specific IgG and IgA were not considered reliable indicators of active infection.
doi_str_mv 10.1136/bjo.70.8.584
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subjects Antibodies, Viral - analysis
Corneal Ulcer - immunology
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulin A - analysis
Immunoglobulin A, Secretory - analysis
Immunoglobulin G - analysis
Keratitis, Dendritic - diagnosis
Keratoconjunctivitis - immunology
Tears - immunology
title Tear and serum antibody levels in ocular herpetic infection: diagnostic precision of secretory IgA
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