Mutational and biophysical analyses reveal a TFIIIC binding region in the TFIIF-related Rpc53 subunit of RNA polymerase III

The TFIIF-like Rpc53/Rpc37 heterodimer of RNA polymerase (pol) III is involved in various stages of transcription. The C-terminal region of Rpc53 dimerizes with Rpc37 to anchor on the lobe domain of the pol III cleft. However, structural and functional features of the Rpc53 N-terminal region had not...

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Veröffentlicht in:	The Journal of biological chemistry 2023-07, Vol.299 (7), p.104859-104859, Article 104859
Hauptverfasser:	Shekhar, Arvind Chandra, Wu, Wen-Jin, Chen, Hung-Ta
Format:	Artikel
Sprache:	eng
Schlagworte:	Collection: Gene Regulation microscale thermophoresis Peptides - metabolism RNA polymerase III RNA Polymerase III - metabolism Rpc17 Rpc25 Rpc53 Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Tfc4 TFIIIC transcription Transcription Factors, TFIII - genetics Transcription, Genetic
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