HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53

Cataract is a leading ocular disease causing global blindness. The mechanism of cataractogenesis has not been well defined. Here, we demonstrate that the heat shock protein 90β (HSP90β) plays a fundamental role in suppressing cataractogenesis. HSP90β is the most dominant HSP in normal lens, and its...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-08, Vol.120 (31), p.e2221522120-e2221522120
Hauptverfasser:	Fu, Jia-Ling, Zheng, Shu-Yu, Wang, Yan, Hu, Xue-Bin, Xiao, Yuan, Wang, Jing-Miao, Zhang, Lan, Wang, Ling, Nie, Qian, Hou, Min, Bai, Yue-Yue, Gan, Yu-Wen, Liang, Xing-Miao, Xie, Liu-Liu, Li, David Wan-Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - genetics Animals Apoptosis BIM protein Biological Sciences Cataract - genetics Cataracts Cell differentiation Cytokinesis Danio rerio Endosomal Sorting Complexes Required for Transport - metabolism Epithelial cells Epithelium Eye diseases Gene regulation Heat shock proteins HSP90 Heat-Shock Proteins - metabolism Hsp90 protein Humans Lenses Mice Microphthalmia Multivesicular Bodies - metabolism p53 Protein Phenotypes Proteins Transcription factors Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Zebrafish Zebrafish - genetics Zebrafish - metabolism
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