Comparative study of antipyretic potency of extracts of morinda lucida leaves and fruits of capsicum frutescens in albino rats
leaves and fruits of are used locally in the management of fever in Nigeria. No scientific credence has been lent to this claim. To investigate the antipyretic effect and potency of aqueous extracts of leaves and fruits of in albino rats. Brewer's yeast was used to induce pyrexia. Thirty animal...
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| Veröffentlicht in: | African health sciences 2023-03, Vol.23 (1), p.213-7 |
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| creator | Adefolalu, Adedotun A Owoyele, Bamidele V Adesokan, Ayoade A |
| description | leaves and fruits of
are used locally in the management of fever in Nigeria. No scientific credence has been lent to this claim.
To investigate the antipyretic effect and potency of aqueous extracts of
leaves and fruits of
in albino rats.
Brewer's yeast was used to induce pyrexia. Thirty animals were divided into six groups. Group A was orally administered normal saline (103 mg/kg). Group B was served indomethacin (5 mg/kg), while groups C and D received aqueous extract of
at 100mg/kg and 200mg/kg, 17 hours post induction of pyrexia. Groups E and F were administered extract of
at the same doses. Rectal temperature of the animals was taken at 60-, 90- and 120-minutes post-treatment.
Both
and
produced significant reduction (p |
| doi_str_mv | 10.4314/ahs.v23i1.23 |
| format | Article |
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are used locally in the management of fever in Nigeria. No scientific credence has been lent to this claim.
To investigate the antipyretic effect and potency of aqueous extracts of
leaves and fruits of
in albino rats.
Brewer's yeast was used to induce pyrexia. Thirty animals were divided into six groups. Group A was orally administered normal saline (103 mg/kg). Group B was served indomethacin (5 mg/kg), while groups C and D received aqueous extract of
at 100mg/kg and 200mg/kg, 17 hours post induction of pyrexia. Groups E and F were administered extract of
at the same doses. Rectal temperature of the animals was taken at 60-, 90- and 120-minutes post-treatment.
Both
and
produced significant reduction (p<0.05) in rectal temperature after 120 minutes in the rats compared with animals in the control group. Also, the antipyretic activities of the two extracts at 100mg/kg and 200mg/kg were comparable to 5mg/kg of indomethacin, with apparent dose dependence in the antipyretic activities of both extracts.
leaves and fruits of
exhibit dose-dependent antipyretic activities.</description><identifier>ISSN: 1680-6905</identifier><identifier>EISSN: 1729-0503</identifier><identifier>DOI: 10.4314/ahs.v23i1.23</identifier><identifier>PMID: 37545963</identifier><language>eng</language><publisher>Uganda: Makerere Medical School</publisher><subject>Animals ; Antipyretics - pharmacology ; Capsicum ; Fever - drug therapy ; Fruit ; Indomethacin ; Morinda ; Plant Extracts - pharmacology ; Plant Leaves ; Rats</subject><ispartof>African health sciences, 2023-03, Vol.23 (1), p.213-7</ispartof><rights>2023 Adefolalu AA et al.</rights><rights>2023 Adefolalu AA et al. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398450/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398450/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37545963$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adefolalu, Adedotun A</creatorcontrib><creatorcontrib>Owoyele, Bamidele V</creatorcontrib><creatorcontrib>Adesokan, Ayoade A</creatorcontrib><title>Comparative study of antipyretic potency of extracts of morinda lucida leaves and fruits of capsicum frutescens in albino rats</title><title>African health sciences</title><addtitle>Afr Health Sci</addtitle><description>leaves and fruits of
are used locally in the management of fever in Nigeria. No scientific credence has been lent to this claim.
To investigate the antipyretic effect and potency of aqueous extracts of
leaves and fruits of
in albino rats.
Brewer's yeast was used to induce pyrexia. Thirty animals were divided into six groups. Group A was orally administered normal saline (103 mg/kg). Group B was served indomethacin (5 mg/kg), while groups C and D received aqueous extract of
at 100mg/kg and 200mg/kg, 17 hours post induction of pyrexia. Groups E and F were administered extract of
at the same doses. Rectal temperature of the animals was taken at 60-, 90- and 120-minutes post-treatment.
Both
and
produced significant reduction (p<0.05) in rectal temperature after 120 minutes in the rats compared with animals in the control group. Also, the antipyretic activities of the two extracts at 100mg/kg and 200mg/kg were comparable to 5mg/kg of indomethacin, with apparent dose dependence in the antipyretic activities of both extracts.
leaves and fruits of
exhibit dose-dependent antipyretic activities.</description><subject>Animals</subject><subject>Antipyretics - pharmacology</subject><subject>Capsicum</subject><subject>Fever - drug therapy</subject><subject>Fruit</subject><subject>Indomethacin</subject><subject>Morinda</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves</subject><subject>Rats</subject><issn>1680-6905</issn><issn>1729-0503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1v1DAQhi0Eou3CjTPykQNZ7Pgj8QmhFVCkSlzgbM06Y2qUxMF2Vt0Lvx1vt1RwmtHMM58vIa8420rB5Tu4zdtDKwLftuIJueRdaxqmmHhafd2zRhumLshVzj8ZazU3_Dm5EJ2SymhxSX7v4rRAghIOSHNZhyONnsJcwnJMWIKjSyw4u_sw3pUEruSTP8UU5gHouLpwMggHzLVwoD6t4cw4WHJw63QKFcwO50zDTGHchznSOjS_IM88jBlfPtgN-f7p47fddXPz9fOX3YebxgkmS7MXEoz2qJRue6YAGKoePHROa-Ocl6ITig_GDIORzHuucd95BQ49l73nYkPen_su637CoW5SLxntksIE6WgjBPt_Zg639kc8WM6E6WV954a8eeiQ4q8Vc7FTqBeNI8wY12zbXnZCylarir49oy7FnBP6xzmc2ZNmtmpm7zWzraj46393e4T_iiT-AGsFl8g</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Adefolalu, Adedotun A</creator><creator>Owoyele, Bamidele V</creator><creator>Adesokan, Ayoade A</creator><general>Makerere Medical School</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230301</creationdate><title>Comparative study of antipyretic potency of extracts of morinda lucida leaves and fruits of capsicum frutescens in albino rats</title><author>Adefolalu, Adedotun A ; Owoyele, Bamidele V ; Adesokan, Ayoade A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c304t-b34a96fe5562805aa0e58afa7c669ccf437351d99dd940ff16eb7f5acef148f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Antipyretics - pharmacology</topic><topic>Capsicum</topic><topic>Fever - drug therapy</topic><topic>Fruit</topic><topic>Indomethacin</topic><topic>Morinda</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Leaves</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adefolalu, Adedotun A</creatorcontrib><creatorcontrib>Owoyele, Bamidele V</creatorcontrib><creatorcontrib>Adesokan, Ayoade A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>African health sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adefolalu, Adedotun A</au><au>Owoyele, Bamidele V</au><au>Adesokan, Ayoade A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative study of antipyretic potency of extracts of morinda lucida leaves and fruits of capsicum frutescens in albino rats</atitle><jtitle>African health sciences</jtitle><addtitle>Afr Health Sci</addtitle><date>2023-03-01</date><risdate>2023</risdate><volume>23</volume><issue>1</issue><spage>213</spage><epage>7</epage><pages>213-7</pages><issn>1680-6905</issn><eissn>1729-0503</eissn><abstract>leaves and fruits of
are used locally in the management of fever in Nigeria. No scientific credence has been lent to this claim.
To investigate the antipyretic effect and potency of aqueous extracts of
leaves and fruits of
in albino rats.
Brewer's yeast was used to induce pyrexia. Thirty animals were divided into six groups. Group A was orally administered normal saline (103 mg/kg). Group B was served indomethacin (5 mg/kg), while groups C and D received aqueous extract of
at 100mg/kg and 200mg/kg, 17 hours post induction of pyrexia. Groups E and F were administered extract of
at the same doses. Rectal temperature of the animals was taken at 60-, 90- and 120-minutes post-treatment.
Both
and
produced significant reduction (p<0.05) in rectal temperature after 120 minutes in the rats compared with animals in the control group. Also, the antipyretic activities of the two extracts at 100mg/kg and 200mg/kg were comparable to 5mg/kg of indomethacin, with apparent dose dependence in the antipyretic activities of both extracts.
leaves and fruits of
exhibit dose-dependent antipyretic activities.</abstract><cop>Uganda</cop><pub>Makerere Medical School</pub><pmid>37545963</pmid><doi>10.4314/ahs.v23i1.23</doi><tpages>-205</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1680-6905 |
| ispartof | African health sciences, 2023-03, Vol.23 (1), p.213-7 |
| issn | 1680-6905 1729-0503 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10398450 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; African Journals Online (Open Access); Bioline International; PubMed Central |
| subjects | Animals Antipyretics - pharmacology Capsicum Fever - drug therapy Fruit Indomethacin Morinda Plant Extracts - pharmacology Plant Leaves Rats |
| title | Comparative study of antipyretic potency of extracts of morinda lucida leaves and fruits of capsicum frutescens in albino rats |
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