Surfactants or scaffolds? RNAs of varying lengths control the thermodynamic stability of condensates differently

Biomolecular condensates, thought to form via liquid-liquid phase separation of intracellular mixtures, are multicomponent systems that can include diverse types of proteins and RNAs. RNA is a critical modulator of RNA–protein condensate stability, as it induces an RNA concentration-dependent reentr...

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Veröffentlicht in:	Biophysical journal 2023-07, Vol.122 (14), p.2973-2987
Hauptverfasser:	Sanchez-Burgos, Ignacio, Herriott, Lara, Collepardo-Guevara, Rosana, Espinosa, Jorge R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomolecular Condensates Molecular Dynamics Simulation RNA Temperature Thermodynamics
Online-Zugang:	Volltext
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