Binding site plasticity regulation of the FimH catch-bond mechanism

The bacterial fimbrial adhesin FimH is a remarkable and well-studied catch-bond protein found at the tip of E. coli type 1 pili, which allows pathogenic strains involved in urinary tract infections to bind high-mannose glycans exposed on human epithelia. The catch-bond behavior of FimH, where the st...

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Veröffentlicht in:	Biophysical journal 2023-07, Vol.122 (13), p.2744-2756
Hauptverfasser:	Languin-Cattoën, Olivier, Sterpone, Fabio, Stirnemann, Guillaume
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Escherichia coli - chemistry Adhesins, Escherichia coli - metabolism Bacterial Adhesion - physiology Binding Sites Chemical Sciences Escherichia coli - metabolism Fimbriae Proteins - metabolism Humans or physical chemistry Protein Binding Theoretical and
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