A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection

Studies have demonstrated that at least 20% of individuals infected with SARS-CoV-2 remain asymptomatic 1 – 4 . Although most global efforts have focused on severe illness in COVID-19, examining asymptomatic infection provides a unique opportunity to consider early immunological features that promot...

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Veröffentlicht in:	Nature (London) 2023-08, Vol.620 (7972), p.128-136
Hauptverfasser:	Augusto, Danillo G., Murdolo, Lawton D., Chatzileontiadou, Demetra S. M., Sabatino, Joseph J., Yusufali, Tasneem, Peyser, Noah D., Butcher, Xochitl, Kizer, Kerry, Guthrie, Karoline, Murray, Victoria W., Pae, Vivian, Sarvadhavabhatla, Sannidhi, Beltran, Fiona, Gill, Gurjot S., Lynch, Kara L., Yun, Cassandra, Maguire, Colin T., Peluso, Michael J., Hoh, Rebecca, Henrich, Timothy J., Deeks, Steven G., Davidson, Michelle, Lu, Scott, Goldberg, Sarah A., Kelly, J. Daniel, Martin, Jeffrey N., Vierra-Green, Cynthia A., Spellman, Stephen R., Langton, David J., Dewar-Oldis, Michael J., Smith, Corey, Barnard, Peter J., Lee, Sulggi, Marcus, Gregory M., Olgin, Jeffrey E., Pletcher, Mark J., Maiers, Martin, Gras, Stephanie, Hollenbach, Jill A.
Format:	Artikel
Sprache:	eng
Schlagworte:	101/1 13/31 45/23 631/208/248/144 631/250/1619/554/1834 631/250/21 631/326/596/4130 692/699/255/2514 82/103 Alleles Antigens Asymptomatic Asymptomatic infection Asymptomatic Infections Cohort Studies Coronaviruses COVID-19 COVID-19 - genetics COVID-19 - immunology COVID-19 - physiopathology COVID-19 - virology COVID-19 vaccines Cross Reactions - immunology Cross-reactivity Crystal structure Disease Epitopes, T-Lymphocyte - immunology Genetics Genotyping Haplotypes Hepatitis Histocompatibility antigen HLA HLA-B Antigens - immunology Hospitalization Humanities and Social Sciences Humans Immunity Immunodominant Epitopes - immunology Immunological memory Immunology Infections Leukocytes Lymphocytes Lymphocytes T Memory cells multidisciplinary Pandemics Pathogenesis Peptides Peptides - immunology Phenotypes SARS-CoV-2 - immunology Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Signs and symptoms Smartphones Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - immunology T cell receptors T-Lymphocytes - immunology Viral diseases Viral infections
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