Prevalence, aetiology, vaccination coverage and spatio-temporal pattern among patients admitted with acute bacterial meningitis to the sentinel hospital surveillance network in Yemen, 2014–20, before and during the civil war

Prevalence, aetiology, vaccination coverage and spatio-temporal pattern among patients admitted with acute bacterial meningitis to the sentinel hospital surveillance network in Yemen, 2014–20, before and during the civil war

Abstract Background Acute bacterial meningitis (ABM) is a serious health issue in Yemen where civil war, which continues unabated, has crippled the healthcare system. We conducted a nationwide retrospective observational study in Yemeni sentinel hospitals to identify the prevalence, aetiology, vacci...

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Veröffentlicht in:International journal of epidemiology 2023-08, Vol.52 (4), p.1175-1186
Hauptverfasser: Al-Samhari, Galal A, Al-Mushiki, Gaber M, Tamrakar, Rashi, Lin, Yue-Dong, Al-Shaebi, Fadhl, Akroot, Mohammed A, Al-Nahari, Saddam A, Li, Guan-Jie, Tang, Xian-Yan
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container_title International journal of epidemiology
container_volume 52
creator Al-Samhari, Galal A
Al-Mushiki, Gaber M
Tamrakar, Rashi
Lin, Yue-Dong
Al-Shaebi, Fadhl
Akroot, Mohammed A
Al-Nahari, Saddam A
Li, Guan-Jie
Tang, Xian-Yan
description Abstract Background Acute bacterial meningitis (ABM) is a serious health issue in Yemen where civil war, which continues unabated, has crippled the healthcare system. We conducted a nationwide retrospective observational study in Yemeni sentinel hospitals to identify the prevalence, aetiology, vaccination coverage and spatio-temporal pattern of ABM in children aged
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We conducted a nationwide retrospective observational study in Yemeni sentinel hospitals to identify the prevalence, aetiology, vaccination coverage and spatio-temporal pattern of ABM in children aged &lt;5 years before and during the civil war, 2014–20. Methods Cerebrospinal fluid samples were collected from hospitalized children and were analysed macroscopically for appearance and microscopically by Gram stain and white blood cell count. Culture and latex agglutination tests were performed. Data on the prevalence of and vaccination coverage for ABM were obtained from the Ministry of Health. Joinpoint regression was used to assess the annual percent change (APC) of ABM prevalence and vaccination coverage. Pearson's correlation was used to evaluate the association between ABM prevalence and vaccination coverage. Results In total, 11 339 hospitalized children had suspected cases of ABM (prevalence, 40.07/100 000 of the whole Yemeni population) and 2.6% (293/11 339) of suspected ABM cases were confirmed (prevalence, 1.04/100 000 of the whole Yemeni population). The dominant pathogens were Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae type b (Hib). The civil war reduced the Hib and pneumococcal vaccination coverage (APC = –1.92), reaching its lowest (79.5%) in 2018. The prevalence of suspected ABM increased (APC = 3.46), reaching its maximum (6.08/100 000 of the whole Yemeni population) in 2019. The conflict inversely correlated with the ABM prevalence and vaccination coverage (Pearson correlation coefficient (r), –0.69 to –0.53). Ta'izz region, which was severely affected by the civil war, had the highest prevalence of suspected ABM (120.90/100 000 of the whole Yemeni population) and lowest vaccination coverage (60%). Conclusions The civil war had a negative impact on vaccination coverage and coincided with increasing prevalence of ABM in Yemen. Streptococcus pneumoniae is the dominant causative pathogen.</description><identifier>ISSN: 0300-5771</identifier><identifier>EISSN: 1464-3685</identifier><identifier>DOI: 10.1093/ije/dyad047</identifier><identifier>PMID: 37128839</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Infectious Diseases</subject><ispartof>International journal of epidemiology, 2023-08, Vol.52 (4), p.1175-1186</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of the International Epidemiological Association. 2023</rights><rights>The Author(s) 2023. Published by Oxford University Press on behalf of the International Epidemiological Association.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-79b4e2432076c738de65dc2636a29c762092bc9e265e560766266b2b4f64b4463</citedby><cites>FETCH-LOGICAL-c413t-79b4e2432076c738de65dc2636a29c762092bc9e265e560766266b2b4f64b4463</cites><orcidid>0000-0001-6842-7121 ; 0000-0003-4636-8532 ; 0000-0002-6290-5572</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37128839$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al-Samhari, Galal A</creatorcontrib><creatorcontrib>Al-Mushiki, Gaber M</creatorcontrib><creatorcontrib>Tamrakar, Rashi</creatorcontrib><creatorcontrib>Lin, Yue-Dong</creatorcontrib><creatorcontrib>Al-Shaebi, Fadhl</creatorcontrib><creatorcontrib>Akroot, Mohammed A</creatorcontrib><creatorcontrib>Al-Nahari, Saddam A</creatorcontrib><creatorcontrib>Li, Guan-Jie</creatorcontrib><creatorcontrib>Tang, Xian-Yan</creatorcontrib><title>Prevalence, aetiology, vaccination coverage and spatio-temporal pattern among patients admitted with acute bacterial meningitis to the sentinel hospital surveillance network in Yemen, 2014–20, before and during the civil war</title><title>International journal of epidemiology</title><addtitle>Int J Epidemiol</addtitle><description>Abstract Background Acute bacterial meningitis (ABM) is a serious health issue in Yemen where civil war, which continues unabated, has crippled the healthcare system. We conducted a nationwide retrospective observational study in Yemeni sentinel hospitals to identify the prevalence, aetiology, vaccination coverage and spatio-temporal pattern of ABM in children aged &lt;5 years before and during the civil war, 2014–20. Methods Cerebrospinal fluid samples were collected from hospitalized children and were analysed macroscopically for appearance and microscopically by Gram stain and white blood cell count. Culture and latex agglutination tests were performed. Data on the prevalence of and vaccination coverage for ABM were obtained from the Ministry of Health. Joinpoint regression was used to assess the annual percent change (APC) of ABM prevalence and vaccination coverage. Pearson's correlation was used to evaluate the association between ABM prevalence and vaccination coverage. Results In total, 11 339 hospitalized children had suspected cases of ABM (prevalence, 40.07/100 000 of the whole Yemeni population) and 2.6% (293/11 339) of suspected ABM cases were confirmed (prevalence, 1.04/100 000 of the whole Yemeni population). The dominant pathogens were Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae type b (Hib). The civil war reduced the Hib and pneumococcal vaccination coverage (APC = –1.92), reaching its lowest (79.5%) in 2018. The prevalence of suspected ABM increased (APC = 3.46), reaching its maximum (6.08/100 000 of the whole Yemeni population) in 2019. The conflict inversely correlated with the ABM prevalence and vaccination coverage (Pearson correlation coefficient (r), –0.69 to –0.53). Ta'izz region, which was severely affected by the civil war, had the highest prevalence of suspected ABM (120.90/100 000 of the whole Yemeni population) and lowest vaccination coverage (60%). Conclusions The civil war had a negative impact on vaccination coverage and coincided with increasing prevalence of ABM in Yemen. Streptococcus pneumoniae is the dominant causative pathogen.</description><subject>Infectious Diseases</subject><issn>0300-5771</issn><issn>1464-3685</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp9kruO1DAUhiMEYoeFih6dCiExYX2Lk1QrtOImrQQFFFSR45zJeEnsYDsZTcc78Ib7JHiYYQUNlXV8vvOfi_4se0rJK0pqfmFu8KLbq46I8l62okKKnMuquJ-tCCckL8qSnmWPQrghhAoh6ofZGS8pqyper7LbTx4XNaDVuAaF0bjB9fs1LEprY1WKLWi3oFc9grIdhOnwmUccJ-fVACmM6C2o0dn-EBm0MYDqRpMSHexM3ILSc0RolU6oSUUjWmN7E02A6CBuEUKqMhYH2LowmZiYMPsFzTCoNBpYjDvnv4Gx8BVT9RpYWub2x09G1tDixvnjdN3sk_BvRW0WM8BO-cfZg40aAj45vefZl7dvPl-9z68_vvtw9fo614LymJd1K5AJzkgpdcmrDmXRaSa5VKzWpWSkZq2ukckCC5kgyaRsWSs2UrRCSH6eXR51p7kdsdNpo3SgZvJmVH7fOGWafzPWbJveLQ0lvJaC0qTw4qTg3fcZQ2xGEzQeboBuDg2rSFVUJanLhL48otq7EDxu7vpQ0hxs0SRbNCdbJPrZ36PdsX98kIDnR8DN03-VfgG-fMgJ</recordid><startdate>20230802</startdate><enddate>20230802</enddate><creator>Al-Samhari, Galal A</creator><creator>Al-Mushiki, Gaber M</creator><creator>Tamrakar, Rashi</creator><creator>Lin, Yue-Dong</creator><creator>Al-Shaebi, Fadhl</creator><creator>Akroot, Mohammed A</creator><creator>Al-Nahari, Saddam A</creator><creator>Li, Guan-Jie</creator><creator>Tang, Xian-Yan</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6842-7121</orcidid><orcidid>https://orcid.org/0000-0003-4636-8532</orcidid><orcidid>https://orcid.org/0000-0002-6290-5572</orcidid></search><sort><creationdate>20230802</creationdate><title>Prevalence, aetiology, vaccination coverage and spatio-temporal pattern among patients admitted with acute bacterial meningitis to the sentinel hospital surveillance network in Yemen, 2014–20, before and during the civil war</title><author>Al-Samhari, Galal A ; Al-Mushiki, Gaber M ; Tamrakar, Rashi ; Lin, Yue-Dong ; Al-Shaebi, Fadhl ; Akroot, Mohammed A ; Al-Nahari, Saddam A ; Li, Guan-Jie ; Tang, Xian-Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-79b4e2432076c738de65dc2636a29c762092bc9e265e560766266b2b4f64b4463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Infectious Diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al-Samhari, Galal A</creatorcontrib><creatorcontrib>Al-Mushiki, Gaber M</creatorcontrib><creatorcontrib>Tamrakar, Rashi</creatorcontrib><creatorcontrib>Lin, Yue-Dong</creatorcontrib><creatorcontrib>Al-Shaebi, Fadhl</creatorcontrib><creatorcontrib>Akroot, Mohammed A</creatorcontrib><creatorcontrib>Al-Nahari, Saddam A</creatorcontrib><creatorcontrib>Li, Guan-Jie</creatorcontrib><creatorcontrib>Tang, Xian-Yan</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Samhari, Galal A</au><au>Al-Mushiki, Gaber M</au><au>Tamrakar, Rashi</au><au>Lin, Yue-Dong</au><au>Al-Shaebi, Fadhl</au><au>Akroot, Mohammed A</au><au>Al-Nahari, Saddam A</au><au>Li, Guan-Jie</au><au>Tang, Xian-Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence, aetiology, vaccination coverage and spatio-temporal pattern among patients admitted with acute bacterial meningitis to the sentinel hospital surveillance network in Yemen, 2014–20, before and during the civil war</atitle><jtitle>International journal of epidemiology</jtitle><addtitle>Int J Epidemiol</addtitle><date>2023-08-02</date><risdate>2023</risdate><volume>52</volume><issue>4</issue><spage>1175</spage><epage>1186</epage><pages>1175-1186</pages><issn>0300-5771</issn><eissn>1464-3685</eissn><abstract>Abstract Background Acute bacterial meningitis (ABM) is a serious health issue in Yemen where civil war, which continues unabated, has crippled the healthcare system. We conducted a nationwide retrospective observational study in Yemeni sentinel hospitals to identify the prevalence, aetiology, vaccination coverage and spatio-temporal pattern of ABM in children aged &lt;5 years before and during the civil war, 2014–20. Methods Cerebrospinal fluid samples were collected from hospitalized children and were analysed macroscopically for appearance and microscopically by Gram stain and white blood cell count. Culture and latex agglutination tests were performed. Data on the prevalence of and vaccination coverage for ABM were obtained from the Ministry of Health. Joinpoint regression was used to assess the annual percent change (APC) of ABM prevalence and vaccination coverage. Pearson's correlation was used to evaluate the association between ABM prevalence and vaccination coverage. Results In total, 11 339 hospitalized children had suspected cases of ABM (prevalence, 40.07/100 000 of the whole Yemeni population) and 2.6% (293/11 339) of suspected ABM cases were confirmed (prevalence, 1.04/100 000 of the whole Yemeni population). The dominant pathogens were Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae type b (Hib). The civil war reduced the Hib and pneumococcal vaccination coverage (APC = –1.92), reaching its lowest (79.5%) in 2018. The prevalence of suspected ABM increased (APC = 3.46), reaching its maximum (6.08/100 000 of the whole Yemeni population) in 2019. The conflict inversely correlated with the ABM prevalence and vaccination coverage (Pearson correlation coefficient (r), –0.69 to –0.53). Ta'izz region, which was severely affected by the civil war, had the highest prevalence of suspected ABM (120.90/100 000 of the whole Yemeni population) and lowest vaccination coverage (60%). Conclusions The civil war had a negative impact on vaccination coverage and coincided with increasing prevalence of ABM in Yemen. Streptococcus pneumoniae is the dominant causative pathogen.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>37128839</pmid><doi>10.1093/ije/dyad047</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-6842-7121</orcidid><orcidid>https://orcid.org/0000-0003-4636-8532</orcidid><orcidid>https://orcid.org/0000-0002-6290-5572</orcidid><oa>free_for_read</oa></addata></record>
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source Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
subjects Infectious Diseases
title Prevalence, aetiology, vaccination coverage and spatio-temporal pattern among patients admitted with acute bacterial meningitis to the sentinel hospital surveillance network in Yemen, 2014–20, before and during the civil war
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