Higher Improvement of Cardiac Function Following Myocardial Infarction using Menstrual Blood Stromal/Stem Cells (MenSCs) Suspended in Conditioned Medium versus Conditioned Medium Alone in Rat Model
To evaluate the efficiency of Menstrual blood Stromal/Stem Cells (MenSCs) administration in Myocardial Infarction (MI), the effects of MenSCs and their derived conditioned Medium (CM) on cardiac function in MI rat model was assessed. Animals were divided into four groups including sham group, MI gro...
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| Veröffentlicht in: | Avicenna journal of medical biotechnology 2023-07, Vol.15 (3), p.157-166 |
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| container_title | Avicenna journal of medical biotechnology |
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| creator | Manshori, Mahmood Kazemnejad, Somaieh Naderi, Nasim Shirazi, Abolfazl Arabian, Maedeh Eghtedar Doost, Marzieh Darzi, Maryam Montazeri, Samaneh Aboutaleb, Nahid Golshahi, Hannaneh |
| description | To evaluate the efficiency of Menstrual blood Stromal/Stem Cells (MenSCs) administration in Myocardial Infarction (MI), the effects of MenSCs and their derived conditioned Medium (CM) on cardiac function in MI rat model was assessed.
Animals were divided into four groups including sham group, MI group, MenSCs derived CM group (CM group), and MenSCs suspended in CM (MenSCs+CM) group. The injection of different groups was carried out 30
after ligation of left anterior descending coronary artery into the infarct border zone.
The results showed a significant reduction in scar size after injection of MenSCs+CM compared to MI group. Ejection fraction and fractional shortening of MenSCs+CM group were higher than CM and MI group at day 28. Administration of MenSCs+CM led to much more survival of cardiomyocytes, and prevention of meta-plastic development. Moreover, human mitochondrial transfer from MenSCs to cardiomyocytes was seen in group treated by MenSCs+CM. Indeed, MenSCs+CM treatment evoked nuclear factor-κB (NF-κB) down-regulation more than other treatments.
MenSCs+CM treatment could significantly ameliorate cardiac function by different mechanisms including inhibition of cartilaginous metaplasia, inhibition of NF-κB and mitochondrial transfer. |
| doi_str_mv | 10.18502/ajmb.v15i3.12924 |
| format | Article |
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Animals were divided into four groups including sham group, MI group, MenSCs derived CM group (CM group), and MenSCs suspended in CM (MenSCs+CM) group. The injection of different groups was carried out 30
after ligation of left anterior descending coronary artery into the infarct border zone.
The results showed a significant reduction in scar size after injection of MenSCs+CM compared to MI group. Ejection fraction and fractional shortening of MenSCs+CM group were higher than CM and MI group at day 28. Administration of MenSCs+CM led to much more survival of cardiomyocytes, and prevention of meta-plastic development. Moreover, human mitochondrial transfer from MenSCs to cardiomyocytes was seen in group treated by MenSCs+CM. Indeed, MenSCs+CM treatment evoked nuclear factor-κB (NF-κB) down-regulation more than other treatments.
MenSCs+CM treatment could significantly ameliorate cardiac function by different mechanisms including inhibition of cartilaginous metaplasia, inhibition of NF-κB and mitochondrial transfer.</description><identifier>ISSN: 2008-2835</identifier><identifier>EISSN: 2008-4625</identifier><identifier>DOI: 10.18502/ajmb.v15i3.12924</identifier><identifier>PMID: 37538240</identifier><language>eng</language><publisher>Iran: Avicenna Research Institute</publisher><subject>Original</subject><ispartof>Avicenna journal of medical biotechnology, 2023-07, Vol.15 (3), p.157-166</ispartof><rights>Copyright© 2023 Avicenna Research Institute.</rights><rights>Copyright© 2023 Avicenna Research Institute 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395459/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395459/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37538240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manshori, Mahmood</creatorcontrib><creatorcontrib>Kazemnejad, Somaieh</creatorcontrib><creatorcontrib>Naderi, Nasim</creatorcontrib><creatorcontrib>Shirazi, Abolfazl</creatorcontrib><creatorcontrib>Arabian, Maedeh</creatorcontrib><creatorcontrib>Eghtedar Doost, Marzieh</creatorcontrib><creatorcontrib>Darzi, Maryam</creatorcontrib><creatorcontrib>Montazeri, Samaneh</creatorcontrib><creatorcontrib>Aboutaleb, Nahid</creatorcontrib><creatorcontrib>Golshahi, Hannaneh</creatorcontrib><title>Higher Improvement of Cardiac Function Following Myocardial Infarction using Menstrual Blood Stromal/Stem Cells (MenSCs) Suspended in Conditioned Medium versus Conditioned Medium Alone in Rat Model</title><title>Avicenna journal of medical biotechnology</title><addtitle>Avicenna J Med Biotechnol</addtitle><description>To evaluate the efficiency of Menstrual blood Stromal/Stem Cells (MenSCs) administration in Myocardial Infarction (MI), the effects of MenSCs and their derived conditioned Medium (CM) on cardiac function in MI rat model was assessed.
Animals were divided into four groups including sham group, MI group, MenSCs derived CM group (CM group), and MenSCs suspended in CM (MenSCs+CM) group. The injection of different groups was carried out 30
after ligation of left anterior descending coronary artery into the infarct border zone.
The results showed a significant reduction in scar size after injection of MenSCs+CM compared to MI group. Ejection fraction and fractional shortening of MenSCs+CM group were higher than CM and MI group at day 28. Administration of MenSCs+CM led to much more survival of cardiomyocytes, and prevention of meta-plastic development. Moreover, human mitochondrial transfer from MenSCs to cardiomyocytes was seen in group treated by MenSCs+CM. Indeed, MenSCs+CM treatment evoked nuclear factor-κB (NF-κB) down-regulation more than other treatments.
MenSCs+CM treatment could significantly ameliorate cardiac function by different mechanisms including inhibition of cartilaginous metaplasia, inhibition of NF-κB and mitochondrial transfer.</description><subject>Original</subject><issn>2008-2835</issn><issn>2008-4625</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNptUstqGzEUHUpLE9J8QDdFy3RhR895rEo61IkhJhC3a6HR3HEUNJIrzbjkA_NfkcdOaKHaSJfzkDg6WfaZ4DkpBaaX6rFv5jsiDJsTWlH-LjulGJcznlPx_nimJRMn2XmMj3i_CiwE-5idsEKwknJ8mj3fmM0DBLTst8HvoAc3IN-hWoXWKI0Wo9OD8Q4tvLX-j3EbtHryekItWrpOhQM-xgkDF4cwJui79b5F6yH4XtnL9QA9qsHaiC4SZ13Hr2g9xi24FlpkHKq9a83eKI0raM3Yox2EOMb_IVc2TXvVvRrQyrdgP2UfOmUjnB_3s-zX4sfP-mZ2e3e9rK9uZ5rmBZ8R1jR5RxXWGlOcEgBgtNJcV2XRFUQpXpIGNGVNJ1po8oaVHDqhlCbAeNOxs-zbwXc7Nj20OqUVlJXbYHoVnqRXRv6LOPMgN34nCWaV4KJKDhdHh-B_jxAH2ZuoUzLKgR-jpCXPK4Y5KROVHKg6-BgDdG_3ECynCsh9BeRUATlVIGm-_P3AN8Xrh7MXOUazew</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Manshori, Mahmood</creator><creator>Kazemnejad, Somaieh</creator><creator>Naderi, Nasim</creator><creator>Shirazi, Abolfazl</creator><creator>Arabian, Maedeh</creator><creator>Eghtedar Doost, Marzieh</creator><creator>Darzi, Maryam</creator><creator>Montazeri, Samaneh</creator><creator>Aboutaleb, Nahid</creator><creator>Golshahi, Hannaneh</creator><general>Avicenna Research Institute</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202307</creationdate><title>Higher Improvement of Cardiac Function Following Myocardial Infarction using Menstrual Blood Stromal/Stem Cells (MenSCs) Suspended in Conditioned Medium versus Conditioned Medium Alone in Rat Model</title><author>Manshori, Mahmood ; Kazemnejad, Somaieh ; Naderi, Nasim ; Shirazi, Abolfazl ; Arabian, Maedeh ; Eghtedar Doost, Marzieh ; Darzi, Maryam ; Montazeri, Samaneh ; Aboutaleb, Nahid ; Golshahi, Hannaneh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2674-13bb6f2a0cc020382ee329c4c987f71aa481bec23bf5deb6b384ef5aac1e34bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Original</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manshori, Mahmood</creatorcontrib><creatorcontrib>Kazemnejad, Somaieh</creatorcontrib><creatorcontrib>Naderi, Nasim</creatorcontrib><creatorcontrib>Shirazi, Abolfazl</creatorcontrib><creatorcontrib>Arabian, Maedeh</creatorcontrib><creatorcontrib>Eghtedar Doost, Marzieh</creatorcontrib><creatorcontrib>Darzi, Maryam</creatorcontrib><creatorcontrib>Montazeri, Samaneh</creatorcontrib><creatorcontrib>Aboutaleb, Nahid</creatorcontrib><creatorcontrib>Golshahi, Hannaneh</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Avicenna journal of medical biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manshori, Mahmood</au><au>Kazemnejad, Somaieh</au><au>Naderi, Nasim</au><au>Shirazi, Abolfazl</au><au>Arabian, Maedeh</au><au>Eghtedar Doost, Marzieh</au><au>Darzi, Maryam</au><au>Montazeri, Samaneh</au><au>Aboutaleb, Nahid</au><au>Golshahi, Hannaneh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Higher Improvement of Cardiac Function Following Myocardial Infarction using Menstrual Blood Stromal/Stem Cells (MenSCs) Suspended in Conditioned Medium versus Conditioned Medium Alone in Rat Model</atitle><jtitle>Avicenna journal of medical biotechnology</jtitle><addtitle>Avicenna J Med Biotechnol</addtitle><date>2023-07</date><risdate>2023</risdate><volume>15</volume><issue>3</issue><spage>157</spage><epage>166</epage><pages>157-166</pages><issn>2008-2835</issn><eissn>2008-4625</eissn><abstract>To evaluate the efficiency of Menstrual blood Stromal/Stem Cells (MenSCs) administration in Myocardial Infarction (MI), the effects of MenSCs and their derived conditioned Medium (CM) on cardiac function in MI rat model was assessed.
Animals were divided into four groups including sham group, MI group, MenSCs derived CM group (CM group), and MenSCs suspended in CM (MenSCs+CM) group. The injection of different groups was carried out 30
after ligation of left anterior descending coronary artery into the infarct border zone.
The results showed a significant reduction in scar size after injection of MenSCs+CM compared to MI group. Ejection fraction and fractional shortening of MenSCs+CM group were higher than CM and MI group at day 28. Administration of MenSCs+CM led to much more survival of cardiomyocytes, and prevention of meta-plastic development. Moreover, human mitochondrial transfer from MenSCs to cardiomyocytes was seen in group treated by MenSCs+CM. Indeed, MenSCs+CM treatment evoked nuclear factor-κB (NF-κB) down-regulation more than other treatments.
MenSCs+CM treatment could significantly ameliorate cardiac function by different mechanisms including inhibition of cartilaginous metaplasia, inhibition of NF-κB and mitochondrial transfer.</abstract><cop>Iran</cop><pub>Avicenna Research Institute</pub><pmid>37538240</pmid><doi>10.18502/ajmb.v15i3.12924</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| title | Higher Improvement of Cardiac Function Following Myocardial Infarction using Menstrual Blood Stromal/Stem Cells (MenSCs) Suspended in Conditioned Medium versus Conditioned Medium Alone in Rat Model |
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