Characterization of cannabinoid receptors expressed in Ewing sarcoma TC-71 and A-673 cells as potential targets for anti-cancer drug development

Characterizing cannabinoid receptors (CBRs) expressed in Ewing sarcoma (EWS) cell lines as potential targets for anti-cancer drug development. CBR affinity and function were examined by competitive binding and G-protein activation, respectively. Cannabinoid-mediated cytotoxicity and cell viability w...

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Veröffentlicht in:	Life sciences (1973) 2021-11, Vol.285, p.119993-119993, Article 119993
Hauptverfasser:	Shoeib, Amal M., Yarbrough, Azure L., Ford, Benjamin M., Franks, Lirit N., Urbaniak, Alicja, Hensley, Lori L., Benson, Lance N., Mu, Shengyu, Radominska-Pandya, Anna, Prather, Paul L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate cyclase Affinity Antineoplastic Agents - pharmacology Antitumor agents Benzoxazines - pharmacology Binding Binding, Competitive Cannabidiol Cannabinoid CB1 receptors Cannabinoid CB2 receptors Cannabinoid receptors Cannabinoids - pharmacology Cell Line, Tumor Cell viability Cytotoxicity Cytotoxins - pharmacology Drug Development Ewing sarcoma Ewing's sarcoma Ewings sarcoma Homology Humans Ligands Morpholines - pharmacology mRNA Naphthalenes - pharmacology Proteins Receptor mechanisms Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - metabolism Receptor, Cannabinoid, CB2 - agonists Receptor, Cannabinoid, CB2 - metabolism Receptors Sarcoma Sarcoma, Ewing - metabolism Toxicity Tumor cell lines WIN-55,212-2
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