Cardiomyocyte nuclear remodeling after mechanical unloading

Cardiomyocytes increase DNA content in response to stress in humans. DNA content is reported to decrease in association with increased markers of proliferation in cardiomyocytes following left ventricular assist device (LVAD) unloading. However, cardiac recovery resulting in LVAD explant is rare. Th...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2023-08, Vol.325 (2), p.H244-H251
Hauptverfasser:	Luo, Jun, Farris, Stephen D, Helterline, Deri, Stempien-Otero, April
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiomyocytes Cell Nucleus Cell size Deoxyribonucleic acid DNA Flow cytometry Heart Heart Failure Heart Transplantation Heart-Assist Devices Humans Mechanical unloading Myocardium Myocytes, Cardiac Nucleation Nuclei Transplantation Ventricle Ventricular assist devices Ventricular Remodeling - physiology Yeast
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