Portal vein thrombosis in patients with hepatocellular carcinoma and early cirrhosis-prevalence and risk factors
Hepatocellular carcinoma (HCC) is frequently associated with portal vein thrombosis (PVT) with prevalence ranging from 25% to 50%. PVT is associated with poor prognosis, limiting the available therapeutic options for these patients. Our objective was to determine the prevalence and risk factors for...
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| Veröffentlicht in: | Ecancermedicalscience 2023, Vol.17, p.1581 |
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| creator | Siddiqui, Muhammad Tayyab Ul-Hasan Fareed, Ghulam Khan, Muhammad Rizwan Riaz, Amna Hamid, Saeed Sadiq |
| description | Hepatocellular carcinoma (HCC) is frequently associated with portal vein thrombosis (PVT) with prevalence ranging from 25% to 50%. PVT is associated with poor prognosis, limiting the available therapeutic options for these patients. Our objective was to determine the prevalence and risk factors for PVT in patients with HCC.
A retrospective analysis was performed on the prospectively collected data from January 2018 to March 2020. All patients with HCC discussed in our weekly multidisciplinary liver clinic were reviewed. Multivariate analysis was done to identify the independent risk factors for PVT in HCC patients. A
-value of |
| doi_str_mv | 10.3332/ecancer.2023.1581 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10393302</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2859507629</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-f0719dc2146e511660f2ef1e7eef29c3b40d2f9ebf64796a43c0eb71edce166c3</originalsourceid><addsrcrecordid>eNpdkU1v1DAQhi0EomXhB3BBlrhwyeKP2KlPCFV8SZXgAGfL8Y6JSxKHsbOo_x6HLlXhZM_MM6N55yXkOWd7KaV4Dd7NHnAvmJB7ri74A3LOO9U2WjP18N7_jDzJ-ZoxzY1Qj8mZ7JSUplXnZPmSsLiRHiHOtAyYpj7lmGmNFlcizCXTX7EMdIAaJw_juI4OqXfo45wmR918oOBwvKE-Ig5bd7MgHN0Idbk_ZYz5Bw3Ol4T5KXkU3Jjh2endkW_v3329_Nhcff7w6fLtVeOl7EoTWMfNwQvealCcVxFBQODQAQRhvOxbdhDBQB902xntWukZ9B2Hg4dKe7kjb27nLms_bdm5oBvtgnFyeGOTi_bfyhwH-z0dLWfSSFkvuiOvThMw_VwhFzvFvB3AzZDWbMVFq7TSrJUVffkfep1WnKu-SimjWKeFqRS_pTymnBHC3Tac2c1QezLUbobazdDa8-K-jLuOvw7K3yaVoT8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2859507629</pqid></control><display><type>article</type><title>Portal vein thrombosis in patients with hepatocellular carcinoma and early cirrhosis-prevalence and risk factors</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Siddiqui, Muhammad Tayyab Ul-Hasan ; Fareed, Ghulam ; Khan, Muhammad Rizwan ; Riaz, Amna ; Hamid, Saeed Sadiq</creator><creatorcontrib>Siddiqui, Muhammad Tayyab Ul-Hasan ; Fareed, Ghulam ; Khan, Muhammad Rizwan ; Riaz, Amna ; Hamid, Saeed Sadiq</creatorcontrib><description>Hepatocellular carcinoma (HCC) is frequently associated with portal vein thrombosis (PVT) with prevalence ranging from 25% to 50%. PVT is associated with poor prognosis, limiting the available therapeutic options for these patients. Our objective was to determine the prevalence and risk factors for PVT in patients with HCC.
A retrospective analysis was performed on the prospectively collected data from January 2018 to March 2020. All patients with HCC discussed in our weekly multidisciplinary liver clinic were reviewed. Multivariate analysis was done to identify the independent risk factors for PVT in HCC patients. A
-value of <0.05 was considered significant.
Of 316 patients, the prevalence of PVT was 31% (
= 98). Larger tumour size (
< 0.001), raised Alpha Fetoprotein (AFP) level (
= 0.036) and higher Child-Pugh class (
= 0.008) were significantly associated with PVT. In 216 patients with preserved liver function (Child-Pugh class A), PVT was seen in 53 (24.5%) patients. Large tumour size (
< 0.001) and higher AFP levels (
= 0.021) were independent risk factors.
Overall prevalence of PVT in HCC was 31% whereas 24.5% in patients with early cirrhosis (Child-Pugh class A). We identified various risk factors associated with PVT in our local population, highlighting the importance of early and regular screening of cirrhotic patients including Child-Pugh class A.</description><identifier>ISSN: 1754-6605</identifier><identifier>EISSN: 1754-6605</identifier><identifier>DOI: 10.3332/ecancer.2023.1581</identifier><identifier>PMID: 37533945</identifier><language>eng</language><publisher>England: Cancer Intelligence</publisher><subject>Blood clots ; Clinical Study ; Comorbidity ; Flow velocity ; Hepatitis C ; Hospitals ; Liver cancer ; Liver cirrhosis ; Liver diseases ; Medical prognosis ; Meetings ; Multivariate analysis ; Patients ; Population ; Regression analysis ; Risk factors ; Thrombosis ; Veins & arteries</subject><ispartof>Ecancermedicalscience, 2023, Vol.17, p.1581</ispartof><rights>the authors; licensee ecancermedicalscience.</rights><rights>the authors; licensee e cancermedicalscience. 2023. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>the authors; licensee cancermedicalscience. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393302/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393302/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,4009,27902,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37533945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siddiqui, Muhammad Tayyab Ul-Hasan</creatorcontrib><creatorcontrib>Fareed, Ghulam</creatorcontrib><creatorcontrib>Khan, Muhammad Rizwan</creatorcontrib><creatorcontrib>Riaz, Amna</creatorcontrib><creatorcontrib>Hamid, Saeed Sadiq</creatorcontrib><title>Portal vein thrombosis in patients with hepatocellular carcinoma and early cirrhosis-prevalence and risk factors</title><title>Ecancermedicalscience</title><addtitle>Ecancermedicalscience</addtitle><description>Hepatocellular carcinoma (HCC) is frequently associated with portal vein thrombosis (PVT) with prevalence ranging from 25% to 50%. PVT is associated with poor prognosis, limiting the available therapeutic options for these patients. Our objective was to determine the prevalence and risk factors for PVT in patients with HCC.
A retrospective analysis was performed on the prospectively collected data from January 2018 to March 2020. All patients with HCC discussed in our weekly multidisciplinary liver clinic were reviewed. Multivariate analysis was done to identify the independent risk factors for PVT in HCC patients. A
-value of <0.05 was considered significant.
Of 316 patients, the prevalence of PVT was 31% (
= 98). Larger tumour size (
< 0.001), raised Alpha Fetoprotein (AFP) level (
= 0.036) and higher Child-Pugh class (
= 0.008) were significantly associated with PVT. In 216 patients with preserved liver function (Child-Pugh class A), PVT was seen in 53 (24.5%) patients. Large tumour size (
< 0.001) and higher AFP levels (
= 0.021) were independent risk factors.
Overall prevalence of PVT in HCC was 31% whereas 24.5% in patients with early cirrhosis (Child-Pugh class A). We identified various risk factors associated with PVT in our local population, highlighting the importance of early and regular screening of cirrhotic patients including Child-Pugh class A.</description><subject>Blood clots</subject><subject>Clinical Study</subject><subject>Comorbidity</subject><subject>Flow velocity</subject><subject>Hepatitis C</subject><subject>Hospitals</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Medical prognosis</subject><subject>Meetings</subject><subject>Multivariate analysis</subject><subject>Patients</subject><subject>Population</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Thrombosis</subject><subject>Veins & arteries</subject><issn>1754-6605</issn><issn>1754-6605</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkU1v1DAQhi0EomXhB3BBlrhwyeKP2KlPCFV8SZXgAGfL8Y6JSxKHsbOo_x6HLlXhZM_MM6N55yXkOWd7KaV4Dd7NHnAvmJB7ri74A3LOO9U2WjP18N7_jDzJ-ZoxzY1Qj8mZ7JSUplXnZPmSsLiRHiHOtAyYpj7lmGmNFlcizCXTX7EMdIAaJw_juI4OqXfo45wmR918oOBwvKE-Ig5bd7MgHN0Idbk_ZYz5Bw3Ol4T5KXkU3Jjh2endkW_v3329_Nhcff7w6fLtVeOl7EoTWMfNwQvealCcVxFBQODQAQRhvOxbdhDBQB902xntWukZ9B2Hg4dKe7kjb27nLms_bdm5oBvtgnFyeGOTi_bfyhwH-z0dLWfSSFkvuiOvThMw_VwhFzvFvB3AzZDWbMVFq7TSrJUVffkfep1WnKu-SimjWKeFqRS_pTymnBHC3Tac2c1QezLUbobazdDa8-K-jLuOvw7K3yaVoT8</recordid><startdate>2023</startdate><enddate>2023</enddate><creator>Siddiqui, Muhammad Tayyab Ul-Hasan</creator><creator>Fareed, Ghulam</creator><creator>Khan, Muhammad Rizwan</creator><creator>Riaz, Amna</creator><creator>Hamid, Saeed Sadiq</creator><general>Cancer Intelligence</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2023</creationdate><title>Portal vein thrombosis in patients with hepatocellular carcinoma and early cirrhosis-prevalence and risk factors</title><author>Siddiqui, Muhammad Tayyab Ul-Hasan ; Fareed, Ghulam ; Khan, Muhammad Rizwan ; Riaz, Amna ; Hamid, Saeed Sadiq</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-f0719dc2146e511660f2ef1e7eef29c3b40d2f9ebf64796a43c0eb71edce166c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Blood clots</topic><topic>Clinical Study</topic><topic>Comorbidity</topic><topic>Flow velocity</topic><topic>Hepatitis C</topic><topic>Hospitals</topic><topic>Liver cancer</topic><topic>Liver cirrhosis</topic><topic>Liver diseases</topic><topic>Medical prognosis</topic><topic>Meetings</topic><topic>Multivariate analysis</topic><topic>Patients</topic><topic>Population</topic><topic>Regression analysis</topic><topic>Risk factors</topic><topic>Thrombosis</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siddiqui, Muhammad Tayyab Ul-Hasan</creatorcontrib><creatorcontrib>Fareed, Ghulam</creatorcontrib><creatorcontrib>Khan, Muhammad Rizwan</creatorcontrib><creatorcontrib>Riaz, Amna</creatorcontrib><creatorcontrib>Hamid, Saeed Sadiq</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Ecancermedicalscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siddiqui, Muhammad Tayyab Ul-Hasan</au><au>Fareed, Ghulam</au><au>Khan, Muhammad Rizwan</au><au>Riaz, Amna</au><au>Hamid, Saeed Sadiq</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Portal vein thrombosis in patients with hepatocellular carcinoma and early cirrhosis-prevalence and risk factors</atitle><jtitle>Ecancermedicalscience</jtitle><addtitle>Ecancermedicalscience</addtitle><date>2023</date><risdate>2023</risdate><volume>17</volume><spage>1581</spage><pages>1581-</pages><issn>1754-6605</issn><eissn>1754-6605</eissn><abstract>Hepatocellular carcinoma (HCC) is frequently associated with portal vein thrombosis (PVT) with prevalence ranging from 25% to 50%. PVT is associated with poor prognosis, limiting the available therapeutic options for these patients. Our objective was to determine the prevalence and risk factors for PVT in patients with HCC.
A retrospective analysis was performed on the prospectively collected data from January 2018 to March 2020. All patients with HCC discussed in our weekly multidisciplinary liver clinic were reviewed. Multivariate analysis was done to identify the independent risk factors for PVT in HCC patients. A
-value of <0.05 was considered significant.
Of 316 patients, the prevalence of PVT was 31% (
= 98). Larger tumour size (
< 0.001), raised Alpha Fetoprotein (AFP) level (
= 0.036) and higher Child-Pugh class (
= 0.008) were significantly associated with PVT. In 216 patients with preserved liver function (Child-Pugh class A), PVT was seen in 53 (24.5%) patients. Large tumour size (
< 0.001) and higher AFP levels (
= 0.021) were independent risk factors.
Overall prevalence of PVT in HCC was 31% whereas 24.5% in patients with early cirrhosis (Child-Pugh class A). We identified various risk factors associated with PVT in our local population, highlighting the importance of early and regular screening of cirrhotic patients including Child-Pugh class A.</abstract><cop>England</cop><pub>Cancer Intelligence</pub><pmid>37533945</pmid><doi>10.3332/ecancer.2023.1581</doi><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Blood clots Clinical Study Comorbidity Flow velocity Hepatitis C Hospitals Liver cancer Liver cirrhosis Liver diseases Medical prognosis Meetings Multivariate analysis Patients Population Regression analysis Risk factors Thrombosis Veins & arteries |
| title | Portal vein thrombosis in patients with hepatocellular carcinoma and early cirrhosis-prevalence and risk factors |
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