Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines

Mycobacteria, such as Mycobacterium tuberculosis , depend on the activity of adenosine triphosphate (ATP) synthase for growth. The diarylquinoline bedaquiline (BDQ), a mycobacterial ATP synthase inhibitor, is an important medication for treatment of drug‐resistant tuberculosis but suffers from off‐t...

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Veröffentlicht in:	The EMBO journal 2023-08, Vol.42 (15), p.e113687-n/a
Hauptverfasser:	Courbon, Gautier M, Palme, Paul R, Mann, Lea, Richter, Adrian, Imming, Peter, Rubinstein, John L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphate Adenosine Triphosphate - metabolism Antitubercular Agents - chemistry Antitubercular Agents - metabolism Antitubercular Agents - pharmacology Aromatic compounds ATP ATP synthase Binding Conformation diarylquinoline Diarylquinolines - pharmacology Electrochemistry EMBO23 EMBO40 inhibitor Life Sciences Membrane vesicles mycobacterial Mycobacterium tuberculosis - genetics Protonmotive force Protons squaramide Tuberculosis
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