Fluorescent Ligands Enable Target Engagement Studies for the Intracellular Allosteric Binding Site of the Chemokine Receptor CXCR2

Herein, we report the structure-based development of fluorescent ligands targeting the intracellular allosteric binding site (IABS) of CXC chemokine receptor 2 (CXCR2), a G protein-coupled receptor (GPCR) that has been pursued as a drug target in oncology and inflammation. Starting from the cocrysta...

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Veröffentlicht in:	Journal of medicinal chemistry 2023-07, Vol.66 (14), p.9916-9933
Hauptverfasser:	Huber, Max E., Wurnig, Silas, Toy, Lara, Weiler, Corinna, Merten, Nicole, Kostenis, Evi, Hansen, Finn K., Schiedel, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Site Ligands Protein Binding Receptors, G-Protein-Coupled - metabolism Receptors, Interleukin-8B
Online-Zugang:	Volltext
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