Effects of Androgens on the Thickness of Retinal Layers in Transgender Men and in Women with Polycystic Ovarian Syndrome
Purpose: This study aimed to evaluate the relationship between androgens and the retinal thickness by comparing the macular thickness (MT), retinal nerve fiber layer (RNFL), and ganglion cell complex (GCC) thickness of female-to-male transgender men (TGM), women with polycystic ovary syndrome (PCOS)...
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| Veröffentlicht in: | Transgender health 2023-08, Vol.8 (4), p.363-370 |
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| creator | Alpogan, Oksan Donmez, Emin Erhan Vural, Fisun Balık, Ayşe Özlem |
| description | Purpose:
This study aimed to evaluate the relationship between androgens and the retinal thickness by comparing the macular thickness (MT), retinal nerve fiber layer (RNFL), and ganglion cell complex (GCC) thickness of female-to-male transgender men (TGM), women with polycystic ovary syndrome (PCOS), and cisgender women (CW).
Methods:
Thirty-four eyes of 34 TGM, 34 eyes of 34 women with PCOS, and 45 eyes of 45 CW were evaluated by optical coherence tomography. One-way analysis of variance and body mass index (BMI)-adjusted one-way analysis of covariance were conducted to test the differences between groups for statistical evaluation.
Results:
The parafoveal MT in TGM was significantly higher than women with PCOS and CW (
p |
| doi_str_mv | 10.1089/trgh.2022.0061 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10387147</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2844678808</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-93b7ecd8d9aba2bd1bf1507c7632323ac0a5e5ce8394352ef1b7f690776464f13</originalsourceid><addsrcrecordid>eNqFkcFvFSEQxjdGY5vaq0dD4sXLvsLCLnAyTVO1yWtq9Bm9EZadfUvdhRZ41f3vZX1to14Mh2FmfnwMfEXxkuAVwUKepLAdVhWuqhXGDXlSHFZU4JJI-u1p3jdClEwIflAcx3iNMSY1E3WNnxcHlNdVLag4LH6e9z2YFJHv0anrgt-Cy4lDaQC0Gaz57iD-7n6CZJ0e0VrPECKyDm2CdjHzHQR0CQ5p1y3lr37KyQ-bBvTRj7OZY7IGXd3pYLVDn-fllgleFM96PUY4vo9HxZd355uzD-X66v3F2em6NIzIVEracjCd6KRuddV2pO1JjbnhDa3y0gbrGmoDgkpG6wp60vK-kZjzhjWsJ_SoeLvXvdm1E3QGXAp6VDfBTjrMymur_u44O6itv1MEU8EJ41nhzb1C8Lc7iElNNhoYR-3A76KqBGMNFwKLjL7-B732u5B_bU8RKWQjM7XaUyb4GAP0j9MQrBZj1WKsWoxVi7H5wKs_3_CIP9iYAbYHlrJ2brTQQkj_0_0FP7ex_w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2844198969</pqid></control><display><type>article</type><title>Effects of Androgens on the Thickness of Retinal Layers in Transgender Men and in Women with Polycystic Ovarian Syndrome</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Alpogan, Oksan ; Donmez, Emin Erhan ; Vural, Fisun ; Balık, Ayşe Özlem</creator><creatorcontrib>Alpogan, Oksan ; Donmez, Emin Erhan ; Vural, Fisun ; Balık, Ayşe Özlem</creatorcontrib><description>Purpose:
This study aimed to evaluate the relationship between androgens and the retinal thickness by comparing the macular thickness (MT), retinal nerve fiber layer (RNFL), and ganglion cell complex (GCC) thickness of female-to-male transgender men (TGM), women with polycystic ovary syndrome (PCOS), and cisgender women (CW).
Methods:
Thirty-four eyes of 34 TGM, 34 eyes of 34 women with PCOS, and 45 eyes of 45 CW were evaluated by optical coherence tomography. One-way analysis of variance and body mass index (BMI)-adjusted one-way analysis of covariance were conducted to test the differences between groups for statistical evaluation.
Results:
The parafoveal MT in TGM was significantly higher than women with PCOS and CW (
p
<0.001 and
p
=0.022, respectively). After adjusting for BMI, the perifoveal MT in TGM was significantly higher than women with PCOS and CW (
p
=0.041 and
p
=0.021, respectively). The nasal RNFL thickness in TGM was significantly higher than women with PCOS and CW (
p
=0.021 and
p
=0.009, respectively). The means of average and inferior RNFL, fovea, and the mean of all GCC values were higher in the TGM group than women with PCOS and CW, but these results were not statistically significant.
Conclusions:
In this study, there was a significant difference between the TGM group and the CW group for the thickness of the nasal RNFL and parafoveal and perifoveal macular area. Androgens may have the potential to increase retinal thickness in TGM; however, there is a need for validation in larger study groups. Clinical Trial Registration Number: HNEAH-KAEK 2021/4.</description><identifier>ISSN: 2688-4887</identifier><identifier>EISSN: 2380-193X</identifier><identifier>DOI: 10.1089/trgh.2022.0061</identifier><identifier>PMID: 37525838</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc., publishers</publisher><subject>Analysis of covariance ; Androgens ; Body mass index ; Cornea ; Data collection ; Disease ; Estrogens ; Gynecology ; Hormones ; Hysterectomy ; Menstruation ; Obstetrics ; Oophorectomy ; Optics ; Original ; Ovaries ; Polycystic ovary syndrome ; Statistical analysis ; Testosterone ; Transgender persons ; Variance analysis ; Visual acuity ; Womens health</subject><ispartof>Transgender health, 2023-08, Vol.8 (4), p.363-370</ispartof><rights>2022, Mary Ann Liebert, Inc., publishers</rights><rights>Copyright 2023, Mary Ann Liebert, Inc., publishers.</rights><rights>Copyright Mary Ann Liebert, Inc. Aug 2023</rights><rights>Copyright 2023, Mary Ann Liebert, Inc., publishers 2023 Mary Ann Liebert, Inc., publishers</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c419t-93b7ecd8d9aba2bd1bf1507c7632323ac0a5e5ce8394352ef1b7f690776464f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387147/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387147/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37525838$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alpogan, Oksan</creatorcontrib><creatorcontrib>Donmez, Emin Erhan</creatorcontrib><creatorcontrib>Vural, Fisun</creatorcontrib><creatorcontrib>Balık, Ayşe Özlem</creatorcontrib><title>Effects of Androgens on the Thickness of Retinal Layers in Transgender Men and in Women with Polycystic Ovarian Syndrome</title><title>Transgender health</title><addtitle>Transgend Health</addtitle><description>Purpose:
This study aimed to evaluate the relationship between androgens and the retinal thickness by comparing the macular thickness (MT), retinal nerve fiber layer (RNFL), and ganglion cell complex (GCC) thickness of female-to-male transgender men (TGM), women with polycystic ovary syndrome (PCOS), and cisgender women (CW).
Methods:
Thirty-four eyes of 34 TGM, 34 eyes of 34 women with PCOS, and 45 eyes of 45 CW were evaluated by optical coherence tomography. One-way analysis of variance and body mass index (BMI)-adjusted one-way analysis of covariance were conducted to test the differences between groups for statistical evaluation.
Results:
The parafoveal MT in TGM was significantly higher than women with PCOS and CW (
p
<0.001 and
p
=0.022, respectively). After adjusting for BMI, the perifoveal MT in TGM was significantly higher than women with PCOS and CW (
p
=0.041 and
p
=0.021, respectively). The nasal RNFL thickness in TGM was significantly higher than women with PCOS and CW (
p
=0.021 and
p
=0.009, respectively). The means of average and inferior RNFL, fovea, and the mean of all GCC values were higher in the TGM group than women with PCOS and CW, but these results were not statistically significant.
Conclusions:
In this study, there was a significant difference between the TGM group and the CW group for the thickness of the nasal RNFL and parafoveal and perifoveal macular area. Androgens may have the potential to increase retinal thickness in TGM; however, there is a need for validation in larger study groups. Clinical Trial Registration Number: HNEAH-KAEK 2021/4.</description><subject>Analysis of covariance</subject><subject>Androgens</subject><subject>Body mass index</subject><subject>Cornea</subject><subject>Data collection</subject><subject>Disease</subject><subject>Estrogens</subject><subject>Gynecology</subject><subject>Hormones</subject><subject>Hysterectomy</subject><subject>Menstruation</subject><subject>Obstetrics</subject><subject>Oophorectomy</subject><subject>Optics</subject><subject>Original</subject><subject>Ovaries</subject><subject>Polycystic ovary syndrome</subject><subject>Statistical analysis</subject><subject>Testosterone</subject><subject>Transgender persons</subject><subject>Variance analysis</subject><subject>Visual acuity</subject><subject>Womens health</subject><issn>2688-4887</issn><issn>2380-193X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqFkcFvFSEQxjdGY5vaq0dD4sXLvsLCLnAyTVO1yWtq9Bm9EZadfUvdhRZ41f3vZX1to14Mh2FmfnwMfEXxkuAVwUKepLAdVhWuqhXGDXlSHFZU4JJI-u1p3jdClEwIflAcx3iNMSY1E3WNnxcHlNdVLag4LH6e9z2YFJHv0anrgt-Cy4lDaQC0Gaz57iD-7n6CZJ0e0VrPECKyDm2CdjHzHQR0CQ5p1y3lr37KyQ-bBvTRj7OZY7IGXd3pYLVDn-fllgleFM96PUY4vo9HxZd355uzD-X66v3F2em6NIzIVEracjCd6KRuddV2pO1JjbnhDa3y0gbrGmoDgkpG6wp60vK-kZjzhjWsJ_SoeLvXvdm1E3QGXAp6VDfBTjrMymur_u44O6itv1MEU8EJ41nhzb1C8Lc7iElNNhoYR-3A76KqBGMNFwKLjL7-B732u5B_bU8RKWQjM7XaUyb4GAP0j9MQrBZj1WKsWoxVi7H5wKs_3_CIP9iYAbYHlrJ2brTQQkj_0_0FP7ex_w</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Alpogan, Oksan</creator><creator>Donmez, Emin Erhan</creator><creator>Vural, Fisun</creator><creator>Balık, Ayşe Özlem</creator><general>Mary Ann Liebert, Inc., publishers</general><general>Mary Ann Liebert, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230801</creationdate><title>Effects of Androgens on the Thickness of Retinal Layers in Transgender Men and in Women with Polycystic Ovarian Syndrome</title><author>Alpogan, Oksan ; Donmez, Emin Erhan ; Vural, Fisun ; Balık, Ayşe Özlem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-93b7ecd8d9aba2bd1bf1507c7632323ac0a5e5ce8394352ef1b7f690776464f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Analysis of covariance</topic><topic>Androgens</topic><topic>Body mass index</topic><topic>Cornea</topic><topic>Data collection</topic><topic>Disease</topic><topic>Estrogens</topic><topic>Gynecology</topic><topic>Hormones</topic><topic>Hysterectomy</topic><topic>Menstruation</topic><topic>Obstetrics</topic><topic>Oophorectomy</topic><topic>Optics</topic><topic>Original</topic><topic>Ovaries</topic><topic>Polycystic ovary syndrome</topic><topic>Statistical analysis</topic><topic>Testosterone</topic><topic>Transgender persons</topic><topic>Variance analysis</topic><topic>Visual acuity</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alpogan, Oksan</creatorcontrib><creatorcontrib>Donmez, Emin Erhan</creatorcontrib><creatorcontrib>Vural, Fisun</creatorcontrib><creatorcontrib>Balık, Ayşe Özlem</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Transgender health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alpogan, Oksan</au><au>Donmez, Emin Erhan</au><au>Vural, Fisun</au><au>Balık, Ayşe Özlem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Androgens on the Thickness of Retinal Layers in Transgender Men and in Women with Polycystic Ovarian Syndrome</atitle><jtitle>Transgender health</jtitle><addtitle>Transgend Health</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>8</volume><issue>4</issue><spage>363</spage><epage>370</epage><pages>363-370</pages><issn>2688-4887</issn><eissn>2380-193X</eissn><abstract>Purpose:
This study aimed to evaluate the relationship between androgens and the retinal thickness by comparing the macular thickness (MT), retinal nerve fiber layer (RNFL), and ganglion cell complex (GCC) thickness of female-to-male transgender men (TGM), women with polycystic ovary syndrome (PCOS), and cisgender women (CW).
Methods:
Thirty-four eyes of 34 TGM, 34 eyes of 34 women with PCOS, and 45 eyes of 45 CW were evaluated by optical coherence tomography. One-way analysis of variance and body mass index (BMI)-adjusted one-way analysis of covariance were conducted to test the differences between groups for statistical evaluation.
Results:
The parafoveal MT in TGM was significantly higher than women with PCOS and CW (
p
<0.001 and
p
=0.022, respectively). After adjusting for BMI, the perifoveal MT in TGM was significantly higher than women with PCOS and CW (
p
=0.041 and
p
=0.021, respectively). The nasal RNFL thickness in TGM was significantly higher than women with PCOS and CW (
p
=0.021 and
p
=0.009, respectively). The means of average and inferior RNFL, fovea, and the mean of all GCC values were higher in the TGM group than women with PCOS and CW, but these results were not statistically significant.
Conclusions:
In this study, there was a significant difference between the TGM group and the CW group for the thickness of the nasal RNFL and parafoveal and perifoveal macular area. Androgens may have the potential to increase retinal thickness in TGM; however, there is a need for validation in larger study groups. Clinical Trial Registration Number: HNEAH-KAEK 2021/4.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc., publishers</pub><pmid>37525838</pmid><doi>10.1089/trgh.2022.0061</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 2688-4887 |
| ispartof | Transgender health, 2023-08, Vol.8 (4), p.363-370 |
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| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Analysis of covariance Androgens Body mass index Cornea Data collection Disease Estrogens Gynecology Hormones Hysterectomy Menstruation Obstetrics Oophorectomy Optics Original Ovaries Polycystic ovary syndrome Statistical analysis Testosterone Transgender persons Variance analysis Visual acuity Womens health |
| title | Effects of Androgens on the Thickness of Retinal Layers in Transgender Men and in Women with Polycystic Ovarian Syndrome |
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