Mechanism of Cell Death by Combined Treatment with an xCT Inhibitor and Paclitaxel: An Alternative Therapeutic Strategy for Patients with Ovarian Clear Cell Carcinoma

Ovarian clear cell carcinoma (OCCC) is a rare subtype of epithelial ovarian carcinoma that responds poorly to chemotherapy. Glutathione (GSH) is a primary antioxidant, which protects cells against reactive oxygen species (ROS). High levels of GSH are related to chemotherapeutic resistance. The gluta...

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Veröffentlicht in:	International journal of molecular sciences 2023-07, Vol.24 (14), p.11781
Hauptverfasser:	Idei, Urara, Ohta, Tsuyoshi, Yamatani, Hizuru, Seino, Manabu, Nagase, Satoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biochemistry Cancer Cancer therapies Carcinoma Cell Death Cell Line, Tumor Chemotherapy Cytotoxicity Ferroptosis Glutathione - metabolism Health aspects Humans Lipid peroxidation Lipids Ovarian cancer Paclitaxel Paclitaxel - pharmacology Paclitaxel - therapeutic use Reactive oxygen species Reactive Oxygen Species - metabolism Scientific equipment and supplies industry Sulfasalazine - pharmacology Sulfasalazine - therapeutic use Thiols Uterine cancer
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