Synthesis of Prostate-Specific Membrane Antigen-Targeted Bimodal Conjugates of Cytotoxic Agents and Antiandrogens and Their Comparative Assessment with Monoconjugates
Prostate cancer is the second most common cancer among men. We designed and synthesized new ligands targeting prostate-specific membrane antigen and suitable for bimodal conjugates with diagnostic and therapeutic agents. studies of the affinity of the synthesized compounds to the protein target have...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2023-07, Vol.24 (14), p.11327 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 14 |
| container_start_page | 11327 |
| container_title | International journal of molecular sciences |
| container_volume | 24 |
| creator | Zyk, Nikolai Y Garanina, Anastasiia S Plotnikova, Ekaterina A Ber, Anton P Nimenko, Ekaterina A Dashkova, Natalia S Uspenskaia, Anastasiia A Shafikov, Radik R Skvortsov, Dmitry A Petrov, Stanislav A Pankratov, Andrey A Zyk, Nikolai V Majouga, Alexander G Beloglazkina, Elena K Machulkin, Aleksei E |
| description | Prostate cancer is the second most common cancer among men. We designed and synthesized new ligands targeting prostate-specific membrane antigen and suitable for bimodal conjugates with diagnostic and therapeutic agents.
studies of the affinity of the synthesized compounds to the protein target have been carried out. Based on these ligands, a series of bimodal conjugates with a combination of different mitosis inhibitors and antiandrogenic drugs were synthesized. The cytotoxicity of the compounds obtained
was investigated on three different cell lines. The efficacy of the two obtained conjugates was evaluated
in xenograft models of prostate cancer. These compounds have been shown to be highly effective in inhibiting the growth of PSMA-expressing tumors. |
| doi_str_mv | 10.3390/ijms241411327 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10380083</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A759152810</galeid><sourcerecordid>A759152810</sourcerecordid><originalsourceid>FETCH-LOGICAL-c483t-fa5186a908b099c217bb86f45d0b58b9ce8fb68dac36652e59397de15cbf923b3</originalsourceid><addsrcrecordid>eNptkk1vEzEQhlcIREvgyBWtxIXLFn-sd-0TSiO-pFYgNZwt2ztOHO2ug-0t5A_xO3GaEhqEfBhr_Lzv2OMpipcYXVAq0Fu3GSKpcY0xJe2j4hzXhFQINe3jB_uz4lmMG4QIJUw8Lc5oyzBGvD0vft3sxrSG6GLpbfk1-JhUgupmC8ZZZ8prGHRQI5TzMbkVjNVShRUk6MpLN_hO9eXCj5tplUV3Dotd8sn_zMp5plMs1djdaXMMPqcOmeUaXMjSYauCSu42-8cIMQ5ZU_5waV1e-9Gbo_Xz4olVfYQX93FWfPvwfrn4VF19-fh5Mb-qTM1pqqximDdKIK6REIbgVmve2Jp1SDOuhQFudcM7ZWjTMAJMUNF2gJnRVhCq6ax4d_DdTnqAzuTrBNXLbXCDCjvplZOnJ6Nby5W_lRhRjhCn2eHNvUPw3yeISQ4uGuj73EQ_RUl4XSMuasQy-vofdOOnMOb37SmKWtQQ8ZdaqR6kG63Phc3eVM5bJjAjPBefFRf_ofLqYHC5j2Bdzp8IqoPA5D-PAezxkRjJ_WTJk8nK_KuHnTnSf0aJ_gbv6cy1</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2843070629</pqid></control><display><type>article</type><title>Synthesis of Prostate-Specific Membrane Antigen-Targeted Bimodal Conjugates of Cytotoxic Agents and Antiandrogens and Their Comparative Assessment with Monoconjugates</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Zyk, Nikolai Y ; Garanina, Anastasiia S ; Plotnikova, Ekaterina A ; Ber, Anton P ; Nimenko, Ekaterina A ; Dashkova, Natalia S ; Uspenskaia, Anastasiia A ; Shafikov, Radik R ; Skvortsov, Dmitry A ; Petrov, Stanislav A ; Pankratov, Andrey A ; Zyk, Nikolai V ; Majouga, Alexander G ; Beloglazkina, Elena K ; Machulkin, Aleksei E</creator><creatorcontrib>Zyk, Nikolai Y ; Garanina, Anastasiia S ; Plotnikova, Ekaterina A ; Ber, Anton P ; Nimenko, Ekaterina A ; Dashkova, Natalia S ; Uspenskaia, Anastasiia A ; Shafikov, Radik R ; Skvortsov, Dmitry A ; Petrov, Stanislav A ; Pankratov, Andrey A ; Zyk, Nikolai V ; Majouga, Alexander G ; Beloglazkina, Elena K ; Machulkin, Aleksei E</creatorcontrib><description>Prostate cancer is the second most common cancer among men. We designed and synthesized new ligands targeting prostate-specific membrane antigen and suitable for bimodal conjugates with diagnostic and therapeutic agents.
studies of the affinity of the synthesized compounds to the protein target have been carried out. Based on these ligands, a series of bimodal conjugates with a combination of different mitosis inhibitors and antiandrogenic drugs were synthesized. The cytotoxicity of the compounds obtained
was investigated on three different cell lines. The efficacy of the two obtained conjugates was evaluated
in xenograft models of prostate cancer. These compounds have been shown to be highly effective in inhibiting the growth of PSMA-expressing tumors.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms241411327</identifier><identifier>PMID: 37511087</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Amino acids ; Androgen Antagonists - therapeutic use ; Antiandrogens ; Antigens ; Antigens, Surface - metabolism ; Cancer therapies ; Cell Line, Tumor ; Comparative analysis ; Cytotoxins - therapeutic use ; Drugs ; Glutamate Carboxypeptidase II - metabolism ; Health aspects ; Humans ; Ligands ; Male ; Peptides ; Prostate ; Prostate - pathology ; Prostate cancer ; Prostatic Neoplasms - metabolism ; Proteins</subject><ispartof>International journal of molecular sciences, 2023-07, Vol.24 (14), p.11327</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-fa5186a908b099c217bb86f45d0b58b9ce8fb68dac36652e59397de15cbf923b3</citedby><cites>FETCH-LOGICAL-c483t-fa5186a908b099c217bb86f45d0b58b9ce8fb68dac36652e59397de15cbf923b3</cites><orcidid>0000-0002-5302-9160 ; 0000-0001-7975-0346 ; 0000-0001-6796-8241 ; 0000-0002-6000-6100 ; 0000-0003-3442-9553 ; 0000-0001-8711-6919</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380083/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380083/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37511087$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zyk, Nikolai Y</creatorcontrib><creatorcontrib>Garanina, Anastasiia S</creatorcontrib><creatorcontrib>Plotnikova, Ekaterina A</creatorcontrib><creatorcontrib>Ber, Anton P</creatorcontrib><creatorcontrib>Nimenko, Ekaterina A</creatorcontrib><creatorcontrib>Dashkova, Natalia S</creatorcontrib><creatorcontrib>Uspenskaia, Anastasiia A</creatorcontrib><creatorcontrib>Shafikov, Radik R</creatorcontrib><creatorcontrib>Skvortsov, Dmitry A</creatorcontrib><creatorcontrib>Petrov, Stanislav A</creatorcontrib><creatorcontrib>Pankratov, Andrey A</creatorcontrib><creatorcontrib>Zyk, Nikolai V</creatorcontrib><creatorcontrib>Majouga, Alexander G</creatorcontrib><creatorcontrib>Beloglazkina, Elena K</creatorcontrib><creatorcontrib>Machulkin, Aleksei E</creatorcontrib><title>Synthesis of Prostate-Specific Membrane Antigen-Targeted Bimodal Conjugates of Cytotoxic Agents and Antiandrogens and Their Comparative Assessment with Monoconjugates</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Prostate cancer is the second most common cancer among men. We designed and synthesized new ligands targeting prostate-specific membrane antigen and suitable for bimodal conjugates with diagnostic and therapeutic agents.
studies of the affinity of the synthesized compounds to the protein target have been carried out. Based on these ligands, a series of bimodal conjugates with a combination of different mitosis inhibitors and antiandrogenic drugs were synthesized. The cytotoxicity of the compounds obtained
was investigated on three different cell lines. The efficacy of the two obtained conjugates was evaluated
in xenograft models of prostate cancer. These compounds have been shown to be highly effective in inhibiting the growth of PSMA-expressing tumors.</description><subject>Amino acids</subject><subject>Androgen Antagonists - therapeutic use</subject><subject>Antiandrogens</subject><subject>Antigens</subject><subject>Antigens, Surface - metabolism</subject><subject>Cancer therapies</subject><subject>Cell Line, Tumor</subject><subject>Comparative analysis</subject><subject>Cytotoxins - therapeutic use</subject><subject>Drugs</subject><subject>Glutamate Carboxypeptidase II - metabolism</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Ligands</subject><subject>Male</subject><subject>Peptides</subject><subject>Prostate</subject><subject>Prostate - pathology</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Proteins</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkk1vEzEQhlcIREvgyBWtxIXLFn-sd-0TSiO-pFYgNZwt2ztOHO2ug-0t5A_xO3GaEhqEfBhr_Lzv2OMpipcYXVAq0Fu3GSKpcY0xJe2j4hzXhFQINe3jB_uz4lmMG4QIJUw8Lc5oyzBGvD0vft3sxrSG6GLpbfk1-JhUgupmC8ZZZ8prGHRQI5TzMbkVjNVShRUk6MpLN_hO9eXCj5tplUV3Dotd8sn_zMp5plMs1djdaXMMPqcOmeUaXMjSYauCSu42-8cIMQ5ZU_5waV1e-9Gbo_Xz4olVfYQX93FWfPvwfrn4VF19-fh5Mb-qTM1pqqximDdKIK6REIbgVmve2Jp1SDOuhQFudcM7ZWjTMAJMUNF2gJnRVhCq6ax4d_DdTnqAzuTrBNXLbXCDCjvplZOnJ6Nby5W_lRhRjhCn2eHNvUPw3yeISQ4uGuj73EQ_RUl4XSMuasQy-vofdOOnMOb37SmKWtQQ8ZdaqR6kG63Phc3eVM5bJjAjPBefFRf_ofLqYHC5j2Bdzp8IqoPA5D-PAezxkRjJ_WTJk8nK_KuHnTnSf0aJ_gbv6cy1</recordid><startdate>20230711</startdate><enddate>20230711</enddate><creator>Zyk, Nikolai Y</creator><creator>Garanina, Anastasiia S</creator><creator>Plotnikova, Ekaterina A</creator><creator>Ber, Anton P</creator><creator>Nimenko, Ekaterina A</creator><creator>Dashkova, Natalia S</creator><creator>Uspenskaia, Anastasiia A</creator><creator>Shafikov, Radik R</creator><creator>Skvortsov, Dmitry A</creator><creator>Petrov, Stanislav A</creator><creator>Pankratov, Andrey A</creator><creator>Zyk, Nikolai V</creator><creator>Majouga, Alexander G</creator><creator>Beloglazkina, Elena K</creator><creator>Machulkin, Aleksei E</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5302-9160</orcidid><orcidid>https://orcid.org/0000-0001-7975-0346</orcidid><orcidid>https://orcid.org/0000-0001-6796-8241</orcidid><orcidid>https://orcid.org/0000-0002-6000-6100</orcidid><orcidid>https://orcid.org/0000-0003-3442-9553</orcidid><orcidid>https://orcid.org/0000-0001-8711-6919</orcidid></search><sort><creationdate>20230711</creationdate><title>Synthesis of Prostate-Specific Membrane Antigen-Targeted Bimodal Conjugates of Cytotoxic Agents and Antiandrogens and Their Comparative Assessment with Monoconjugates</title><author>Zyk, Nikolai Y ; Garanina, Anastasiia S ; Plotnikova, Ekaterina A ; Ber, Anton P ; Nimenko, Ekaterina A ; Dashkova, Natalia S ; Uspenskaia, Anastasiia A ; Shafikov, Radik R ; Skvortsov, Dmitry A ; Petrov, Stanislav A ; Pankratov, Andrey A ; Zyk, Nikolai V ; Majouga, Alexander G ; Beloglazkina, Elena K ; Machulkin, Aleksei E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-fa5186a908b099c217bb86f45d0b58b9ce8fb68dac36652e59397de15cbf923b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Amino acids</topic><topic>Androgen Antagonists - therapeutic use</topic><topic>Antiandrogens</topic><topic>Antigens</topic><topic>Antigens, Surface - metabolism</topic><topic>Cancer therapies</topic><topic>Cell Line, Tumor</topic><topic>Comparative analysis</topic><topic>Cytotoxins - therapeutic use</topic><topic>Drugs</topic><topic>Glutamate Carboxypeptidase II - metabolism</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Ligands</topic><topic>Male</topic><topic>Peptides</topic><topic>Prostate</topic><topic>Prostate - pathology</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zyk, Nikolai Y</creatorcontrib><creatorcontrib>Garanina, Anastasiia S</creatorcontrib><creatorcontrib>Plotnikova, Ekaterina A</creatorcontrib><creatorcontrib>Ber, Anton P</creatorcontrib><creatorcontrib>Nimenko, Ekaterina A</creatorcontrib><creatorcontrib>Dashkova, Natalia S</creatorcontrib><creatorcontrib>Uspenskaia, Anastasiia A</creatorcontrib><creatorcontrib>Shafikov, Radik R</creatorcontrib><creatorcontrib>Skvortsov, Dmitry A</creatorcontrib><creatorcontrib>Petrov, Stanislav A</creatorcontrib><creatorcontrib>Pankratov, Andrey A</creatorcontrib><creatorcontrib>Zyk, Nikolai V</creatorcontrib><creatorcontrib>Majouga, Alexander G</creatorcontrib><creatorcontrib>Beloglazkina, Elena K</creatorcontrib><creatorcontrib>Machulkin, Aleksei E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zyk, Nikolai Y</au><au>Garanina, Anastasiia S</au><au>Plotnikova, Ekaterina A</au><au>Ber, Anton P</au><au>Nimenko, Ekaterina A</au><au>Dashkova, Natalia S</au><au>Uspenskaia, Anastasiia A</au><au>Shafikov, Radik R</au><au>Skvortsov, Dmitry A</au><au>Petrov, Stanislav A</au><au>Pankratov, Andrey A</au><au>Zyk, Nikolai V</au><au>Majouga, Alexander G</au><au>Beloglazkina, Elena K</au><au>Machulkin, Aleksei E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of Prostate-Specific Membrane Antigen-Targeted Bimodal Conjugates of Cytotoxic Agents and Antiandrogens and Their Comparative Assessment with Monoconjugates</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2023-07-11</date><risdate>2023</risdate><volume>24</volume><issue>14</issue><spage>11327</spage><pages>11327-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Prostate cancer is the second most common cancer among men. We designed and synthesized new ligands targeting prostate-specific membrane antigen and suitable for bimodal conjugates with diagnostic and therapeutic agents.
studies of the affinity of the synthesized compounds to the protein target have been carried out. Based on these ligands, a series of bimodal conjugates with a combination of different mitosis inhibitors and antiandrogenic drugs were synthesized. The cytotoxicity of the compounds obtained
was investigated on three different cell lines. The efficacy of the two obtained conjugates was evaluated
in xenograft models of prostate cancer. These compounds have been shown to be highly effective in inhibiting the growth of PSMA-expressing tumors.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37511087</pmid><doi>10.3390/ijms241411327</doi><orcidid>https://orcid.org/0000-0002-5302-9160</orcidid><orcidid>https://orcid.org/0000-0001-7975-0346</orcidid><orcidid>https://orcid.org/0000-0001-6796-8241</orcidid><orcidid>https://orcid.org/0000-0002-6000-6100</orcidid><orcidid>https://orcid.org/0000-0003-3442-9553</orcidid><orcidid>https://orcid.org/0000-0001-8711-6919</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2023-07, Vol.24 (14), p.11327 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10380083 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Amino acids Androgen Antagonists - therapeutic use Antiandrogens Antigens Antigens, Surface - metabolism Cancer therapies Cell Line, Tumor Comparative analysis Cytotoxins - therapeutic use Drugs Glutamate Carboxypeptidase II - metabolism Health aspects Humans Ligands Male Peptides Prostate Prostate - pathology Prostate cancer Prostatic Neoplasms - metabolism Proteins |
| title | Synthesis of Prostate-Specific Membrane Antigen-Targeted Bimodal Conjugates of Cytotoxic Agents and Antiandrogens and Their Comparative Assessment with Monoconjugates |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T17%3A33%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis%20of%20Prostate-Specific%20Membrane%20Antigen-Targeted%20Bimodal%20Conjugates%20of%20Cytotoxic%20Agents%20and%20Antiandrogens%20and%20Their%20Comparative%20Assessment%20with%20Monoconjugates&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Zyk,%20Nikolai%20Y&rft.date=2023-07-11&rft.volume=24&rft.issue=14&rft.spage=11327&rft.pages=11327-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms241411327&rft_dat=%3Cgale_pubme%3EA759152810%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2843070629&rft_id=info:pmid/37511087&rft_galeid=A759152810&rfr_iscdi=true |