Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies

The human complement system plays a crucial role in immune defense. However, its erroneous activation contributes to many serious inflammatory diseases. Since most unwanted complement effector functions result from C5 cleavage into C5a and C5b, development of C5 inhibitors, such as clinically approv...

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Veröffentlicht in:	The Journal of biological chemistry 2023-08, Vol.299 (8), p.104956-104956, Article 104956
Hauptverfasser:	Struijf, Eva M., De la O Becerra, Karla I., Ruyken, Maartje, de Haas, Carla J.C., van Oosterom, Fleur, Siere, Danique Y., van Keulen, Joanne E., Heesterbeek, Dani A.C., Dolk, Edward, Heukers, Raimond, Bardoel, Bart W., Gros, Piet, Rooijakkers, Suzan H.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	complement system inflammatory diseases inhibitor innate immunity nanobody protein structure single-domain antibody (sdAb nanobody) structural model
Online-Zugang:	Volltext
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