Neuroinvasive Flavivirus Pathogenesis Is Restricted by Host Genetic Factors in Collaborative Cross Mice, Independently of Oas1b

Powassan virus (POWV) is an emerging tick-borne flavivirus that causes neuroinvasive diseases, including encephalitis, meningitis, and paralysis. Similar to other neuroinvasive flaviviruses, such as West Nile virus (WNV) and Japanese encephalitis virus (JEV), POWV disease presentation is heterogeneo...

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Veröffentlicht in:	Journal of virology 2023-07, Vol.97 (7), p.e0071523
Hauptverfasser:	Jasperse, Brittany A, Mattocks, Melissa D, Noll, Kelsey E, Ferris, Martin T, Heise, Mark T, Lazear, Helen M
Format:	Artikel
Sprache:	eng
Schlagworte:	2',5'-Oligoadenylate Synthetase - genetics Animals Collaborative Cross Mice Disease Susceptibility Encephalitis Encephalitis Virus, Japanese - genetics Encephalitis Viruses, Tick-Borne - physiology Flavivirus - genetics Flavivirus Infections - genetics Humans Mice Paralysis Pathogenesis and Immunity West Nile virus
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