Changing protein-DNA interactions promote ORC binding-site exchange during replication origin licensing

During origin licensing, the eukaryotic replicative helicase Mcm2-7 forms head-to-head double hexamers to prime origins for bidirectional replication. Recent single-molecule and structural studies revealed that one molecule of the helicase loader ORC (origin recognition complex) can sequentially loa...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-07, Vol.120 (30), p.e2305556120-e2305556120
Hauptverfasser:	Zhang, Annie, Friedman, Larry J, Gelles, Jeff, Bell, Stephen P
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biological Sciences Cell Cycle Proteins - metabolism Deoxyribonucleic acid DNA DNA - genetics DNA - metabolism DNA biosynthesis DNA helicase DNA Replication Energy transfer Fluorescence resonance energy transfer Hexamers Intermediates Licensing Minichromosome Maintenance Proteins - metabolism Origin recognition complex Origin Recognition Complex - genetics Origin Recognition Complex - metabolism Proteins Replication Replication Origin Replication origins Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism Sliding
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