Human TLR8 induces inflammatory bone marrow erythromyeloblastic islands and anemia in SLE-prone mice

Anemia commonly occurs in systemic lupus erythematosus, a disease characterized by innate immune activation by nucleic acids. Overactivation of cytoplasmic sensors by self-DNA or RNA can cause erythroid cell death, while sparing other hematopoietic cell lineages. Whereas chronic inflammation is invo...

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Veröffentlicht in:	Life science alliance 2023-10, Vol.6 (10), p.e202302241
Hauptverfasser:	Maria, Naomi I, Papoin, Julien, Raparia, Chirag, Sun, Zeguo, Josselsohn, Rachel, Lu, Ailing, Katerji, Hani, Syeda, Mahrukh M, Polsky, David, Paulson, Robert, Kalfa, Theodosia, Barnes, Betsy J, Zhang, Weijia, Blanc, Lionel, Davidson, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia - etiology Animals Bone Marrow - metabolism Humans Lupus Erythematosus, Systemic Mice RNA Toll-Like Receptor 8
Online-Zugang:	Volltext
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