Association between Rapid Eye Movement Obstructive Sleep Apnea and Metabolic Syndrome in a Japanese Population
Objective Rapid eye movement (REM) obstructive sleep apnea (OSA) is characterized by apnea and hypopnea events due to airway collapse occurring predominantly or exclusively during REM sleep. OSA is a potential risk factor for metabolic dysfunction. However, the association between REM OSA and risk o...
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| Veröffentlicht in: | Internal Medicine 2023/07/01, Vol.62(13), pp.1907-1913 |
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| container_title | Internal Medicine |
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| creator | Mano, Mamiko Nomura, Atsuhiko Hori, Reiko Sasanabe, Ryujiro |
| description | Objective Rapid eye movement (REM) obstructive sleep apnea (OSA) is characterized by apnea and hypopnea events due to airway collapse occurring predominantly or exclusively during REM sleep. OSA is a potential risk factor for metabolic dysfunction. However, the association between REM OSA and risk of adverse health outcomes remains unclear. The present study investigated the association between REM OSA and metabolic syndrome (MetS), including the MetS components of hypertension, dyslipidemia, and hyperglycemia, in the Japanese population. Methods In total, 836 Japanese patients with mild to moderate OSA were enrolled in this study. We compared the prevalence of MetS, including hypertension, dyslipidemia, and hyperglycemia, between REM OSA and non-REM OSA via univariate analyses of descriptive statistics and logistic regression analyses. Results The prevalence of hypertension was 68.3% in the REM OSA group and 56.6% in the non-REM OSA group (p |
| doi_str_mv | 10.2169/internalmedicine.0336-22 |
| format | Article |
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OSA is a potential risk factor for metabolic dysfunction. However, the association between REM OSA and risk of adverse health outcomes remains unclear. The present study investigated the association between REM OSA and metabolic syndrome (MetS), including the MetS components of hypertension, dyslipidemia, and hyperglycemia, in the Japanese population. Methods In total, 836 Japanese patients with mild to moderate OSA were enrolled in this study. We compared the prevalence of MetS, including hypertension, dyslipidemia, and hyperglycemia, between REM OSA and non-REM OSA via univariate analyses of descriptive statistics and logistic regression analyses. Results The prevalence of hypertension was 68.3% in the REM OSA group and 56.6% in the non-REM OSA group (p<0.05). In addition, the prevalence of metabolic syndrome was significantly higher (37.0%) in the REM OSA group than in the non-REM-OSA group (25.2%). Logistic regression analyses showed that the prevalence of hypertension and MetS was significantly greater in the REM OSA group than in the non-REM-OSA group. Conclusion Our findings suggest that patients with REM OSA, regardless of age, sex, and body mass index, are at a higher risk of developing hypertension and MetS than patients with non-REM OSA.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.0336-22</identifier><identifier>PMID: 36384898</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Apnea ; Body mass index ; Dyslipidemia ; East Asian People ; Eye movements ; Humans ; Hyperglycemia ; Hypertension ; Hypertension - epidemiology ; Internal medicine ; Metabolic disorders ; Metabolic syndrome ; Metabolic Syndrome - complications ; Metabolic Syndrome - epidemiology ; Original ; Polysomnography ; rapid eye movement obstructive sleep apnea ; Regression analysis ; REM sleep ; Risk factors ; Sleep apnea ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - epidemiology ; Sleep disorders ; Sleep, REM</subject><ispartof>Internal Medicine, 2023/07/01, Vol.62(13), pp.1907-1913</ispartof><rights>2023 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2023</rights><rights>Copyright © 2023 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c668t-cacac211f9538d1aded6b742abc66efc0e03de29beca64c746737d9fa11251963</citedby><cites>FETCH-LOGICAL-c668t-cacac211f9538d1aded6b742abc66efc0e03de29beca64c746737d9fa11251963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372281/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372281/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,1884,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36384898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mano, Mamiko</creatorcontrib><creatorcontrib>Nomura, Atsuhiko</creatorcontrib><creatorcontrib>Hori, Reiko</creatorcontrib><creatorcontrib>Sasanabe, Ryujiro</creatorcontrib><title>Association between Rapid Eye Movement Obstructive Sleep Apnea and Metabolic Syndrome in a Japanese Population</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Objective Rapid eye movement (REM) obstructive sleep apnea (OSA) is characterized by apnea and hypopnea events due to airway collapse occurring predominantly or exclusively during REM sleep. OSA is a potential risk factor for metabolic dysfunction. However, the association between REM OSA and risk of adverse health outcomes remains unclear. The present study investigated the association between REM OSA and metabolic syndrome (MetS), including the MetS components of hypertension, dyslipidemia, and hyperglycemia, in the Japanese population. Methods In total, 836 Japanese patients with mild to moderate OSA were enrolled in this study. We compared the prevalence of MetS, including hypertension, dyslipidemia, and hyperglycemia, between REM OSA and non-REM OSA via univariate analyses of descriptive statistics and logistic regression analyses. Results The prevalence of hypertension was 68.3% in the REM OSA group and 56.6% in the non-REM OSA group (p<0.05). In addition, the prevalence of metabolic syndrome was significantly higher (37.0%) in the REM OSA group than in the non-REM-OSA group (25.2%). Logistic regression analyses showed that the prevalence of hypertension and MetS was significantly greater in the REM OSA group than in the non-REM-OSA group. Conclusion Our findings suggest that patients with REM OSA, regardless of age, sex, and body mass index, are at a higher risk of developing hypertension and MetS than patients with non-REM OSA.</description><subject>Apnea</subject><subject>Body mass index</subject><subject>Dyslipidemia</subject><subject>East Asian People</subject><subject>Eye movements</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Hypertension</subject><subject>Hypertension - epidemiology</subject><subject>Internal medicine</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - complications</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Original</subject><subject>Polysomnography</subject><subject>rapid eye movement obstructive sleep apnea</subject><subject>Regression analysis</subject><subject>REM sleep</subject><subject>Risk factors</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - epidemiology</subject><subject>Sleep disorders</subject><subject>Sleep, REM</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkU9v1DAQxS0EokvhKyBLXLikxHbWcU5oVbX8UatFFM7WxJltvUrsYDuL9tvjsMsKiiyND_Ob9zx-hFBWXnAmm3fWJQwO-gE7a6zDi1IIWXD-hCyYqJqi5mL5lCzKhqmC53JGXsS4LUuh6oY_J2dCClWpRi2IW8XojYVkvaMtpp-Ijn6F0Xb0ao_01u9wQJfouo0pTCbZHdK7HnGkq9EhUHAdvcUEre-toXd71wU_ILWOAv0MIziMSL_4cep_W7wkzzbQR3x1vM_J9-urb5cfi5v1h0-Xq5vCSKlSYSAfztimWQrVMeiwk21dcWhzHzemxFJ0yJsWDcjK1JWsRd01G2CML1kjxTl5f9AdpzZ_kskrBOj1GOwAYa89WP1vx9kHfe93mpWi5lyxrPD2qBD8jwlj0oONBvs-r-SnqHl2rGQlKpXRN4_QrZ_meDKlstxSVIJnSh0oE3yMATen17BSz6nqx6nqOVXN59HXf29zGvwTYwbWB2AbE9zjCYCQrOnxf2XJNRNzPVqcSPMAQaMTvwDAx8M-</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Mano, Mamiko</creator><creator>Nomura, Atsuhiko</creator><creator>Hori, Reiko</creator><creator>Sasanabe, Ryujiro</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230701</creationdate><title>Association between Rapid Eye Movement Obstructive Sleep Apnea and Metabolic Syndrome in a Japanese Population</title><author>Mano, Mamiko ; Nomura, Atsuhiko ; Hori, Reiko ; Sasanabe, Ryujiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c668t-cacac211f9538d1aded6b742abc66efc0e03de29beca64c746737d9fa11251963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Apnea</topic><topic>Body mass index</topic><topic>Dyslipidemia</topic><topic>East Asian People</topic><topic>Eye movements</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Hypertension</topic><topic>Hypertension - epidemiology</topic><topic>Internal medicine</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - complications</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Original</topic><topic>Polysomnography</topic><topic>rapid eye movement obstructive sleep apnea</topic><topic>Regression analysis</topic><topic>REM sleep</topic><topic>Risk factors</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep Apnea, Obstructive - epidemiology</topic><topic>Sleep disorders</topic><topic>Sleep, REM</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mano, Mamiko</creatorcontrib><creatorcontrib>Nomura, Atsuhiko</creatorcontrib><creatorcontrib>Hori, Reiko</creatorcontrib><creatorcontrib>Sasanabe, Ryujiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mano, Mamiko</au><au>Nomura, Atsuhiko</au><au>Hori, Reiko</au><au>Sasanabe, Ryujiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between Rapid Eye Movement Obstructive Sleep Apnea and Metabolic Syndrome in a Japanese Population</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>62</volume><issue>13</issue><spage>1907</spage><epage>1913</epage><pages>1907-1913</pages><artnum>0336-22</artnum><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>Objective Rapid eye movement (REM) obstructive sleep apnea (OSA) is characterized by apnea and hypopnea events due to airway collapse occurring predominantly or exclusively during REM sleep. OSA is a potential risk factor for metabolic dysfunction. However, the association between REM OSA and risk of adverse health outcomes remains unclear. The present study investigated the association between REM OSA and metabolic syndrome (MetS), including the MetS components of hypertension, dyslipidemia, and hyperglycemia, in the Japanese population. Methods In total, 836 Japanese patients with mild to moderate OSA were enrolled in this study. We compared the prevalence of MetS, including hypertension, dyslipidemia, and hyperglycemia, between REM OSA and non-REM OSA via univariate analyses of descriptive statistics and logistic regression analyses. Results The prevalence of hypertension was 68.3% in the REM OSA group and 56.6% in the non-REM OSA group (p<0.05). In addition, the prevalence of metabolic syndrome was significantly higher (37.0%) in the REM OSA group than in the non-REM-OSA group (25.2%). Logistic regression analyses showed that the prevalence of hypertension and MetS was significantly greater in the REM OSA group than in the non-REM-OSA group. Conclusion Our findings suggest that patients with REM OSA, regardless of age, sex, and body mass index, are at a higher risk of developing hypertension and MetS than patients with non-REM OSA.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>36384898</pmid><doi>10.2169/internalmedicine.0336-22</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Apnea Body mass index Dyslipidemia East Asian People Eye movements Humans Hyperglycemia Hypertension Hypertension - epidemiology Internal medicine Metabolic disorders Metabolic syndrome Metabolic Syndrome - complications Metabolic Syndrome - epidemiology Original Polysomnography rapid eye movement obstructive sleep apnea Regression analysis REM sleep Risk factors Sleep apnea Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - epidemiology Sleep disorders Sleep, REM |
| title | Association between Rapid Eye Movement Obstructive Sleep Apnea and Metabolic Syndrome in a Japanese Population |
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