Resveratrol can induce differentiating phenotypes in canine oral mucosal melanoma cells

This report described the differentiation induction of canine oral mucosal melanoma (OMM) cells by resveratrol. Exposure of canine OMM cells to resveratrol (maximum dose: 50 μM and treatment period: 72 hr) induced differentiating features like melanocytes, and enhanced chemosensitivity against cispl...

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Veröffentlicht in:	Journal of Veterinary Medical Science 2023, Vol.85(7), pp.721-726
Hauptverfasser:	FUKUOKA, Nana, ISHIDA, Tatsuya, ISHII, Kyota, SATO, Ayami, DAGLI, Maria Lucia Zaidan, VIRGONA, Nantiga, YANO, Tomohiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals c-Jun N-terminal kinase c-Jun protein canine oral mucosal melanoma cell Cell activation Cell differentiation Cell viability Cisplatin Dog Diseases - drug therapy Dogs Gene expression JNK protein MAP kinase MAP Kinase Signaling System Melanocytes Melanoma Melanoma - drug therapy Melanoma - veterinary Microphthalmia-associated transcription factor Mitogen-Activated Protein Kinases - metabolism Mucosa Pharmacology Phenotypes Resveratrol Resveratrol - pharmacology RNA, Messenger - metabolism Transcription factors
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