Retinal sensitivity and gaze fixation evaluated by microperimetry in subjects with type 2 diabetes: two independent parameters that explore different neuronal circuits
Background and aims Retinal sensitivity (RS) and gaze fixation (GF) assessed by retinal microperimetry are useful and complementary tools for identifying mild cognitive impairment (MCI) in patients with type 2 diabetes (T2D). The hypothesis is that RS and GF examine different neural circuits: RS dep...
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| Veröffentlicht in: | Journal of endocrinological investigation 2023-09, Vol.46 (9), p.1875-1880 |
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| creator | Ortiz-Zuñiga, A. M. Rojano Toimil, A. Rahnama, K. Lainez, E. Raguer, N. Simó-Servat, O. Hernández, C. Simó, R. Ciudin, A. |
| description | Background and aims
Retinal sensitivity (RS) and gaze fixation (GF) assessed by retinal microperimetry are useful and complementary tools for identifying mild cognitive impairment (MCI) in patients with type 2 diabetes (T2D). The hypothesis is that RS and GF examine different neural circuits: RS depends only on the visual pathway while GF reflects white matter complex connectivity networks. The aim of the study is to shed light to this issue by examining the relationship of these two parameters with visual evoked potentials (VEP), the current gold standard to examine the visual pathway.
Materials and methods
Consecutive T2D patients > 65 years were recruited from the outpatient clinic. Retinal microperimetry (MAIA 3rd generation) and visual evoked potentials (VEP) (Nicolet Viking ED). RS (dB), GF (BCEA63%, BCEA95%) (MAIA) and VEP (Latency P100ms, Amplitude75–100 uV) were analyzed.
Results
Thirty three patients (45% women, 72.1 ± 4.6 years) were included. VEP parameters significantly correlated with RS but not with GF.
Conclusions
These results confirm that RS but not GF depends on the visual pathway, reinforcing the concept that they are complementary diagnostic tools. Used together can further increase the value of microperimetry as screening test for identifying T2D population with cognitive impairment. |
| doi_str_mv | 10.1007/s40618-023-02046-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10371889</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2783490899</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-62a0616e9aa321bd6034f31f199d88d489e4149c5fb5ae565cd5985c9e01cbd13</originalsourceid><addsrcrecordid>eNp9kk1v1DAQhiMEoqXwBzggS1y4BOzYTmwuqKr4kipVquBsOfZk16usHWxn2_CH-Jt4u6UUDj34Q5rnHc87nqp6SfBbgnH3LjHcElHjhpaFWVsvj6pj0jW4FlS0j-_dj6pnKW0wph0V3dPqiLaiw5jw4-rXJWTn9YgS-OSy27m8IO0tWumfgAZ3rbMLHsFOj7POYFG_oK0zMUwQ3RZyXJDzKM39BkxO6MrlNcrLBKhB1ukeMqT3KF-FQlmYoGw-o0lHXbQQE8prnRFcT2OIUBTDAHFPeJhj2JdlXDSzy-l59WTQY4IXt-dJ9f3Tx29nX-rzi89fz07Pa8M6nuu20aUnLUitaUN622LKBkoGIqUVwjIhgREmDR96roG33FguBTcSMDG9JfSk-nDIO839FqwpxUQ9qqmY1XFRQTv1b8S7tVqFnSKluUQIWTK8uc0Qw48ZUlZblwyMo_YQ5qSaTlAmsZB79PV_6CbMsdgulGANZ6yYKlRzoErXU4ow3FVDsNoPgjoMgiqDoG4GQS1F9Oq-jzvJn58vAD0AqYT8CuLftx9I-xuccMSA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2842544475</pqid></control><display><type>article</type><title>Retinal sensitivity and gaze fixation evaluated by microperimetry in subjects with type 2 diabetes: two independent parameters that explore different neuronal circuits</title><source>SpringerNature Journals</source><creator>Ortiz-Zuñiga, A. M. ; Rojano Toimil, A. ; Rahnama, K. ; Lainez, E. ; Raguer, N. ; Simó-Servat, O. ; Hernández, C. ; Simó, R. ; Ciudin, A.</creator><creatorcontrib>Ortiz-Zuñiga, A. M. ; Rojano Toimil, A. ; Rahnama, K. ; Lainez, E. ; Raguer, N. ; Simó-Servat, O. ; Hernández, C. ; Simó, R. ; Ciudin, A.</creatorcontrib><description>Background and aims
Retinal sensitivity (RS) and gaze fixation (GF) assessed by retinal microperimetry are useful and complementary tools for identifying mild cognitive impairment (MCI) in patients with type 2 diabetes (T2D). The hypothesis is that RS and GF examine different neural circuits: RS depends only on the visual pathway while GF reflects white matter complex connectivity networks. The aim of the study is to shed light to this issue by examining the relationship of these two parameters with visual evoked potentials (VEP), the current gold standard to examine the visual pathway.
Materials and methods
Consecutive T2D patients > 65 years were recruited from the outpatient clinic. Retinal microperimetry (MAIA 3rd generation) and visual evoked potentials (VEP) (Nicolet Viking ED). RS (dB), GF (BCEA63%, BCEA95%) (MAIA) and VEP (Latency P100ms, Amplitude75–100 uV) were analyzed.
Results
Thirty three patients (45% women, 72.1 ± 4.6 years) were included. VEP parameters significantly correlated with RS but not with GF.
Conclusions
These results confirm that RS but not GF depends on the visual pathway, reinforcing the concept that they are complementary diagnostic tools. Used together can further increase the value of microperimetry as screening test for identifying T2D population with cognitive impairment.</description><identifier>ISSN: 1720-8386</identifier><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/s40618-023-02046-y</identifier><identifier>PMID: 36870015</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Cognitive ability ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Endocrinology ; Internal Medicine ; Latency ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Neural networks ; Original ; Original Article ; Retina ; Substantia alba ; Visual evoked potentials ; Visual pathways</subject><ispartof>Journal of endocrinological investigation, 2023-09, Vol.46 (9), p.1875-1880</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-62a0616e9aa321bd6034f31f199d88d489e4149c5fb5ae565cd5985c9e01cbd13</citedby><cites>FETCH-LOGICAL-c475t-62a0616e9aa321bd6034f31f199d88d489e4149c5fb5ae565cd5985c9e01cbd13</cites><orcidid>0000-0003-0475-3096 ; 0000-0001-5622-0203</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40618-023-02046-y$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40618-023-02046-y$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36870015$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ortiz-Zuñiga, A. M.</creatorcontrib><creatorcontrib>Rojano Toimil, A.</creatorcontrib><creatorcontrib>Rahnama, K.</creatorcontrib><creatorcontrib>Lainez, E.</creatorcontrib><creatorcontrib>Raguer, N.</creatorcontrib><creatorcontrib>Simó-Servat, O.</creatorcontrib><creatorcontrib>Hernández, C.</creatorcontrib><creatorcontrib>Simó, R.</creatorcontrib><creatorcontrib>Ciudin, A.</creatorcontrib><title>Retinal sensitivity and gaze fixation evaluated by microperimetry in subjects with type 2 diabetes: two independent parameters that explore different neuronal circuits</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><addtitle>J Endocrinol Invest</addtitle><description>Background and aims
Retinal sensitivity (RS) and gaze fixation (GF) assessed by retinal microperimetry are useful and complementary tools for identifying mild cognitive impairment (MCI) in patients with type 2 diabetes (T2D). The hypothesis is that RS and GF examine different neural circuits: RS depends only on the visual pathway while GF reflects white matter complex connectivity networks. The aim of the study is to shed light to this issue by examining the relationship of these two parameters with visual evoked potentials (VEP), the current gold standard to examine the visual pathway.
Materials and methods
Consecutive T2D patients > 65 years were recruited from the outpatient clinic. Retinal microperimetry (MAIA 3rd generation) and visual evoked potentials (VEP) (Nicolet Viking ED). RS (dB), GF (BCEA63%, BCEA95%) (MAIA) and VEP (Latency P100ms, Amplitude75–100 uV) were analyzed.
Results
Thirty three patients (45% women, 72.1 ± 4.6 years) were included. VEP parameters significantly correlated with RS but not with GF.
Conclusions
These results confirm that RS but not GF depends on the visual pathway, reinforcing the concept that they are complementary diagnostic tools. Used together can further increase the value of microperimetry as screening test for identifying T2D population with cognitive impairment.</description><subject>Cognitive ability</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Endocrinology</subject><subject>Internal Medicine</subject><subject>Latency</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Neural networks</subject><subject>Original</subject><subject>Original Article</subject><subject>Retina</subject><subject>Substantia alba</subject><subject>Visual evoked potentials</subject><subject>Visual pathways</subject><issn>1720-8386</issn><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kk1v1DAQhiMEoqXwBzggS1y4BOzYTmwuqKr4kipVquBsOfZk16usHWxn2_CH-Jt4u6UUDj34Q5rnHc87nqp6SfBbgnH3LjHcElHjhpaFWVsvj6pj0jW4FlS0j-_dj6pnKW0wph0V3dPqiLaiw5jw4-rXJWTn9YgS-OSy27m8IO0tWumfgAZ3rbMLHsFOj7POYFG_oK0zMUwQ3RZyXJDzKM39BkxO6MrlNcrLBKhB1ukeMqT3KF-FQlmYoGw-o0lHXbQQE8prnRFcT2OIUBTDAHFPeJhj2JdlXDSzy-l59WTQY4IXt-dJ9f3Tx29nX-rzi89fz07Pa8M6nuu20aUnLUitaUN622LKBkoGIqUVwjIhgREmDR96roG33FguBTcSMDG9JfSk-nDIO839FqwpxUQ9qqmY1XFRQTv1b8S7tVqFnSKluUQIWTK8uc0Qw48ZUlZblwyMo_YQ5qSaTlAmsZB79PV_6CbMsdgulGANZ6yYKlRzoErXU4ow3FVDsNoPgjoMgiqDoG4GQS1F9Oq-jzvJn58vAD0AqYT8CuLftx9I-xuccMSA</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Ortiz-Zuñiga, A. M.</creator><creator>Rojano Toimil, A.</creator><creator>Rahnama, K.</creator><creator>Lainez, E.</creator><creator>Raguer, N.</creator><creator>Simó-Servat, O.</creator><creator>Hernández, C.</creator><creator>Simó, R.</creator><creator>Ciudin, A.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0475-3096</orcidid><orcidid>https://orcid.org/0000-0001-5622-0203</orcidid></search><sort><creationdate>20230901</creationdate><title>Retinal sensitivity and gaze fixation evaluated by microperimetry in subjects with type 2 diabetes: two independent parameters that explore different neuronal circuits</title><author>Ortiz-Zuñiga, A. M. ; Rojano Toimil, A. ; Rahnama, K. ; Lainez, E. ; Raguer, N. ; Simó-Servat, O. ; Hernández, C. ; Simó, R. ; Ciudin, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-62a0616e9aa321bd6034f31f199d88d489e4149c5fb5ae565cd5985c9e01cbd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cognitive ability</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Endocrinology</topic><topic>Internal Medicine</topic><topic>Latency</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Neural networks</topic><topic>Original</topic><topic>Original Article</topic><topic>Retina</topic><topic>Substantia alba</topic><topic>Visual evoked potentials</topic><topic>Visual pathways</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ortiz-Zuñiga, A. M.</creatorcontrib><creatorcontrib>Rojano Toimil, A.</creatorcontrib><creatorcontrib>Rahnama, K.</creatorcontrib><creatorcontrib>Lainez, E.</creatorcontrib><creatorcontrib>Raguer, N.</creatorcontrib><creatorcontrib>Simó-Servat, O.</creatorcontrib><creatorcontrib>Hernández, C.</creatorcontrib><creatorcontrib>Simó, R.</creatorcontrib><creatorcontrib>Ciudin, A.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ortiz-Zuñiga, A. M.</au><au>Rojano Toimil, A.</au><au>Rahnama, K.</au><au>Lainez, E.</au><au>Raguer, N.</au><au>Simó-Servat, O.</au><au>Hernández, C.</au><au>Simó, R.</au><au>Ciudin, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinal sensitivity and gaze fixation evaluated by microperimetry in subjects with type 2 diabetes: two independent parameters that explore different neuronal circuits</atitle><jtitle>Journal of endocrinological investigation</jtitle><stitle>J Endocrinol Invest</stitle><addtitle>J Endocrinol Invest</addtitle><date>2023-09-01</date><risdate>2023</risdate><volume>46</volume><issue>9</issue><spage>1875</spage><epage>1880</epage><pages>1875-1880</pages><issn>1720-8386</issn><issn>0391-4097</issn><eissn>1720-8386</eissn><abstract>Background and aims
Retinal sensitivity (RS) and gaze fixation (GF) assessed by retinal microperimetry are useful and complementary tools for identifying mild cognitive impairment (MCI) in patients with type 2 diabetes (T2D). The hypothesis is that RS and GF examine different neural circuits: RS depends only on the visual pathway while GF reflects white matter complex connectivity networks. The aim of the study is to shed light to this issue by examining the relationship of these two parameters with visual evoked potentials (VEP), the current gold standard to examine the visual pathway.
Materials and methods
Consecutive T2D patients > 65 years were recruited from the outpatient clinic. Retinal microperimetry (MAIA 3rd generation) and visual evoked potentials (VEP) (Nicolet Viking ED). RS (dB), GF (BCEA63%, BCEA95%) (MAIA) and VEP (Latency P100ms, Amplitude75–100 uV) were analyzed.
Results
Thirty three patients (45% women, 72.1 ± 4.6 years) were included. VEP parameters significantly correlated with RS but not with GF.
Conclusions
These results confirm that RS but not GF depends on the visual pathway, reinforcing the concept that they are complementary diagnostic tools. Used together can further increase the value of microperimetry as screening test for identifying T2D population with cognitive impairment.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>36870015</pmid><doi>10.1007/s40618-023-02046-y</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0475-3096</orcidid><orcidid>https://orcid.org/0000-0001-5622-0203</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of endocrinological investigation, 2023-09, Vol.46 (9), p.1875-1880 |
| issn | 1720-8386 0391-4097 1720-8386 |
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| subjects | Cognitive ability Diabetes Diabetes mellitus (non-insulin dependent) Endocrinology Internal Medicine Latency Medicine Medicine & Public Health Metabolic Diseases Neural networks Original Original Article Retina Substantia alba Visual evoked potentials Visual pathways |
| title | Retinal sensitivity and gaze fixation evaluated by microperimetry in subjects with type 2 diabetes: two independent parameters that explore different neuronal circuits |
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