A Case of Immune-Mediated Pneumonitis Associated With Dual Nivolumab and Ipilimumab Immunotherapy Treatment

Nivolumab and ipilimumab are immunotherapy agents used in combination to treat metastatic melanoma and have proven to be efficacious. However, they have been linked to the development of immune-mediated inflammatory processes in various organ systems and tissues, including immune-mediated pneumoniti...

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Veröffentlicht in:Curēus (Palo Alto, CA) CA), 2023-06, Vol.15 (6), p.e40792
Hauptverfasser: Al-Saghir, Tala, Suleiman, Noor, Goodman, Benjamin D, Ferguson, Michael W, Tejwani, Sheela
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creator Al-Saghir, Tala
Suleiman, Noor
Goodman, Benjamin D
Ferguson, Michael W
Tejwani, Sheela
description Nivolumab and ipilimumab are immunotherapy agents used in combination to treat metastatic melanoma and have proven to be efficacious. However, they have been linked to the development of immune-mediated inflammatory processes in various organ systems and tissues, including immune-mediated pneumonitis (IMP). This case report describes a 50-year-old female patient with metastatic melanoma who was treated with nivolumab and ipilimumab therapy and developed IMP as a complication. Despite treatment with steroids and infliximab, the patient's condition worsened, and she passed away due to respiratory compromise. This report emphasizes the potential for serious complications in patients receiving combination immunotherapy and highlights the importance of close monitoring and risk stratification, particularly in patients with underlying lung conditions.
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subjects Case reports
Chronic obstructive pulmonary disease
Hospitals
Immunotherapy
Internal Medicine
Lung cancer
Lung diseases
Melanoma
Metastasis
Monoclonal antibodies
Mortality
Oncology
Patients
Pleural effusion
Pulmonology
Quality of life
Skin cancer
Sleep apnea
Steroids
title A Case of Immune-Mediated Pneumonitis Associated With Dual Nivolumab and Ipilimumab Immunotherapy Treatment
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