Prevalence of tuberculosis/COVID-19 co-infection and factors associated with SARS-CoV-2 infection in pulmonary tuberculosis patients at a respiratory diseases center: a cross-sectional study
currently, tuberculosis (TB) is the second cause of infectious disease-related deaths before COVID-19. These two infections have several similarities but little data is available on TB/COVID-19 co-infection, hence, we sought to investigate the prevalence of this co-infection and the factors associat...
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| Veröffentlicht in: | The Pan African medical journal 2023, Vol.44, p.204-204 |
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| creator | Mangamba, Laurent-Mireille Endale Sike, Christiane Ingrid Medi Tochie, Joël Noutakdie Dalle, Grace Ngondi Nkouagmi, Nadia Balkissou, Adamou Dodo Bille, Bernard Eyoum Ngahane, Bertrand Hugo Mbatchou Moukoko, Carole Else Eboumbou |
| description | currently, tuberculosis (TB) is the second cause of infectious disease-related deaths before COVID-19. These two infections have several similarities but little data is available on TB/COVID-19 co-infection, hence, we sought to investigate the prevalence of this co-infection and the factors associated with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in tuberculosis patients in a tuberculosis-endemic area.
we conducted a prospective cross-sectional study from January to June 2022 at Respiratory Diseases Center in Douala, Cameroon by enrolling all consenting pulmonary tuberculosis patients. The presence of SARS-CoV-2 ribonucleic acid (RNA) and gamma-interferon levels were laboratory analyzed using the Reverse Transcriptase-Polymerase Chain Reaction and the enzyme-linked immunosorbent assay (ELISA) technique, respectively. The factors associated with COVID-19 carriage in pulmonary tuberculosis patients were analyzed by logistic regressions.
overall, we enrolled 185 patients; 57.8% were males (sex ratio of 1.36) and their mean age was 43.70 ± 17.89 years. The prevalence of SARS-CoV-2 RNA in pulmonary TB patients was 24.3%. Asthma and sore throat were the factors favoring carriage (OR=3.74; 95% CI=1.271-11.017; p=0.017 and OR=4.05; 95%CI=1.204-13.600; p=0.024) and cough was a protective factor (OR=0.15; 95% CI = 0.034-0.690; p=0.015).
the prevalence of SARS-CoV-2 carriage in tuberculosis patients is high and greater than the national prevalence. Asthma and sore throat would be associated factors. |
| doi_str_mv | 10.11604/pamj.2023.44.204.38541 |
| format | Article |
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we conducted a prospective cross-sectional study from January to June 2022 at Respiratory Diseases Center in Douala, Cameroon by enrolling all consenting pulmonary tuberculosis patients. The presence of SARS-CoV-2 ribonucleic acid (RNA) and gamma-interferon levels were laboratory analyzed using the Reverse Transcriptase-Polymerase Chain Reaction and the enzyme-linked immunosorbent assay (ELISA) technique, respectively. The factors associated with COVID-19 carriage in pulmonary tuberculosis patients were analyzed by logistic regressions.
overall, we enrolled 185 patients; 57.8% were males (sex ratio of 1.36) and their mean age was 43.70 ± 17.89 years. The prevalence of SARS-CoV-2 RNA in pulmonary TB patients was 24.3%. Asthma and sore throat were the factors favoring carriage (OR=3.74; 95% CI=1.271-11.017; p=0.017 and OR=4.05; 95%CI=1.204-13.600; p=0.024) and cough was a protective factor (OR=0.15; 95% CI = 0.034-0.690; p=0.015).
the prevalence of SARS-CoV-2 carriage in tuberculosis patients is high and greater than the national prevalence. Asthma and sore throat would be associated factors.</description><identifier>ISSN: 1937-8688</identifier><identifier>EISSN: 1937-8688</identifier><identifier>DOI: 10.11604/pamj.2023.44.204.38541</identifier><identifier>PMID: 37484595</identifier><language>eng</language><publisher>Uganda: The African Field Epidemiology Network</publisher><subject>Adult ; Asthma ; Cameroon - epidemiology ; Coinfection - epidemiology ; COVID-19 - epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Pharyngitis ; Prevalence ; Prospective Studies ; RNA, Viral ; SARS-CoV-2 ; Tuberculosis - epidemiology ; Tuberculosis, Pulmonary - epidemiology</subject><ispartof>The Pan African medical journal, 2023, Vol.44, p.204-204</ispartof><rights>Copyright: Laurent-Mireille Endale Mangamba et al.</rights><rights>Laurent-Mireille Endale Mangamba et al. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-be6ac71f02ec95284e393bdb70dbc7e04e750396c9c6e69a7290b1024be1c1cc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362651/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362651/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37484595$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mangamba, Laurent-Mireille Endale</creatorcontrib><creatorcontrib>Sike, Christiane Ingrid Medi</creatorcontrib><creatorcontrib>Tochie, Joël Noutakdie</creatorcontrib><creatorcontrib>Dalle, Grace Ngondi</creatorcontrib><creatorcontrib>Nkouagmi, Nadia</creatorcontrib><creatorcontrib>Balkissou, Adamou Dodo</creatorcontrib><creatorcontrib>Bille, Bernard Eyoum</creatorcontrib><creatorcontrib>Ngahane, Bertrand Hugo Mbatchou</creatorcontrib><creatorcontrib>Moukoko, Carole Else Eboumbou</creatorcontrib><title>Prevalence of tuberculosis/COVID-19 co-infection and factors associated with SARS-CoV-2 infection in pulmonary tuberculosis patients at a respiratory diseases center: a cross-sectional study</title><title>The Pan African medical journal</title><addtitle>Pan Afr Med J</addtitle><description>currently, tuberculosis (TB) is the second cause of infectious disease-related deaths before COVID-19. These two infections have several similarities but little data is available on TB/COVID-19 co-infection, hence, we sought to investigate the prevalence of this co-infection and the factors associated with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in tuberculosis patients in a tuberculosis-endemic area.
we conducted a prospective cross-sectional study from January to June 2022 at Respiratory Diseases Center in Douala, Cameroon by enrolling all consenting pulmonary tuberculosis patients. The presence of SARS-CoV-2 ribonucleic acid (RNA) and gamma-interferon levels were laboratory analyzed using the Reverse Transcriptase-Polymerase Chain Reaction and the enzyme-linked immunosorbent assay (ELISA) technique, respectively. The factors associated with COVID-19 carriage in pulmonary tuberculosis patients were analyzed by logistic regressions.
overall, we enrolled 185 patients; 57.8% were males (sex ratio of 1.36) and their mean age was 43.70 ± 17.89 years. The prevalence of SARS-CoV-2 RNA in pulmonary TB patients was 24.3%. Asthma and sore throat were the factors favoring carriage (OR=3.74; 95% CI=1.271-11.017; p=0.017 and OR=4.05; 95%CI=1.204-13.600; p=0.024) and cough was a protective factor (OR=0.15; 95% CI = 0.034-0.690; p=0.015).
the prevalence of SARS-CoV-2 carriage in tuberculosis patients is high and greater than the national prevalence. Asthma and sore throat would be associated factors.</description><subject>Adult</subject><subject>Asthma</subject><subject>Cameroon - epidemiology</subject><subject>Coinfection - epidemiology</subject><subject>COVID-19 - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pharyngitis</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>RNA, Viral</subject><subject>SARS-CoV-2</subject><subject>Tuberculosis - epidemiology</subject><subject>Tuberculosis, Pulmonary - epidemiology</subject><issn>1937-8688</issn><issn>1937-8688</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUV1v1DAQjBCIfsBfAD_ykqsdO47NC6oOCpUqFVHoq-U4G-oqiYPXKbo_x2_Dd1dK-zQrzc7srKYo3jK6YkxScTLb8XZV0YqvhMgoVlzVgj0rDpnmTamkUs8fzQfFEeItpVIqTl8WB7wRStS6Piz-fI1wZweYHJDQk7S0EN0yBPR4sr68Pv9YMk1cKP3Ug0s-TMROHemtSyEisYjBeZugI799uiFXp9-uynW4LivyX-AnMi_DGCYbN08OkNkmD1PKPolYEgFnH2023pDOI1gEJC7zEN9n2sWAWOLe1A4E09JtXhUvejsgvL7H4-LH2afv6y_lxeXn8_XpRekEU6lsQVrXsJ5W4HRdKQFc87ZrG9q1rgEqoKkp19JpJ0Fq21SatoxWogXmmHP8uPiw952XdoRumyrawczRj_krE6w3T5nJ35if4c4wymUla5Yd3t07xPBrAUxm9OhgGOwEYUGTQzFBqVIyrzb71d3LEfqHO4yaXf1mW7_Z1m-EyCjMrv6sfPM45oPuX9_8L_NPsqY</recordid><startdate>2023</startdate><enddate>2023</enddate><creator>Mangamba, Laurent-Mireille Endale</creator><creator>Sike, Christiane Ingrid Medi</creator><creator>Tochie, Joël Noutakdie</creator><creator>Dalle, Grace Ngondi</creator><creator>Nkouagmi, Nadia</creator><creator>Balkissou, Adamou Dodo</creator><creator>Bille, Bernard Eyoum</creator><creator>Ngahane, Bertrand Hugo Mbatchou</creator><creator>Moukoko, Carole Else Eboumbou</creator><general>The African Field Epidemiology Network</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2023</creationdate><title>Prevalence of tuberculosis/COVID-19 co-infection and factors associated with SARS-CoV-2 infection in pulmonary tuberculosis patients at a respiratory diseases center: a cross-sectional study</title><author>Mangamba, Laurent-Mireille Endale ; Sike, Christiane Ingrid Medi ; Tochie, Joël Noutakdie ; Dalle, Grace Ngondi ; Nkouagmi, Nadia ; Balkissou, Adamou Dodo ; Bille, Bernard Eyoum ; Ngahane, Bertrand Hugo Mbatchou ; Moukoko, Carole Else Eboumbou</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-be6ac71f02ec95284e393bdb70dbc7e04e750396c9c6e69a7290b1024be1c1cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Asthma</topic><topic>Cameroon - epidemiology</topic><topic>Coinfection - epidemiology</topic><topic>COVID-19 - epidemiology</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pharyngitis</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>RNA, Viral</topic><topic>SARS-CoV-2</topic><topic>Tuberculosis - epidemiology</topic><topic>Tuberculosis, Pulmonary - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mangamba, Laurent-Mireille Endale</creatorcontrib><creatorcontrib>Sike, Christiane Ingrid Medi</creatorcontrib><creatorcontrib>Tochie, Joël Noutakdie</creatorcontrib><creatorcontrib>Dalle, Grace Ngondi</creatorcontrib><creatorcontrib>Nkouagmi, Nadia</creatorcontrib><creatorcontrib>Balkissou, Adamou Dodo</creatorcontrib><creatorcontrib>Bille, Bernard Eyoum</creatorcontrib><creatorcontrib>Ngahane, Bertrand Hugo Mbatchou</creatorcontrib><creatorcontrib>Moukoko, Carole Else Eboumbou</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Pan African medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mangamba, Laurent-Mireille Endale</au><au>Sike, Christiane Ingrid Medi</au><au>Tochie, Joël Noutakdie</au><au>Dalle, Grace Ngondi</au><au>Nkouagmi, Nadia</au><au>Balkissou, Adamou Dodo</au><au>Bille, Bernard Eyoum</au><au>Ngahane, Bertrand Hugo Mbatchou</au><au>Moukoko, Carole Else Eboumbou</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of tuberculosis/COVID-19 co-infection and factors associated with SARS-CoV-2 infection in pulmonary tuberculosis patients at a respiratory diseases center: a cross-sectional study</atitle><jtitle>The Pan African medical journal</jtitle><addtitle>Pan Afr Med J</addtitle><date>2023</date><risdate>2023</risdate><volume>44</volume><spage>204</spage><epage>204</epage><pages>204-204</pages><issn>1937-8688</issn><eissn>1937-8688</eissn><abstract>currently, tuberculosis (TB) is the second cause of infectious disease-related deaths before COVID-19. These two infections have several similarities but little data is available on TB/COVID-19 co-infection, hence, we sought to investigate the prevalence of this co-infection and the factors associated with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in tuberculosis patients in a tuberculosis-endemic area.
we conducted a prospective cross-sectional study from January to June 2022 at Respiratory Diseases Center in Douala, Cameroon by enrolling all consenting pulmonary tuberculosis patients. The presence of SARS-CoV-2 ribonucleic acid (RNA) and gamma-interferon levels were laboratory analyzed using the Reverse Transcriptase-Polymerase Chain Reaction and the enzyme-linked immunosorbent assay (ELISA) technique, respectively. The factors associated with COVID-19 carriage in pulmonary tuberculosis patients were analyzed by logistic regressions.
overall, we enrolled 185 patients; 57.8% were males (sex ratio of 1.36) and their mean age was 43.70 ± 17.89 years. The prevalence of SARS-CoV-2 RNA in pulmonary TB patients was 24.3%. Asthma and sore throat were the factors favoring carriage (OR=3.74; 95% CI=1.271-11.017; p=0.017 and OR=4.05; 95%CI=1.204-13.600; p=0.024) and cough was a protective factor (OR=0.15; 95% CI = 0.034-0.690; p=0.015).
the prevalence of SARS-CoV-2 carriage in tuberculosis patients is high and greater than the national prevalence. Asthma and sore throat would be associated factors.</abstract><cop>Uganda</cop><pub>The African Field Epidemiology Network</pub><pmid>37484595</pmid><doi>10.11604/pamj.2023.44.204.38541</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1937-8688 |
| ispartof | The Pan African medical journal, 2023, Vol.44, p.204-204 |
| issn | 1937-8688 1937-8688 |
| language | eng |
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| source | African Journals Online (Open Access); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Adult Asthma Cameroon - epidemiology Coinfection - epidemiology COVID-19 - epidemiology Cross-Sectional Studies Female Humans Male Middle Aged Pharyngitis Prevalence Prospective Studies RNA, Viral SARS-CoV-2 Tuberculosis - epidemiology Tuberculosis, Pulmonary - epidemiology |
| title | Prevalence of tuberculosis/COVID-19 co-infection and factors associated with SARS-CoV-2 infection in pulmonary tuberculosis patients at a respiratory diseases center: a cross-sectional study |
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