Augmenting TCR signal strength and ICOS costimulation results in metabolically fit and therapeutically potent human CAR Th17 cells

IL-17-producing antigen-specific human T cells elicit potent antitumor activity in mice. Yet, refinement of this approach is needed to position it for clinical use. While activation signal strength regulates IL-17 production by CD4+ T cells, the degree to which T cell antigen receptor (TCR) and cost...

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Veröffentlicht in:	Molecular therapy 2023-07, Vol.31 (7), p.2120-2131
Hauptverfasser:	Wyatt, Megan M., Huff, Logan W., Nelson, Michelle H., Neal, Lillian R., Medvec, Andrew R., Rangel Rivera, Guillermo O., Smith, Aubrey S., Rivera Reyes, Amalia M., Knochelmann, Hannah M., Riley, James L., Lesinski, Gregory B., Paulos, Chrystal M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CAR-T CD28 Antigens - genetics cellular therapy Humans ICOS inducible costimulator Inducible T-Cell Co-Stimulator Protein - metabolism Interleukin-17 - metabolism Lymphocyte Activation Mice Original Phosphoenolpyruvate - metabolism Receptors, Antigen, T-Cell - metabolism Receptors, Chimeric Antigen - genetics Receptors, Chimeric Antigen - metabolism Signal Transduction TCR signal strength Th17 Th17 Cells - metabolism
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