Targeting m6A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer

ObjectiveThe role of N6-methyladenosine (m6A) in tumour immune microenvironment (TIME) remains understudied. Here, we elucidate function and mechanism of YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) in colorectal cancer (CRC) TIME.DesignClinical significance of YTHDF1 was assessed in tissue...

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Veröffentlicht in:	Gut 2023-08, Vol.72 (8), p.1497-1509
Hauptverfasser:	Bao, Yi, Zhai, Jianning, Chen, Huarong, Wong, Chi Chun, Liang, Cong, Ding, Yanqiang, Huang, Dan, Gou, Hongyan, Chen, Danyu, Pan, Yasi, Kang, Wei, To, Ka Fai, Yu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Azoxymethane CD8 antigen Colon colon carcinogenesis Colorectal cancer Colorectal carcinoma CRISPR CXCR2 protein Cytotoxicity Data analysis Dextran DNA microarrays Genes Genomes GI cancer Immune checkpoint inhibitors Immunity Immunoprecipitation Immunotherapy Interferon Lymphocytes Lymphocytes T Medical prognosis Metastases Microenvironments N6-methyladenosine Nanoparticles PD-1 protein Protein expression Proteins RNA-binding protein siRNA Statistical analysis Stem cells Suppressor cells Therapeutic targets Tumors γ-Interferon
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