Differentially expressed genes PCCA, ECHS1, and HADH are potential prognostic biomarkers for gastric cancer
Gastric cancer (GC) is one of the most common malignant tumors in the world. As far as we know, no biomarker has been widely accepted for early diagnosis and prognosis prediction of GC. The purpose of this study is to find potential biomarkers to predict the prognosis of GC. The differentially expre...
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| Veröffentlicht in: | Science progress (1916) 2021-04, Vol.104 (2), p.1-14 |
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| description | Gastric cancer (GC) is one of the most common malignant tumors in the world. As far as we know, no biomarker has been widely accepted for early diagnosis and prognosis prediction of GC. The purpose of this study is to find potential biomarkers to predict the prognosis of GC. The differentially expressed gene (DEG) was analyzed from GSE93774. Enrichr was used to analyze the gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, the enrichment of transcription factors (TF), miRNA, and kinase. GO analysis showed DEGs was enriched in the process of amino acid metabolism. Pathway results showed DEGs was mainly enriched in cell cycle. Propionyl CoA carboxylase alpha (PCCA), Enoyl coenzyme A hydratase short chain 1 (ECHS1), and 3-hydroxyacyl-CoA dehydrogenase (HADH) have prognostic value in patients with GC. ECHS1 and HADH genes were significantly associated with disease-free survival. There was a significant correlation between PCCA and overall survival rate. The results of this study suggest that PCCA, ECHS1, and HADH may be new biomarkers for predicting the prognosis of GC. |
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As far as we know, no biomarker has been widely accepted for early diagnosis and prognosis prediction of GC. The purpose of this study is to find potential biomarkers to predict the prognosis of GC. The differentially expressed gene (DEG) was analyzed from GSE93774. Enrichr was used to analyze the gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, the enrichment of transcription factors (TF), miRNA, and kinase. GO analysis showed DEGs was enriched in the process of amino acid metabolism. Pathway results showed DEGs was mainly enriched in cell cycle. Propionyl CoA carboxylase alpha (PCCA), Enoyl coenzyme A hydratase short chain 1 (ECHS1), and 3-hydroxyacyl-CoA dehydrogenase (HADH) have prognostic value in patients with GC. ECHS1 and HADH genes were significantly associated with disease-free survival. There was a significant correlation between PCCA and overall survival rate. The results of this study suggest that PCCA, ECHS1, and HADH may be new biomarkers for predicting the prognosis of GC.</description><identifier>ISSN: 0036-8504</identifier><identifier>EISSN: 2047-7163</identifier><identifier>DOI: 10.1177/00368504211011344</identifier><identifier>PMID: 33881965</identifier><language>eng</language><publisher>London, England: Sage Publications, Ltd</publisher><subject>3-Hydroxyacyl-CoA dehydrogenase ; 3-Hydroxyacyl-CoA Dehydrogenase - genetics ; Amino acids ; Biomarkers ; Biomarkers, Tumor - genetics ; Cancer ; Cell cycle ; Coenzyme A ; Encyclopedias ; Enoyl-CoA Hydratase - genetics ; Enrichment ; Gastric cancer ; Gene Expression Profiling - methods ; Genes ; Genomes ; Humans ; Kinases ; Medical prognosis ; Methylmalonyl-CoA Decarboxylase ; miRNA ; Prognosis ; Stomach Neoplasms - diagnosis ; Stomach Neoplasms - genetics ; Stomach Neoplasms - metabolism ; Survival ; Transcription factors ; Tumors</subject><ispartof>Science progress (1916), 2021-04, Vol.104 (2), p.1-14</ispartof><rights>The Author(s) 2021</rights><rights>2021. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( https://creativecommons.org/licenses/by-nc/4.0/ ) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages ( https://us.sagepub.com/en-us/nam/open-access-at-sage ). 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As far as we know, no biomarker has been widely accepted for early diagnosis and prognosis prediction of GC. The purpose of this study is to find potential biomarkers to predict the prognosis of GC. The differentially expressed gene (DEG) was analyzed from GSE93774. Enrichr was used to analyze the gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, the enrichment of transcription factors (TF), miRNA, and kinase. GO analysis showed DEGs was enriched in the process of amino acid metabolism. Pathway results showed DEGs was mainly enriched in cell cycle. Propionyl CoA carboxylase alpha (PCCA), Enoyl coenzyme A hydratase short chain 1 (ECHS1), and 3-hydroxyacyl-CoA dehydrogenase (HADH) have prognostic value in patients with GC. ECHS1 and HADH genes were significantly associated with disease-free survival. There was a significant correlation between PCCA and overall survival rate. The results of this study suggest that PCCA, ECHS1, and HADH may be new biomarkers for predicting the prognosis of GC.</description><subject>3-Hydroxyacyl-CoA dehydrogenase</subject><subject>3-Hydroxyacyl-CoA Dehydrogenase - genetics</subject><subject>Amino acids</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Cancer</subject><subject>Cell cycle</subject><subject>Coenzyme A</subject><subject>Encyclopedias</subject><subject>Enoyl-CoA Hydratase - genetics</subject><subject>Enrichment</subject><subject>Gastric cancer</subject><subject>Gene Expression Profiling - methods</subject><subject>Genes</subject><subject>Genomes</subject><subject>Humans</subject><subject>Kinases</subject><subject>Medical prognosis</subject><subject>Methylmalonyl-CoA Decarboxylase</subject><subject>miRNA</subject><subject>Prognosis</subject><subject>Stomach Neoplasms - diagnosis</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Survival</subject><subject>Transcription factors</subject><subject>Tumors</subject><issn>0036-8504</issn><issn>2047-7163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><recordid>eNp9kV2L1DAUhoMo7jj6A7xQAt54sV1zmjRNr2Toro6woKBehyQ9rZ3tNDXpiPvvzdB1_ALJRSDv8745H4Q8BXYBUJavGONSFUzkAAyAC3GPrHImyqwEye-T1VHPjsAZeRTjjjEoQKqH5IxzpaCSxYrcXPZtiwHHuTfDcEvx-xQwRmxohyNG-qGuN-f0qt5-hHNqxoZuN5dbagLSyc-Li07Bd6OPc--o7f3ehBsMkbY-0M7EOaRnZ0aH4TF50Joh4pO7e00-v7n6VG-z6_dv39Wb68wJVc2ZLEyZjlJNI7GVaKyQVYWG2QqTUImyahVwidbIqig5AwvOWaFsbpRlyNfk9ZI7HeweG5fKDGbQU-hTbbfam17_qYz9F935bxoYL9K48pTw8i4h-K8HjLPe99HhMJgR_SHq_DhHkYs05jV58Re684cwpv4SVUCRS85FomChXPAxBmxP1QDTx13qf3aZPM9_b-Pk-Lm8BFwsQDQd_vr2f4nPFsMuzj6cAvOSCZ4s_AetdLAu</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Du, Zhongxiang</creator><creator>Zhang, Xiajun</creator><creator>Gao, Weiya</creator><creator>Yang, Jie</creator><general>Sage Publications, Ltd</general><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JQ2</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8524-2580</orcidid></search><sort><creationdate>20210401</creationdate><title>Differentially expressed genes PCCA, ECHS1, and HADH are potential prognostic biomarkers for gastric cancer</title><author>Du, Zhongxiang ; Zhang, Xiajun ; Gao, Weiya ; Yang, Jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-65a7a7a88dd6ef6eab4699ea0b9e7a79479f8136eba6957301b1ccb48b2a8b0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>3-Hydroxyacyl-CoA dehydrogenase</topic><topic>3-Hydroxyacyl-CoA Dehydrogenase - genetics</topic><topic>Amino acids</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Cancer</topic><topic>Cell cycle</topic><topic>Coenzyme A</topic><topic>Encyclopedias</topic><topic>Enoyl-CoA Hydratase - genetics</topic><topic>Enrichment</topic><topic>Gastric cancer</topic><topic>Gene Expression Profiling - methods</topic><topic>Genes</topic><topic>Genomes</topic><topic>Humans</topic><topic>Kinases</topic><topic>Medical prognosis</topic><topic>Methylmalonyl-CoA Decarboxylase</topic><topic>miRNA</topic><topic>Prognosis</topic><topic>Stomach Neoplasms - diagnosis</topic><topic>Stomach Neoplasms - genetics</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Survival</topic><topic>Transcription factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Du, Zhongxiang</creatorcontrib><creatorcontrib>Zhang, Xiajun</creatorcontrib><creatorcontrib>Gao, Weiya</creatorcontrib><creatorcontrib>Yang, Jie</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science progress (1916)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Du, Zhongxiang</au><au>Zhang, Xiajun</au><au>Gao, Weiya</au><au>Yang, Jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differentially expressed genes PCCA, ECHS1, and HADH are potential prognostic biomarkers for gastric cancer</atitle><jtitle>Science progress (1916)</jtitle><addtitle>Sci Prog</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>104</volume><issue>2</issue><spage>1</spage><epage>14</epage><pages>1-14</pages><issn>0036-8504</issn><eissn>2047-7163</eissn><abstract>Gastric cancer (GC) is one of the most common malignant tumors in the world. As far as we know, no biomarker has been widely accepted for early diagnosis and prognosis prediction of GC. The purpose of this study is to find potential biomarkers to predict the prognosis of GC. The differentially expressed gene (DEG) was analyzed from GSE93774. Enrichr was used to analyze the gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, the enrichment of transcription factors (TF), miRNA, and kinase. GO analysis showed DEGs was enriched in the process of amino acid metabolism. Pathway results showed DEGs was mainly enriched in cell cycle. Propionyl CoA carboxylase alpha (PCCA), Enoyl coenzyme A hydratase short chain 1 (ECHS1), and 3-hydroxyacyl-CoA dehydrogenase (HADH) have prognostic value in patients with GC. ECHS1 and HADH genes were significantly associated with disease-free survival. There was a significant correlation between PCCA and overall survival rate. The results of this study suggest that PCCA, ECHS1, and HADH may be new biomarkers for predicting the prognosis of GC.</abstract><cop>London, England</cop><pub>Sage Publications, Ltd</pub><pmid>33881965</pmid><doi>10.1177/00368504211011344</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-8524-2580</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 3-Hydroxyacyl-CoA dehydrogenase 3-Hydroxyacyl-CoA Dehydrogenase - genetics Amino acids Biomarkers Biomarkers, Tumor - genetics Cancer Cell cycle Coenzyme A Encyclopedias Enoyl-CoA Hydratase - genetics Enrichment Gastric cancer Gene Expression Profiling - methods Genes Genomes Humans Kinases Medical prognosis Methylmalonyl-CoA Decarboxylase miRNA Prognosis Stomach Neoplasms - diagnosis Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Survival Transcription factors Tumors |
| title | Differentially expressed genes PCCA, ECHS1, and HADH are potential prognostic biomarkers for gastric cancer |
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