Prospective Cohort Study of Ginseng Consumption in Association with Cancer Risk: Shanghai Women’s Health Study
Ginseng has been commonly used in Asian countries to promote longevity and health for >2000 years. Recent in vitro and in vivo studies, coupled with limited epidemiologic studies, have suggested that regular ginseng consumption may be related to lower cancer risk. We evaluated the association of...
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| Veröffentlicht in: | The Journal of nutrition 2023-04, Vol.153 (4), p.1170-1177 |
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| creator | Pradhan, Pranoti Wen, Wanqing Cai, Hui Gao, Yu-Tang Shu, Xiao-ou Zheng, Wei |
| description | Ginseng has been commonly used in Asian countries to promote longevity and health for >2000 years. Recent in vitro and in vivo studies, coupled with limited epidemiologic studies, have suggested that regular ginseng consumption may be related to lower cancer risk.
We evaluated the association of ginseng consumption with risk of total and 15 site-specific cancers in a large cohort study conducted among Chinese women. Given the previous literature on ginseng consumption and cancer risk, we hypothesized that ginseng consumption might be associated with varying risks of cancer.
This study included 65,732 female participants (mean age: 52.2 years) of the Shanghai Women’s Health Study, an ongoing prospective cohort study. Baseline enrollment occurred between 1997 and 2000, and follow-up concluded on 31 December 2016. Ginseng use and covariates were assessed via an in-person interview conducted at the baseline recruitment. The cohort was followed for cancer incidence. Cox proportional hazard models were used to estimate HRs and 95% CIs for ginseng-cancer associations after adjusting for confounders.
During a mean 14.7 years of follow-up, 5067 incident cancer cases were identified. Overall, regular ginseng use was mostly not associated with risk of any site-specific cancer, or all cancers combined. Short-term ( |
| doi_str_mv | 10.1016/j.tjnut.2023.02.032 |
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We evaluated the association of ginseng consumption with risk of total and 15 site-specific cancers in a large cohort study conducted among Chinese women. Given the previous literature on ginseng consumption and cancer risk, we hypothesized that ginseng consumption might be associated with varying risks of cancer.
This study included 65,732 female participants (mean age: 52.2 years) of the Shanghai Women’s Health Study, an ongoing prospective cohort study. Baseline enrollment occurred between 1997 and 2000, and follow-up concluded on 31 December 2016. Ginseng use and covariates were assessed via an in-person interview conducted at the baseline recruitment. The cohort was followed for cancer incidence. Cox proportional hazard models were used to estimate HRs and 95% CIs for ginseng-cancer associations after adjusting for confounders.
During a mean 14.7 years of follow-up, 5067 incident cancer cases were identified. Overall, regular ginseng use was mostly not associated with risk of any site-specific cancer, or all cancers combined. Short-term (<3 years) ginseng use was found to be significantly associated with increased risk of liver cancer (HR = 1.71; 95% CI: 1.04, 2.79; P = 0.035), whereas long-term (≥3 years) ginseng use was found to be associated with increased risk of thyroid cancer (HR = 1.40; 95% CI: 1.02, 1.91; P = 0.036). Long-term ginseng use was found to be significantly associated with decreased risk of lymphatic and hematopoietic tissue malignancy (HR = 0.67; 95% CI: 0.46, 0.98; P = 0.039) and non-Hodgkin’s lymphoma (HR = 0.57; 95% CI: 0.34, 0.97; P = 0.039).
This study provides suggestive evidence that ginseng consumption may be associated with risk of certain cancers.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1016/j.tjnut.2023.02.032</identifier><identifier>PMID: 36863482</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Asian ; Cancer ; China - epidemiology ; Cohort analysis ; Cohort Studies ; complementary medicine ; Consumption ; Diet ; Epidemiology ; Female ; Flowers & plants ; Ginseng ; Health ; Health risks ; Herbal medicine ; Humans ; In vivo methods and tests ; incidence ; Liver cancer ; Liver Neoplasms ; Lymphoma ; Malignancy ; Middle Aged ; Non-Hodgkin's lymphoma ; Nutrition ; Nutritional Epidemiology ; Panax ; Prospective Studies ; Risk ; Risk Factors ; Risk reduction ; Statistical models ; Thyroid ; Thyroid cancer ; Women's Health</subject><ispartof>The Journal of nutrition, 2023-04, Vol.153 (4), p.1170-1177</ispartof><rights>2023 American Society for Nutrition</rights><rights>Copyright © 2023 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright American Institute of Nutrition Apr 2023</rights><rights>2023 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. 2023 American Society for Nutrition</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-37a374bc1163b5d6ef0b01e80e2d605b166071db6e2781a7d1b2fe462922f1613</citedby><cites>FETCH-LOGICAL-c443t-37a374bc1163b5d6ef0b01e80e2d605b166071db6e2781a7d1b2fe462922f1613</cites><orcidid>0000-0003-1226-070X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36863482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pradhan, Pranoti</creatorcontrib><creatorcontrib>Wen, Wanqing</creatorcontrib><creatorcontrib>Cai, Hui</creatorcontrib><creatorcontrib>Gao, Yu-Tang</creatorcontrib><creatorcontrib>Shu, Xiao-ou</creatorcontrib><creatorcontrib>Zheng, Wei</creatorcontrib><title>Prospective Cohort Study of Ginseng Consumption in Association with Cancer Risk: Shanghai Women’s Health Study</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Ginseng has been commonly used in Asian countries to promote longevity and health for >2000 years. Recent in vitro and in vivo studies, coupled with limited epidemiologic studies, have suggested that regular ginseng consumption may be related to lower cancer risk.
We evaluated the association of ginseng consumption with risk of total and 15 site-specific cancers in a large cohort study conducted among Chinese women. Given the previous literature on ginseng consumption and cancer risk, we hypothesized that ginseng consumption might be associated with varying risks of cancer.
This study included 65,732 female participants (mean age: 52.2 years) of the Shanghai Women’s Health Study, an ongoing prospective cohort study. Baseline enrollment occurred between 1997 and 2000, and follow-up concluded on 31 December 2016. Ginseng use and covariates were assessed via an in-person interview conducted at the baseline recruitment. The cohort was followed for cancer incidence. Cox proportional hazard models were used to estimate HRs and 95% CIs for ginseng-cancer associations after adjusting for confounders.
During a mean 14.7 years of follow-up, 5067 incident cancer cases were identified. Overall, regular ginseng use was mostly not associated with risk of any site-specific cancer, or all cancers combined. Short-term (<3 years) ginseng use was found to be significantly associated with increased risk of liver cancer (HR = 1.71; 95% CI: 1.04, 2.79; P = 0.035), whereas long-term (≥3 years) ginseng use was found to be associated with increased risk of thyroid cancer (HR = 1.40; 95% CI: 1.02, 1.91; P = 0.036). Long-term ginseng use was found to be significantly associated with decreased risk of lymphatic and hematopoietic tissue malignancy (HR = 0.67; 95% CI: 0.46, 0.98; P = 0.039) and non-Hodgkin’s lymphoma (HR = 0.57; 95% CI: 0.34, 0.97; P = 0.039).
This study provides suggestive evidence that ginseng consumption may be associated with risk of certain cancers.</description><subject>Asian</subject><subject>Cancer</subject><subject>China - epidemiology</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>complementary medicine</subject><subject>Consumption</subject><subject>Diet</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Flowers & plants</subject><subject>Ginseng</subject><subject>Health</subject><subject>Health risks</subject><subject>Herbal medicine</subject><subject>Humans</subject><subject>In vivo methods and tests</subject><subject>incidence</subject><subject>Liver cancer</subject><subject>Liver Neoplasms</subject><subject>Lymphoma</subject><subject>Malignancy</subject><subject>Middle Aged</subject><subject>Non-Hodgkin's lymphoma</subject><subject>Nutrition</subject><subject>Nutritional Epidemiology</subject><subject>Panax</subject><subject>Prospective Studies</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Risk reduction</subject><subject>Statistical models</subject><subject>Thyroid</subject><subject>Thyroid cancer</subject><subject>Women's Health</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhi0EokvhCZCQJS5cEsZ24iRICFUr2iJVAlEQR8tJJhuHxF7sZFFvfQ1ejyfB3S0VcOBk2f78j2c-Qp4ySBkw-XJI58Euc8qBixR4CoLfIyuWZyyRDOA-WQFwnggm5RF5FMIAACyryofkSMhSiqzkK7L94F3YYjObHdK1652f6eW8tFfUdfTM2IB2E89tWKbtbJylxtKTEFxj9H773cw9XWvboKcfTfj6il722m56begXN6H9ef0j0HPUY8T2uY_Jg06PAZ_crsfk8-nbT-vz5OL92bv1yUXSZJmYE1FoUWR1w5gUdd5K7KAGhiUgbyXkdWwKCtbWEnlRMl20rOYdZpJXnHdMMnFM3hxyt0s9Ydugnb0e1dabSfsr5bRRf99Y06uN2ykGIpdVlcWEF7cJ3n1bMMxqMqHBcdQW3RJULCyySrCsjOjzf9DBLd7G_hQvgVdFwYo8UuJANXHmwWN39xsG6kapGtReqbpRqoCrqDS-evZnI3dvfjuMwOsDgHGcO4NehcZgNNIaH8Wq1pn_FvgFmAW1RA</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Pradhan, Pranoti</creator><creator>Wen, Wanqing</creator><creator>Cai, Hui</creator><creator>Gao, Yu-Tang</creator><creator>Shu, Xiao-ou</creator><creator>Zheng, Wei</creator><general>Elsevier Inc</general><general>American Institute of Nutrition</general><general>American Society for Nutrition</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1226-070X</orcidid></search><sort><creationdate>20230401</creationdate><title>Prospective Cohort Study of Ginseng Consumption in Association with Cancer Risk: Shanghai Women’s Health Study</title><author>Pradhan, Pranoti ; Wen, Wanqing ; Cai, Hui ; Gao, Yu-Tang ; Shu, Xiao-ou ; Zheng, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-37a374bc1163b5d6ef0b01e80e2d605b166071db6e2781a7d1b2fe462922f1613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Asian</topic><topic>Cancer</topic><topic>China - epidemiology</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>complementary medicine</topic><topic>Consumption</topic><topic>Diet</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Flowers & plants</topic><topic>Ginseng</topic><topic>Health</topic><topic>Health risks</topic><topic>Herbal medicine</topic><topic>Humans</topic><topic>In vivo methods and tests</topic><topic>incidence</topic><topic>Liver cancer</topic><topic>Liver Neoplasms</topic><topic>Lymphoma</topic><topic>Malignancy</topic><topic>Middle Aged</topic><topic>Non-Hodgkin's lymphoma</topic><topic>Nutrition</topic><topic>Nutritional Epidemiology</topic><topic>Panax</topic><topic>Prospective Studies</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Risk reduction</topic><topic>Statistical models</topic><topic>Thyroid</topic><topic>Thyroid cancer</topic><topic>Women's Health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pradhan, Pranoti</creatorcontrib><creatorcontrib>Wen, Wanqing</creatorcontrib><creatorcontrib>Cai, Hui</creatorcontrib><creatorcontrib>Gao, Yu-Tang</creatorcontrib><creatorcontrib>Shu, Xiao-ou</creatorcontrib><creatorcontrib>Zheng, Wei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pradhan, Pranoti</au><au>Wen, Wanqing</au><au>Cai, Hui</au><au>Gao, Yu-Tang</au><au>Shu, Xiao-ou</au><au>Zheng, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospective Cohort Study of Ginseng Consumption in Association with Cancer Risk: Shanghai Women’s Health Study</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>153</volume><issue>4</issue><spage>1170</spage><epage>1177</epage><pages>1170-1177</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><abstract>Ginseng has been commonly used in Asian countries to promote longevity and health for >2000 years. Recent in vitro and in vivo studies, coupled with limited epidemiologic studies, have suggested that regular ginseng consumption may be related to lower cancer risk.
We evaluated the association of ginseng consumption with risk of total and 15 site-specific cancers in a large cohort study conducted among Chinese women. Given the previous literature on ginseng consumption and cancer risk, we hypothesized that ginseng consumption might be associated with varying risks of cancer.
This study included 65,732 female participants (mean age: 52.2 years) of the Shanghai Women’s Health Study, an ongoing prospective cohort study. Baseline enrollment occurred between 1997 and 2000, and follow-up concluded on 31 December 2016. Ginseng use and covariates were assessed via an in-person interview conducted at the baseline recruitment. The cohort was followed for cancer incidence. Cox proportional hazard models were used to estimate HRs and 95% CIs for ginseng-cancer associations after adjusting for confounders.
During a mean 14.7 years of follow-up, 5067 incident cancer cases were identified. Overall, regular ginseng use was mostly not associated with risk of any site-specific cancer, or all cancers combined. Short-term (<3 years) ginseng use was found to be significantly associated with increased risk of liver cancer (HR = 1.71; 95% CI: 1.04, 2.79; P = 0.035), whereas long-term (≥3 years) ginseng use was found to be associated with increased risk of thyroid cancer (HR = 1.40; 95% CI: 1.02, 1.91; P = 0.036). Long-term ginseng use was found to be significantly associated with decreased risk of lymphatic and hematopoietic tissue malignancy (HR = 0.67; 95% CI: 0.46, 0.98; P = 0.039) and non-Hodgkin’s lymphoma (HR = 0.57; 95% CI: 0.34, 0.97; P = 0.039).
This study provides suggestive evidence that ginseng consumption may be associated with risk of certain cancers.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>36863482</pmid><doi>10.1016/j.tjnut.2023.02.032</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1226-070X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Asian Cancer China - epidemiology Cohort analysis Cohort Studies complementary medicine Consumption Diet Epidemiology Female Flowers & plants Ginseng Health Health risks Herbal medicine Humans In vivo methods and tests incidence Liver cancer Liver Neoplasms Lymphoma Malignancy Middle Aged Non-Hodgkin's lymphoma Nutrition Nutritional Epidemiology Panax Prospective Studies Risk Risk Factors Risk reduction Statistical models Thyroid Thyroid cancer Women's Health |
| title | Prospective Cohort Study of Ginseng Consumption in Association with Cancer Risk: Shanghai Women’s Health Study |
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