Right to left ventricular volume ratio is associated with mortality in congenital diaphragmatic hernia
Background Congenital diaphragmatic hernia (CDH) is associated with high neonatal mortality. We performed this study to test the hypothesis that left ventricular (LV) and right ventricular (RV) volumes assessed by three-dimensional echocardiography may be associated with mortality in CDH. Methods Th...
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| Veröffentlicht in: | Pediatric research 2023-07, Vol.94 (1), p.304-312 |
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| creator | Toyoshima, Katsuaki Saito, Tomoko Shimokaze, Tomoyuki Katsumata, Kaoru Ohmura, Junya Kimura, Sasagu Aoki, Hirosato Takahashi, Megumi Shibasaki, Jun Kawataki, Motoyoshi Kim, Ki-Sung Shinkai, Masato Ishikawa, Hiroshi Saito, Naka Masutani, Satoshi |
| description | Background
Congenital diaphragmatic hernia (CDH) is associated with high neonatal mortality. We performed this study to test the hypothesis that left ventricular (LV) and right ventricular (RV) volumes assessed by three-dimensional echocardiography may be associated with mortality in CDH.
Methods
This study was a single-center retrospective cohort study involving 35 infants with CDH. RV and LV end-diastolic volume (RVEDV and LVEDV, respectively) were measured by three-dimensional echocardiography and were corrected by birth body weight (BBW) on day 1. RVEDV/BBW, LVEDV/BBW, and LVEDV/RVEDV were compared between CDH survivors and non-survivors. Receiver-operating characteristic curve analysis was performed to assess the predictive ability for mortality of the echocardiographic parameters.
Results
Comparing CDH non-survivors (
n
= 6) with survivors (
n
= 29), respectively, RVEDV/BBW was significantly larger (2.54 ± 0.33 vs 1.86 ± 0.35 ml/kg;
P
|
| doi_str_mv | 10.1038/s41390-022-02430-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10356601</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2763333707</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-bec09003c27c6e03bfba127c7c52b004b019ff9b08103f9ceec44bdfe133533</originalsourceid><addsrcrecordid>eNp9UdtqFTEUDaLYY_UH-iABX3yZunOZS56KFK2FgqC-h0xOciZlZnJMMkfar-9uT-3FBwMhm-y11r4sQo4YHDMQ3acsmVBQAed4pYDq-gVZsRoDkLJ9SVYAglVCqe6AvMn5EoDJupOvyYFoGi55J1fE_wibodAS6eh8oTs3lxTsMppEd3FcJkeTKSHSkKnJOdpgilvTP6EMdIqpmDGUKxpmauO8cXPAD7oOZjsks5mQaOng0hzMW_LKmzG7d_fvIfn59cuv02_Vxfez89PPF5WVbV2q3llQ2LXlrW0ciN73hmHc2pr3ALIHprxXPXS4AK-sc1bKfu0dE6IW4pCc7FW3Sz-5tb0dxox6m8Jk0pWOJujnmTkMehN3GtXqpgGGCh_vFVL8vbhc9BSydeNoZheXrHnbCDwttAj98A_0Mi5pxuk074SqVSuEQhTfo2yKOSfnH7phcFu203sXNbqo71zU10h6_3SOB8pf2xAg9oCMKVx8eqz9H9kbwOmrTA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2839597339</pqid></control><display><type>article</type><title>Right to left ventricular volume ratio is associated with mortality in congenital diaphragmatic hernia</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Toyoshima, Katsuaki ; Saito, Tomoko ; Shimokaze, Tomoyuki ; Katsumata, Kaoru ; Ohmura, Junya ; Kimura, Sasagu ; Aoki, Hirosato ; Takahashi, Megumi ; Shibasaki, Jun ; Kawataki, Motoyoshi ; Kim, Ki-Sung ; Shinkai, Masato ; Ishikawa, Hiroshi ; Saito, Naka ; Masutani, Satoshi</creator><creatorcontrib>Toyoshima, Katsuaki ; Saito, Tomoko ; Shimokaze, Tomoyuki ; Katsumata, Kaoru ; Ohmura, Junya ; Kimura, Sasagu ; Aoki, Hirosato ; Takahashi, Megumi ; Shibasaki, Jun ; Kawataki, Motoyoshi ; Kim, Ki-Sung ; Shinkai, Masato ; Ishikawa, Hiroshi ; Saito, Naka ; Masutani, Satoshi</creatorcontrib><description>Background
Congenital diaphragmatic hernia (CDH) is associated with high neonatal mortality. We performed this study to test the hypothesis that left ventricular (LV) and right ventricular (RV) volumes assessed by three-dimensional echocardiography may be associated with mortality in CDH.
Methods
This study was a single-center retrospective cohort study involving 35 infants with CDH. RV and LV end-diastolic volume (RVEDV and LVEDV, respectively) were measured by three-dimensional echocardiography and were corrected by birth body weight (BBW) on day 1. RVEDV/BBW, LVEDV/BBW, and LVEDV/RVEDV were compared between CDH survivors and non-survivors. Receiver-operating characteristic curve analysis was performed to assess the predictive ability for mortality of the echocardiographic parameters.
Results
Comparing CDH non-survivors (
n
= 6) with survivors (
n
= 29), respectively, RVEDV/BBW was significantly larger (2.54 ± 0.33 vs 1.86 ± 0.35 ml/kg;
P
< 0.01), LVEDV/BBW was significantly smaller (0.86 ± 0.21 vs 1.22 ± 0.33 ml/kg;
P
< 0.001), and LVEDV/RVEDV was significantly lower (0.34 ± 0.06 vs 0.66 ± 0.18;
P
< 0.001). The area under the curve for LVEDV/RVEDV was the largest (0.98).
Conclusions
Three-dimensional echocardiographic volume imbalance between the RV and LV was remarkable in CDH non-survivors. The LVEDV/RVEDV ratio may be associated with mortality in CDH.
Impact
Mortality with congenital diaphragmatic hernia (CDH) is high, and evaluating left and right ventricular structures and functions may be helpful in assessing the prognosis.
Three-dimensional (3D) echocardiography indicated that the left ventricular end-diastolic volume/right ventricular end-diastolic volume ratio within 24 h after birth was associated with mortality in CDH infants.
The usefulness of this ratio should be validated in prospective multicenter studies involving larger numbers of patients.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/s41390-022-02430-z</identifier><identifier>PMID: 36624284</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Clinical ; Clinical Research Article ; Echocardiography - methods ; Heart Ventricles - diagnostic imaging ; Hernias ; Hernias, Diaphragmatic, Congenital - complications ; Humans ; Infant ; Infant, Newborn ; Medicine ; Medicine & Public Health ; Mortality ; Pediatric Surgery ; Pediatrics ; Prospective Studies ; Retrospective Studies</subject><ispartof>Pediatric research, 2023-07, Vol.94 (1), p.304-312</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-bec09003c27c6e03bfba127c7c52b004b019ff9b08103f9ceec44bdfe133533</citedby><cites>FETCH-LOGICAL-c475t-bec09003c27c6e03bfba127c7c52b004b019ff9b08103f9ceec44bdfe133533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36624284$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Toyoshima, Katsuaki</creatorcontrib><creatorcontrib>Saito, Tomoko</creatorcontrib><creatorcontrib>Shimokaze, Tomoyuki</creatorcontrib><creatorcontrib>Katsumata, Kaoru</creatorcontrib><creatorcontrib>Ohmura, Junya</creatorcontrib><creatorcontrib>Kimura, Sasagu</creatorcontrib><creatorcontrib>Aoki, Hirosato</creatorcontrib><creatorcontrib>Takahashi, Megumi</creatorcontrib><creatorcontrib>Shibasaki, Jun</creatorcontrib><creatorcontrib>Kawataki, Motoyoshi</creatorcontrib><creatorcontrib>Kim, Ki-Sung</creatorcontrib><creatorcontrib>Shinkai, Masato</creatorcontrib><creatorcontrib>Ishikawa, Hiroshi</creatorcontrib><creatorcontrib>Saito, Naka</creatorcontrib><creatorcontrib>Masutani, Satoshi</creatorcontrib><title>Right to left ventricular volume ratio is associated with mortality in congenital diaphragmatic hernia</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background
Congenital diaphragmatic hernia (CDH) is associated with high neonatal mortality. We performed this study to test the hypothesis that left ventricular (LV) and right ventricular (RV) volumes assessed by three-dimensional echocardiography may be associated with mortality in CDH.
Methods
This study was a single-center retrospective cohort study involving 35 infants with CDH. RV and LV end-diastolic volume (RVEDV and LVEDV, respectively) were measured by three-dimensional echocardiography and were corrected by birth body weight (BBW) on day 1. RVEDV/BBW, LVEDV/BBW, and LVEDV/RVEDV were compared between CDH survivors and non-survivors. Receiver-operating characteristic curve analysis was performed to assess the predictive ability for mortality of the echocardiographic parameters.
Results
Comparing CDH non-survivors (
n
= 6) with survivors (
n
= 29), respectively, RVEDV/BBW was significantly larger (2.54 ± 0.33 vs 1.86 ± 0.35 ml/kg;
P
< 0.01), LVEDV/BBW was significantly smaller (0.86 ± 0.21 vs 1.22 ± 0.33 ml/kg;
P
< 0.001), and LVEDV/RVEDV was significantly lower (0.34 ± 0.06 vs 0.66 ± 0.18;
P
< 0.001). The area under the curve for LVEDV/RVEDV was the largest (0.98).
Conclusions
Three-dimensional echocardiographic volume imbalance between the RV and LV was remarkable in CDH non-survivors. The LVEDV/RVEDV ratio may be associated with mortality in CDH.
Impact
Mortality with congenital diaphragmatic hernia (CDH) is high, and evaluating left and right ventricular structures and functions may be helpful in assessing the prognosis.
Three-dimensional (3D) echocardiography indicated that the left ventricular end-diastolic volume/right ventricular end-diastolic volume ratio within 24 h after birth was associated with mortality in CDH infants.
The usefulness of this ratio should be validated in prospective multicenter studies involving larger numbers of patients.</description><subject>Clinical</subject><subject>Clinical Research Article</subject><subject>Echocardiography - methods</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>Hernias</subject><subject>Hernias, Diaphragmatic, Congenital - complications</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Prospective Studies</subject><subject>Retrospective Studies</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9UdtqFTEUDaLYY_UH-iABX3yZunOZS56KFK2FgqC-h0xOciZlZnJMMkfar-9uT-3FBwMhm-y11r4sQo4YHDMQ3acsmVBQAed4pYDq-gVZsRoDkLJ9SVYAglVCqe6AvMn5EoDJupOvyYFoGi55J1fE_wibodAS6eh8oTs3lxTsMppEd3FcJkeTKSHSkKnJOdpgilvTP6EMdIqpmDGUKxpmauO8cXPAD7oOZjsks5mQaOng0hzMW_LKmzG7d_fvIfn59cuv02_Vxfez89PPF5WVbV2q3llQ2LXlrW0ciN73hmHc2pr3ALIHprxXPXS4AK-sc1bKfu0dE6IW4pCc7FW3Sz-5tb0dxox6m8Jk0pWOJujnmTkMehN3GtXqpgGGCh_vFVL8vbhc9BSydeNoZheXrHnbCDwttAj98A_0Mi5pxuk074SqVSuEQhTfo2yKOSfnH7phcFu203sXNbqo71zU10h6_3SOB8pf2xAg9oCMKVx8eqz9H9kbwOmrTA</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Toyoshima, Katsuaki</creator><creator>Saito, Tomoko</creator><creator>Shimokaze, Tomoyuki</creator><creator>Katsumata, Kaoru</creator><creator>Ohmura, Junya</creator><creator>Kimura, Sasagu</creator><creator>Aoki, Hirosato</creator><creator>Takahashi, Megumi</creator><creator>Shibasaki, Jun</creator><creator>Kawataki, Motoyoshi</creator><creator>Kim, Ki-Sung</creator><creator>Shinkai, Masato</creator><creator>Ishikawa, Hiroshi</creator><creator>Saito, Naka</creator><creator>Masutani, Satoshi</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230701</creationdate><title>Right to left ventricular volume ratio is associated with mortality in congenital diaphragmatic hernia</title><author>Toyoshima, Katsuaki ; Saito, Tomoko ; Shimokaze, Tomoyuki ; Katsumata, Kaoru ; Ohmura, Junya ; Kimura, Sasagu ; Aoki, Hirosato ; Takahashi, Megumi ; Shibasaki, Jun ; Kawataki, Motoyoshi ; Kim, Ki-Sung ; Shinkai, Masato ; Ishikawa, Hiroshi ; Saito, Naka ; Masutani, Satoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-bec09003c27c6e03bfba127c7c52b004b019ff9b08103f9ceec44bdfe133533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Clinical</topic><topic>Clinical Research Article</topic><topic>Echocardiography - methods</topic><topic>Heart Ventricles - diagnostic imaging</topic><topic>Hernias</topic><topic>Hernias, Diaphragmatic, Congenital - complications</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mortality</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Prospective Studies</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Toyoshima, Katsuaki</creatorcontrib><creatorcontrib>Saito, Tomoko</creatorcontrib><creatorcontrib>Shimokaze, Tomoyuki</creatorcontrib><creatorcontrib>Katsumata, Kaoru</creatorcontrib><creatorcontrib>Ohmura, Junya</creatorcontrib><creatorcontrib>Kimura, Sasagu</creatorcontrib><creatorcontrib>Aoki, Hirosato</creatorcontrib><creatorcontrib>Takahashi, Megumi</creatorcontrib><creatorcontrib>Shibasaki, Jun</creatorcontrib><creatorcontrib>Kawataki, Motoyoshi</creatorcontrib><creatorcontrib>Kim, Ki-Sung</creatorcontrib><creatorcontrib>Shinkai, Masato</creatorcontrib><creatorcontrib>Ishikawa, Hiroshi</creatorcontrib><creatorcontrib>Saito, Naka</creatorcontrib><creatorcontrib>Masutani, Satoshi</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Toyoshima, Katsuaki</au><au>Saito, Tomoko</au><au>Shimokaze, Tomoyuki</au><au>Katsumata, Kaoru</au><au>Ohmura, Junya</au><au>Kimura, Sasagu</au><au>Aoki, Hirosato</au><au>Takahashi, Megumi</au><au>Shibasaki, Jun</au><au>Kawataki, Motoyoshi</au><au>Kim, Ki-Sung</au><au>Shinkai, Masato</au><au>Ishikawa, Hiroshi</au><au>Saito, Naka</au><au>Masutani, Satoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Right to left ventricular volume ratio is associated with mortality in congenital diaphragmatic hernia</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>94</volume><issue>1</issue><spage>304</spage><epage>312</epage><pages>304-312</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background
Congenital diaphragmatic hernia (CDH) is associated with high neonatal mortality. We performed this study to test the hypothesis that left ventricular (LV) and right ventricular (RV) volumes assessed by three-dimensional echocardiography may be associated with mortality in CDH.
Methods
This study was a single-center retrospective cohort study involving 35 infants with CDH. RV and LV end-diastolic volume (RVEDV and LVEDV, respectively) were measured by three-dimensional echocardiography and were corrected by birth body weight (BBW) on day 1. RVEDV/BBW, LVEDV/BBW, and LVEDV/RVEDV were compared between CDH survivors and non-survivors. Receiver-operating characteristic curve analysis was performed to assess the predictive ability for mortality of the echocardiographic parameters.
Results
Comparing CDH non-survivors (
n
= 6) with survivors (
n
= 29), respectively, RVEDV/BBW was significantly larger (2.54 ± 0.33 vs 1.86 ± 0.35 ml/kg;
P
< 0.01), LVEDV/BBW was significantly smaller (0.86 ± 0.21 vs 1.22 ± 0.33 ml/kg;
P
< 0.001), and LVEDV/RVEDV was significantly lower (0.34 ± 0.06 vs 0.66 ± 0.18;
P
< 0.001). The area under the curve for LVEDV/RVEDV was the largest (0.98).
Conclusions
Three-dimensional echocardiographic volume imbalance between the RV and LV was remarkable in CDH non-survivors. The LVEDV/RVEDV ratio may be associated with mortality in CDH.
Impact
Mortality with congenital diaphragmatic hernia (CDH) is high, and evaluating left and right ventricular structures and functions may be helpful in assessing the prognosis.
Three-dimensional (3D) echocardiography indicated that the left ventricular end-diastolic volume/right ventricular end-diastolic volume ratio within 24 h after birth was associated with mortality in CDH infants.
The usefulness of this ratio should be validated in prospective multicenter studies involving larger numbers of patients.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>36624284</pmid><doi>10.1038/s41390-022-02430-z</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Pediatric research, 2023-07, Vol.94 (1), p.304-312 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10356601 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Clinical Clinical Research Article Echocardiography - methods Heart Ventricles - diagnostic imaging Hernias Hernias, Diaphragmatic, Congenital - complications Humans Infant Infant, Newborn Medicine Medicine & Public Health Mortality Pediatric Surgery Pediatrics Prospective Studies Retrospective Studies |
| title | Right to left ventricular volume ratio is associated with mortality in congenital diaphragmatic hernia |
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