Characterization of Two Novel Inhibitors of the Mycobacterium tuberculosis Cytochrome bc1 Complex

Drug-resistant tuberculosis is a global health care threat calling for novel effective treatment options. Here, we report on two novel cytochrome bc1 inhibitors (MJ-22 and B6) targeting the Mycobacterium tuberculosis respiratory chain with excellent intracellular activities in human macrophages. Bot...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2023-07, Vol.67 (7), p.e0025123-e0025123
Hauptverfasser:	Gries, Raphael, Dal Molin, Michael, Chhen, Jason, van Gumpel, Edeltraud, Dreyer, Viola, Niemann, Stefan, Rybniker, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Mechanisms of Action: Physiological Effects
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creator	Gries, Raphael Dal Molin, Michael Chhen, Jason van Gumpel, Edeltraud Dreyer, Viola Niemann, Stefan Rybniker, Jan
description	Drug-resistant tuberculosis is a global health care threat calling for novel effective treatment options. Here, we report on two novel cytochrome bc1 inhibitors (MJ-22 and B6) targeting the Mycobacterium tuberculosis respiratory chain with excellent intracellular activities in human macrophages. Both hit compounds revealed very low mutation frequencies and distinct cross-resistance patterns with other advanced cytochrome bc1 inhibitors.
doi_str_mv	10.1128/aac.00251-23
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subjects	Mechanisms of Action: Physiological Effects
title	Characterization of Two Novel Inhibitors of the Mycobacterium tuberculosis Cytochrome bc1 Complex
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