Characterization of Xenobiotic and Steroid Disposition Potential of Human Placental Tissue and Cell Lines (BeWo, JEG-3, JAR, and HTR-8/SVneo) by Quantitative Proteomics

The placenta is a fetal organ that performs critical functions to maintain pregnancy and support fetal development, including metabolism and transport of xenobiotics and steroids between the maternal-fetal unit. In vitro placenta models are used to study xenobiotic and steroid disposition, but how w...

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Veröffentlicht in:	Drug metabolism and disposition 2023-08, Vol.51 (8), p.1053-1063
Hauptverfasser:	Kruger, Laken, Lapehn, Samantha, Paquette, Alison, Singh, Dilip Kumar, MacDonald, James, Bammler, Theo K, Enquobahrie, Daniel A, Zhao, Qi, Mozhui, Khyobeni, Sathyanarayana, Sheela, Prasad, Bhagwat
Format:	Artikel
Sprache:	eng
Schlagworte:	Aromatase - metabolism ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism Cell Line, Tumor Female Humans Neoplasm Proteins - metabolism Placenta - metabolism Pregnancy Proteomics Steroids - metabolism Xenobiotics - metabolism
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