Left bundle branch area pacing in mildly reduced heart failure: A systematic literature review and meta‐analysis
Cardiac resynchronization therapy (CRT) strategy for heart failure with mildly reduced ejection fraction (HFmrEF) is controversial. Left bundle branch area pacing (LBBAP) is an emerging pacing modality and an alternative option to CRT. This analysis aimed to perform a systematic review of the litera...
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| Veröffentlicht in: | Clinical cardiology (Mahwah, N.J.) N.J.), 2023-07, Vol.46 (7), p.713-720 |
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| description | Cardiac resynchronization therapy (CRT) strategy for heart failure with mildly reduced ejection fraction (HFmrEF) is controversial. Left bundle branch area pacing (LBBAP) is an emerging pacing modality and an alternative option to CRT. This analysis aimed to perform a systematic review of the literature and meta‐analysis on the impact of the LBBAP strategy in HFmrEF, with left ventricular ejection fraction (LVEF) between 35% and 50%. PubMed, Embase, and Cochrane Library were searched for full‐text articles on LBBAP from inception to July 17, 2022. The outcomes of interest were QRS duration and LVEF at baseline and follow‐up in mid‐range heart failure. Data were extracted and summarized. A random‐effect model incorporating the potential heterogeneity was used to synthesize the results. Out of 1065 articles, 8 met the inclusion criteria for 211 mid‐range heart failure patients with an implant LBBAP across the 16 centers. The average implant success rate with lumenless pacing lead use was 91.3%, and 19 complications were reported among all 211 enrolled patients. During the average follow‐up of 9.1 months, the average LVEF was 39.8% at baseline and 50.5% at follow‐up (MD: 10.90%, 95% CI: 6.56−15.23, p |
| doi_str_mv | 10.1002/clc.24028 |
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Average left ventricular ejection fraction (LVEF) from implant to follow‐up for baseline LVEF between 35% and 50% versus LVEF <35%.
▪ Left bundle branch area pacing (LBBAP) was found to significantly shorten QRS duration and improve systolic cardiac function in patients with a LVEF of 35%−50%.
▪ In patients with heart failure with mildly reduced ejection fraction, LBBAP resulted in a significant increase in ejection fraction.</description><identifier>ISSN: 0160-9289</identifier><identifier>ISSN: 1932-8737</identifier><identifier>EISSN: 1932-8737</identifier><identifier>DOI: 10.1002/clc.24028</identifier><identifier>PMID: 37144691</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Cardiac Pacing, Artificial - methods ; cardiac resynchronization therapy ; Cardiac Resynchronization Therapy - adverse effects ; Cardiac Resynchronization Therapy - methods ; Case reports ; Editorials ; Ejection fraction ; Electrocardiography - methods ; Heart Conduction System ; Heart failure ; Heart Failure - diagnosis ; Heart Failure - therapy ; heart failure with mildly reduced ejection fraction ; Humans ; left bundle branch area pacing ; left ventricular ejection fraction ; Literature reviews ; Meta-analysis ; Morphology ; QRS duration ; Review ; Reviews ; Standard deviation ; Stroke Volume ; Transplants & implants ; Treatment Outcome ; Ventricular Function, Left</subject><ispartof>Clinical cardiology (Mahwah, N.J.), 2023-07, Vol.46 (7), p.713-720</ispartof><rights>2023 The Authors. published by Wiley Periodicals LLC.</rights><rights>2023 The Authors. Clinical Cardiology published by Wiley Periodicals LLC.</rights><rights>2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4448-f9bfe80da7cc40b65a0dd5c46c1e607c9b364b0fe373f93b916c64d46cb998dd3</citedby><cites>FETCH-LOGICAL-c4448-f9bfe80da7cc40b65a0dd5c46c1e607c9b364b0fe373f93b916c64d46cb998dd3</cites><orcidid>0000-0001-7799-104X ; 0000-0003-4200-3456</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352976/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352976/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37144691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Ga‐In</creatorcontrib><creatorcontrib>Kim, Tae‐Hoon</creatorcontrib><creatorcontrib>Cho, Yun‐Ho</creatorcontrib><creatorcontrib>Bae, Jae‐Seok</creatorcontrib><creatorcontrib>Ahn, Jong‐Hwa</creatorcontrib><creatorcontrib>Jang, Jeong Yoon</creatorcontrib><creatorcontrib>Park, Yong Whi</creatorcontrib><creatorcontrib>Kwak, Choong Hwan</creatorcontrib><title>Left bundle branch area pacing in mildly reduced heart failure: A systematic literature review and meta‐analysis</title><title>Clinical cardiology (Mahwah, N.J.)</title><addtitle>Clin Cardiol</addtitle><description>Cardiac resynchronization therapy (CRT) strategy for heart failure with mildly reduced ejection fraction (HFmrEF) is controversial. Left bundle branch area pacing (LBBAP) is an emerging pacing modality and an alternative option to CRT. This analysis aimed to perform a systematic review of the literature and meta‐analysis on the impact of the LBBAP strategy in HFmrEF, with left ventricular ejection fraction (LVEF) between 35% and 50%. PubMed, Embase, and Cochrane Library were searched for full‐text articles on LBBAP from inception to July 17, 2022. The outcomes of interest were QRS duration and LVEF at baseline and follow‐up in mid‐range heart failure. Data were extracted and summarized. A random‐effect model incorporating the potential heterogeneity was used to synthesize the results. Out of 1065 articles, 8 met the inclusion criteria for 211 mid‐range heart failure patients with an implant LBBAP across the 16 centers. The average implant success rate with lumenless pacing lead use was 91.3%, and 19 complications were reported among all 211 enrolled patients. During the average follow‐up of 9.1 months, the average LVEF was 39.8% at baseline and 50.5% at follow‐up (MD: 10.90%, 95% CI: 6.56−15.23, p < .01). Average QRS duration was 152.6 ms at baseline and 119.3 ms at follow‐up (MD: −34.51 ms, 95% CI: −60.00 to −9.02, p < .01). LBBAP could significantly reduce QRS duration and improve systolic function in a patient with LVEF between 35% and 50%. Application of LBBAP as a CRT strategy for HFmrEF may be a viable option.
Average left ventricular ejection fraction (LVEF) from implant to follow‐up for baseline LVEF between 35% and 50% versus LVEF <35%.
▪ Left bundle branch area pacing (LBBAP) was found to significantly shorten QRS duration and improve systolic cardiac function in patients with a LVEF of 35%−50%.
▪ In patients with heart failure with mildly reduced ejection fraction, LBBAP resulted in a significant increase in ejection fraction.</description><subject>Cardiac Pacing, Artificial - methods</subject><subject>cardiac resynchronization therapy</subject><subject>Cardiac Resynchronization Therapy - adverse effects</subject><subject>Cardiac Resynchronization Therapy - methods</subject><subject>Case reports</subject><subject>Editorials</subject><subject>Ejection fraction</subject><subject>Electrocardiography - methods</subject><subject>Heart Conduction System</subject><subject>Heart failure</subject><subject>Heart Failure - diagnosis</subject><subject>Heart Failure - therapy</subject><subject>heart failure with mildly reduced ejection fraction</subject><subject>Humans</subject><subject>left bundle branch area pacing</subject><subject>left ventricular ejection fraction</subject><subject>Literature reviews</subject><subject>Meta-analysis</subject><subject>Morphology</subject><subject>QRS duration</subject><subject>Review</subject><subject>Reviews</subject><subject>Standard deviation</subject><subject>Stroke Volume</subject><subject>Transplants & implants</subject><subject>Treatment Outcome</subject><subject>Ventricular Function, Left</subject><issn>0160-9289</issn><issn>1932-8737</issn><issn>1932-8737</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp10c1u1DAUBWALUdGhsOAFkCU2sEhrx05is6mqET-VRmIDa-vGvum4cpLBTlplxyP0GfskuEypSiVWXpxPR9c6hLzh7JgzVp7YYI9LyUr1jKy4FmWhGtE8JyvGa1boUulD8jKly0yZKsULcigaLmWt-YrEDXYTbefBBaRthMFuKUQEugPrhwvqB9r74MJCI7rZoqNbhDjRDnyYI36kZzQtacIeJm9p8BNGmHKQ-ZXHawqDoz1OcPvrBgYIS_LpFTnoICR8ff8ekR-fP31ffy02376cr882hZVSqqLTbYeKOWislaytK2DOVVbWlmPNGqtbUcuWdSga0WnRal7bWrqct1or58QROd337ua2R2dxmCIEs4u-h7iYEbz5Nxn81lyMV4YzUZW6qXPD-_uGOP6cMU2m98liCDDgOCdTKs40F7qsMn33hF6Oc8w_vlNCVZpVSmf1Ya9sHFOK2D1cw5m5m9LkKc2fKbN9-_j8B_l3uwxO9uDaB1z-32TWm_W-8jcJ9as8</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Yu, Ga‐In</creator><creator>Kim, Tae‐Hoon</creator><creator>Cho, Yun‐Ho</creator><creator>Bae, Jae‐Seok</creator><creator>Ahn, Jong‐Hwa</creator><creator>Jang, Jeong Yoon</creator><creator>Park, Yong Whi</creator><creator>Kwak, Choong Hwan</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7799-104X</orcidid><orcidid>https://orcid.org/0000-0003-4200-3456</orcidid></search><sort><creationdate>202307</creationdate><title>Left bundle branch area pacing in mildly reduced heart failure: A systematic literature review and meta‐analysis</title><author>Yu, Ga‐In ; 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Left bundle branch area pacing (LBBAP) is an emerging pacing modality and an alternative option to CRT. This analysis aimed to perform a systematic review of the literature and meta‐analysis on the impact of the LBBAP strategy in HFmrEF, with left ventricular ejection fraction (LVEF) between 35% and 50%. PubMed, Embase, and Cochrane Library were searched for full‐text articles on LBBAP from inception to July 17, 2022. The outcomes of interest were QRS duration and LVEF at baseline and follow‐up in mid‐range heart failure. Data were extracted and summarized. A random‐effect model incorporating the potential heterogeneity was used to synthesize the results. Out of 1065 articles, 8 met the inclusion criteria for 211 mid‐range heart failure patients with an implant LBBAP across the 16 centers. The average implant success rate with lumenless pacing lead use was 91.3%, and 19 complications were reported among all 211 enrolled patients. During the average follow‐up of 9.1 months, the average LVEF was 39.8% at baseline and 50.5% at follow‐up (MD: 10.90%, 95% CI: 6.56−15.23, p < .01). Average QRS duration was 152.6 ms at baseline and 119.3 ms at follow‐up (MD: −34.51 ms, 95% CI: −60.00 to −9.02, p < .01). LBBAP could significantly reduce QRS duration and improve systolic function in a patient with LVEF between 35% and 50%. Application of LBBAP as a CRT strategy for HFmrEF may be a viable option.
Average left ventricular ejection fraction (LVEF) from implant to follow‐up for baseline LVEF between 35% and 50% versus LVEF <35%.
▪ Left bundle branch area pacing (LBBAP) was found to significantly shorten QRS duration and improve systolic cardiac function in patients with a LVEF of 35%−50%.
▪ In patients with heart failure with mildly reduced ejection fraction, LBBAP resulted in a significant increase in ejection fraction.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>37144691</pmid><doi>10.1002/clc.24028</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7799-104X</orcidid><orcidid>https://orcid.org/0000-0003-4200-3456</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Wiley Online Library Open Access; DOAJ Directory of Open Access Journals; PubMed Central; EZB Electronic Journals Library |
| subjects | Cardiac Pacing, Artificial - methods cardiac resynchronization therapy Cardiac Resynchronization Therapy - adverse effects Cardiac Resynchronization Therapy - methods Case reports Editorials Ejection fraction Electrocardiography - methods Heart Conduction System Heart failure Heart Failure - diagnosis Heart Failure - therapy heart failure with mildly reduced ejection fraction Humans left bundle branch area pacing left ventricular ejection fraction Literature reviews Meta-analysis Morphology QRS duration Review Reviews Standard deviation Stroke Volume Transplants & implants Treatment Outcome Ventricular Function, Left |
| title | Left bundle branch area pacing in mildly reduced heart failure: A systematic literature review and meta‐analysis |
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